Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets
Background/Purpose: Hypothermia (HT) remains a significant stress to the newborn and has been implicated in the pathogenesis of necrotizing enterocolitis (NEC). The authors assessed the effect of transient HT (32°C) on regional organ blood flow in anesthetized piglets at age 7 to 10 days preterm (PR...
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| Veröffentlicht in: | Journal of pediatric surgery 1999, Vol.34 (1), p.193-198 |
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| container_title | Journal of pediatric surgery |
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| creator | Powell, Randall W Dyess, Donna Lynn Collins, Jimmie N Roberts, W.Scott Tacchi, Ernest J Swafford, Albert N Ferrara, John J Ardell, Jeffrey L |
| description | Background/Purpose:
Hypothermia (HT) remains a significant stress to the newborn and has been implicated in the pathogenesis of necrotizing enterocolitis (NEC). The authors assessed the effect of transient HT (32°C) on regional organ blood flow in anesthetized piglets at age 7 to 10 days preterm (PREM), 1 to 2 days (NB), and 1 to 2 weeks (NEO).
Methods:
Radiolabeled microspheres were used to determine organ blood flows (mL/min/g) at baseline, 15, and 60 minutes after HT and 60 minutes after rewarming to baseline core temperature.
Results:
Heart rate and cardiac output decreased significantly in all groups. Cardiac flow decreased significantly in the NEO group, and central nervous system (CNS) flow decreased significantly in the NB and NEO groups. Both returned to baseline levels after rewarming. The PREM group experienced decreased cardiac, CNS, and intestinal blood flows but not to significant levels. NB and NEO intestinal blood flow showed significant decreases, which remained so after rewarming (a response not seen in hypoxia or hypovolemia). Cardiac output did not return to baseline levels in any group.
Conclusions:
HT causes derangements in organ blood flows that differ from other deleterious stimuli such as hypoxia and hypovolemia. The prolonged intestinal ischemia supports HT as a factor in the development of NEC. This delay may offer opportunity to intervene in an attempt to lessen ischemiareperfusion injury. |
| doi_str_mv | 10.1016/S0022-3468(99)90255-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69583471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022346899902555</els_id><sourcerecordid>69583471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-956f96062aa8463bf1dc8875f66c36e790af436ba1b39690f0a2df0326d6e2043</originalsourceid><addsrcrecordid>eNqFkF1LHTEQhkNpqUftT2jJRREF1042m-zmSkT8KAiFaullyGYnGtndrMkexX_fHM9BvetVmMwz7wwPIV8ZHDFg8sc1QFkWvJLNvlIHCkohCvGBLJjgrBDA649k8Ypske2U7gHyN7DPZIutOqyGBfn7G299GE1P2z6Ejro-PNGIaQpjQjoHevc8hfkO4-AN9SOdIg5mXkY8pCM-tSGOh9SMXS5yyJxjJn_b45x2ySdn-oRfNu8O-XN-dnN6WVz9uvh5enJV2Koq50IJ6ZQEWRrTVJK3jnW2aWrhpLRcYq3AuIrL1rCWK6nAgSk7B7yUncQSKr5D9ta5UwwPS0yzHnyy2PcmX7RMWirR8KpmGRRr0MaQUkSnp-gHE581A70yql-M6pUurZR-MapFnvu2WbBsB-zeTa0VZuD7BjDJmt5FM1qf3ria1YLXGTteY5htPHqMOlmPo8XOR7Sz7oL_zyX_ABI0kiU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69583471</pqid></control><display><type>article</type><title>Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Powell, Randall W ; Dyess, Donna Lynn ; Collins, Jimmie N ; Roberts, W.Scott ; Tacchi, Ernest J ; Swafford, Albert N ; Ferrara, John J ; Ardell, Jeffrey L</creator><creatorcontrib>Powell, Randall W ; Dyess, Donna Lynn ; Collins, Jimmie N ; Roberts, W.Scott ; Tacchi, Ernest J ; Swafford, Albert N ; Ferrara, John J ; Ardell, Jeffrey L</creatorcontrib><description>Background/Purpose:
Hypothermia (HT) remains a significant stress to the newborn and has been implicated in the pathogenesis of necrotizing enterocolitis (NEC). The authors assessed the effect of transient HT (32°C) on regional organ blood flow in anesthetized piglets at age 7 to 10 days preterm (PREM), 1 to 2 days (NB), and 1 to 2 weeks (NEO).
