Increased p50 gating but intact prepulse inhibition in borderline personality disorder

The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. Gating of the P50, N100, and P200 auditory evoked potentials and prepulse inhibition of the startle response (PPI) were...

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Veröffentlicht in:The journal of neuropsychiatry and clinical neurosciences 2008, Vol.20 (3), p.348-356
Hauptverfasser: Grootens, Koen P, van Luijtelaar, Gilles, Miller, Christopher A F J, Smits, Tim, Hummelen, Jacobus W, Buitelaar, Jan K, Verkes, Robbert J
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container_start_page 348
container_title The journal of neuropsychiatry and clinical neurosciences
container_volume 20
creator Grootens, Koen P
van Luijtelaar, Gilles
Miller, Christopher A F J
Smits, Tim
Hummelen, Jacobus W
Buitelaar, Jan K
Verkes, Robbert J
description The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. Gating of the P50, N100, and P200 auditory evoked potentials and prepulse inhibition of the startle response (PPI) were measured in borderline patients and a group of healthy comparison subjects. Borderline patients did not show lower sensory gating, but showed higher P50, N100, and P200 gating than comparison subjects. This was mainly due to the increased response after the first stimulus. There were no group differences in PPI. Unlike in other major psychiatric disorders, such as schizophrenia, sensory (motor) gating is intact in borderline personality disorder. The higher early preattentive and mid-latency evoked potentials suggest a higher response tendency in borderline personality disorder, but this needs further replication.
doi_str_mv 10.1176/appi.neuropsych.20.3.348
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source MEDLINE; American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Acoustic Stimulation - methods
Adolescent
Adult
Analysis of Variance
Borderline Personality Disorder - pathology
Borderline Personality Disorder - physiopathology
Borderline Personality Disorder - psychology
Cerebral Cortex - physiopathology
Electroencephalography - methods
Evoked Potentials, Auditory - physiology
Female
Humans
Inhibition (Psychology)
Male
Reaction Time - physiology
Reflex, Startle - physiology
Sensory Gating - physiology
Young Adult
title Increased p50 gating but intact prepulse inhibition in borderline personality disorder
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