Methods:
Radiolabeled microspheres were used to determine organ blood flows (mL/min/g) at baseline, 15, and 60 minutes after HT and 60 minutes after rewarming to baseline core temperature.
Results:
Heart rate and cardiac output decreased significantly in all groups. Cardiac flow decreased significantly in the NEO group, and central nervous system (CNS) flow decreased significantly in the NB and NEO groups. Both returned to baseline levels after rewarming. The PREM group experienced decreased cardiac, CNS, and intestinal blood flows but not to significant levels. NB and NEO intestinal blood flow showed significant decreases, which remained so after rewarming (a response not seen in hypoxia or hypovolemia). Cardiac output did not return to baseline levels in any group.
Conclusions:
HT causes derangements in organ blood flows that differ from other deleterious stimuli such as hypoxia and hypovolemia. The prolonged intestinal ischemia supports HT as a factor in the development of NEC. This delay may offer opportunity to intervene in an attempt to lessen ischemiareperfusion injury.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/S0022-3468(99)90255-5</identifier><identifier>PMID: 10022170</identifier><identifier>CODEN: JPDSA3</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Age Factors ; Animals ; Animals, Newborn - physiology ; Biological and medical sciences ; Gastroenterology. Liver. Pancreas. Abdomen ; Hypothermia - physiopathology ; Intestinal Mucosa - blood supply ; Investigative techniques of hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Microspheres ; Miscellaneous ; Other diseases. Semiology ; Regional Blood Flow ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Swine ; Vascular Resistance</subject><ispartof>Journal of pediatric surgery, 1999, Vol.34 (1), p.193-198</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-956f96062aa8463bf1dc8875f66c36e790af436ba1b39690f0a2df0326d6e2043</citedby><cites>FETCH-LOGICAL-c442t-956f96062aa8463bf1dc8875f66c36e790af436ba1b39690f0a2df0326d6e2043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022346899902555$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,4010,4036,4037,23909,23910,25118,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1717537$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10022170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Powell, Randall W</creatorcontrib><creatorcontrib>Dyess, Donna Lynn</creatorcontrib><creatorcontrib>Collins, Jimmie N</creatorcontrib><creatorcontrib>Roberts, W.Scott</creatorcontrib><creatorcontrib>Tacchi, Ernest J</creatorcontrib><creatorcontrib>Swafford, Albert N</creatorcontrib><creatorcontrib>Ferrara, John J</creatorcontrib><creatorcontrib>Ardell, Jeffrey L</creatorcontrib><title>Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Background/Purpose:
Hypothermia (HT) remains a significant stress to the newborn and has been implicated in the pathogenesis of necrotizing enterocolitis (NEC). The authors assessed the effect of transient HT (32°C) on regional organ blood flow in anesthetized piglets at age 7 to 10 days preterm (PREM), 1 to 2 days (NB), and 1 to 2 weeks (NEO).
Methods:
Radiolabeled microspheres were used to determine organ blood flows (mL/min/g) at baseline, 15, and 60 minutes after HT and 60 minutes after rewarming to baseline core temperature.
Results:
Heart rate and cardiac output decreased significantly in all groups. Cardiac flow decreased significantly in the NEO group, and central nervous system (CNS) flow decreased significantly in the NB and NEO groups. Both returned to baseline levels after rewarming. The PREM group experienced decreased cardiac, CNS, and intestinal blood flows but not to significant levels. NB and NEO intestinal blood flow showed significant decreases, which remained so after rewarming (a response not seen in hypoxia or hypovolemia). Cardiac output did not return to baseline levels in any group.
Conclusions:
HT causes derangements in organ blood flows that differ from other deleterious stimuli such as hypoxia and hypovolemia. The prolonged intestinal ischemia supports HT as a factor in the development of NEC. This delay may offer opportunity to intervene in an attempt to lessen ischemiareperfusion injury.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Biological and medical sciences</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hypothermia - physiopathology</subject><subject>Intestinal Mucosa - blood supply</subject><subject>Investigative techniques of hemodynamics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Microspheres</subject><subject>Miscellaneous</subject><subject>Other diseases. Semiology</subject><subject>Regional Blood Flow</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Swine</subject><subject>Vascular Resistance</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHTEQhkNpqUftT2jJRREF1042m-zmSkT8KAiFaullyGYnGtndrMkexX_fHM9BvetVmMwz7wwPIV8ZHDFg8sc1QFkWvJLNvlIHCkohCvGBLJjgrBDA649k8Ypske2U7gHyN7DPZIutOqyGBfn7G299GE1P2z6Ejro-PNGIaQpjQjoHevc8hfkO4-AN9SOdIg5mXkY8pCM-tSGOh9SMXS5yyJxjJn_b45x2ySdn-oRfNu8O-XN-dnN6WVz9uvh5enJV2Koq50IJ6ZQEWRrTVJK3jnW2aWrhpLRcYq3AuIrL1rCWK6nAgSk7B7yUncQSKr5D9ta5UwwPS0yzHnyy2PcmX7RMWirR8KpmGRRr0MaQUkSnp-gHE581A70yql-M6pUurZR-MapFnvu2WbBsB-zeTa0VZuD7BjDJmt5FM1qf3ria1YLXGTteY5htPHqMOlmPo8XOR7Sz7oL_zyX_ABI0kiU</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Powell, Randall W</creator><creator>Dyess, Donna Lynn</creator><creator>Collins, Jimmie N</creator><creator>Roberts, W.Scott</creator><creator>Tacchi, Ernest J</creator><creator>Swafford, Albert N</creator><creator>Ferrara, John J</creator><creator>Ardell, Jeffrey L</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets</title><author>Powell, Randall W ; Dyess, Donna Lynn ; Collins, Jimmie N ; Roberts, W.Scott ; Tacchi, Ernest J ; Swafford, Albert N ; Ferrara, John J ; Ardell, Jeffrey L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-956f96062aa8463bf1dc8875f66c36e790af436ba1b39690f0a2df0326d6e2043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Biological and medical sciences</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hypothermia - physiopathology</topic><topic>Intestinal Mucosa - blood supply</topic><topic>Investigative techniques of hemodynamics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Microspheres</topic><topic>Miscellaneous</topic><topic>Other diseases. Semiology</topic><topic>Regional Blood Flow</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Swine</topic><topic>Vascular Resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Powell, Randall W</creatorcontrib><creatorcontrib>Dyess, Donna Lynn</creatorcontrib><creatorcontrib>Collins, Jimmie N</creatorcontrib><creatorcontrib>Roberts, W.Scott</creatorcontrib><creatorcontrib>Tacchi, Ernest J</creatorcontrib><creatorcontrib>Swafford, Albert N</creatorcontrib><creatorcontrib>Ferrara, John J</creatorcontrib><creatorcontrib>Ardell, Jeffrey L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Powell, Randall W</au><au>Dyess, Donna Lynn</au><au>Collins, Jimmie N</au><au>Roberts, W.Scott</au><au>Tacchi, Ernest J</au><au>Swafford, Albert N</au><au>Ferrara, John J</au><au>Ardell, Jeffrey L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>1999</date><risdate>1999</risdate><volume>34</volume><issue>1</issue><spage>193</spage><epage>198</epage><pages>193-198</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><coden>JPDSA3</coden><abstract>Background/Purpose:
Hypothermia (HT) remains a significant stress to the newborn and has been implicated in the pathogenesis of necrotizing enterocolitis (NEC). The authors assessed the effect of transient HT (32°C) on regional organ blood flow in anesthetized piglets at age 7 to 10 days preterm (PREM), 1 to 2 days (NB), and 1 to 2 weeks (NEO).
Methods:
Radiolabeled microspheres were used to determine organ blood flows (mL/min/g) at baseline, 15, and 60 minutes after HT and 60 minutes after rewarming to baseline core temperature.
Results:
Heart rate and cardiac output decreased significantly in all groups. Cardiac flow decreased significantly in the NEO group, and central nervous system (CNS) flow decreased significantly in the NB and NEO groups. Both returned to baseline levels after rewarming. The PREM group experienced decreased cardiac, CNS, and intestinal blood flows but not to significant levels. NB and NEO intestinal blood flow showed significant decreases, which remained so after rewarming (a response not seen in hypoxia or hypovolemia). Cardiac output did not return to baseline levels in any group.
Conclusions:
HT causes derangements in organ blood flows that differ from other deleterious stimuli such as hypoxia and hypovolemia. The prolonged intestinal ischemia supports HT as a factor in the development of NEC. This delay may offer opportunity to intervene in an attempt to lessen ischemiareperfusion injury.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>10022170</pmid><doi>10.1016/S0022-3468(99)90255-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of pediatric surgery, 1999, Vol.34 (1), p.193-198 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Factors Animals Animals, Newborn - physiology Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Hypothermia - physiopathology Intestinal Mucosa - blood supply Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) Medical sciences Microspheres Miscellaneous Other diseases. Semiology Regional Blood Flow Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Swine Vascular Resistance |
| title | Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets |
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