Increased p50 gating but intact prepulse inhibition in borderline personality disorder
The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. Gating of the P50, N100, and P200 auditory evoked potentials and prepulse inhibition of the startle response (PPI) were...
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Veröffentlicht in: | The journal of neuropsychiatry and clinical neurosciences 2008, Vol.20 (3), p.348-356 |
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creator | Grootens, Koen P van Luijtelaar, Gilles Miller, Christopher A F J Smits, Tim Hummelen, Jacobus W Buitelaar, Jan K Verkes, Robbert J |
description | The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. Gating of the P50, N100, and P200 auditory evoked potentials and prepulse inhibition of the startle response (PPI) were measured in borderline patients and a group of healthy comparison subjects. Borderline patients did not show lower sensory gating, but showed higher P50, N100, and P200 gating than comparison subjects. This was mainly due to the increased response after the first stimulus. There were no group differences in PPI. Unlike in other major psychiatric disorders, such as schizophrenia, sensory (motor) gating is intact in borderline personality disorder. The higher early preattentive and mid-latency evoked potentials suggest a higher response tendency in borderline personality disorder, but this needs further replication. |
doi_str_mv | 10.1176/appi.neuropsych.20.3.348 |
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Gating of the P50, N100, and P200 auditory evoked potentials and prepulse inhibition of the startle response (PPI) were measured in borderline patients and a group of healthy comparison subjects. Borderline patients did not show lower sensory gating, but showed higher P50, N100, and P200 gating than comparison subjects. This was mainly due to the increased response after the first stimulus. There were no group differences in PPI. Unlike in other major psychiatric disorders, such as schizophrenia, sensory (motor) gating is intact in borderline personality disorder. The higher early preattentive and mid-latency evoked potentials suggest a higher response tendency in borderline personality disorder, but this needs further replication.</description><identifier>EISSN: 1545-7222</identifier><identifier>DOI: 10.1176/appi.neuropsych.20.3.348</identifier><identifier>PMID: 18806239</identifier><language>eng</language><publisher>United States</publisher><subject>Acoustic Stimulation - methods ; Adolescent ; Adult ; Analysis of Variance ; Borderline Personality Disorder - pathology ; Borderline Personality Disorder - physiopathology ; Borderline Personality Disorder - psychology ; Cerebral Cortex - physiopathology ; Electroencephalography - methods ; Evoked Potentials, Auditory - physiology ; Female ; Humans ; Inhibition (Psychology) ; Male ; Reaction Time - physiology ; Reflex, Startle - physiology ; Sensory Gating - physiology ; Young Adult</subject><ispartof>The journal of neuropsychiatry and clinical neurosciences, 2008, Vol.20 (3), p.348-356</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c194t-a43cf47b67373ae76ed716fde908b61a8e95b12eef28ffd2791528dc5fe8f3533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18806239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grootens, Koen P</creatorcontrib><creatorcontrib>van Luijtelaar, Gilles</creatorcontrib><creatorcontrib>Miller, Christopher A F J</creatorcontrib><creatorcontrib>Smits, Tim</creatorcontrib><creatorcontrib>Hummelen, Jacobus W</creatorcontrib><creatorcontrib>Buitelaar, Jan K</creatorcontrib><creatorcontrib>Verkes, Robbert J</creatorcontrib><title>Increased p50 gating but intact prepulse inhibition in borderline personality disorder</title><title>The journal of neuropsychiatry and clinical neurosciences</title><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><description>The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. 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The higher early preattentive and mid-latency evoked potentials suggest a higher response tendency in borderline personality disorder, but this needs further replication.</description><subject>Acoustic Stimulation - methods</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Borderline Personality Disorder - pathology</subject><subject>Borderline Personality Disorder - physiopathology</subject><subject>Borderline Personality Disorder - psychology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Electroencephalography - methods</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Inhibition (Psychology)</subject><subject>Male</subject><subject>Reaction Time - physiology</subject><subject>Reflex, Startle - physiology</subject><subject>Sensory Gating - physiology</subject><subject>Young Adult</subject><issn>1545-7222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UDtPwzAYtJAQLYW_gDyxJfgRPzKiikelSizAGjnx59YodYztDP33VFCmu9M9hkMIU1JTquSDidHXAeY0xXwc9jUjNa95oy_QkopGVIoxtkDXOX8RQhiXzRVaUK2JZLxdos9NGBKYDBZHQfDOFB92uJ8L9qGYoeCYIM5jhpPe-94XP4UTxf2ULKTRB8ARUp6CGX05Yuvzr3GDLp05tW7PuEIfz0_v69dq-_ayWT9uq4G2TalMwwfXqF4qrrgBJcEqKp2FluheUqOhFT1lAI5p5yxTLRVM20E40I4Lzlfo_m83pul7hly6g88DjKMJMM25k63QTBN1Ct6dg3N_ANvF5A8mHbv_J_gPqn9kQA</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Grootens, Koen P</creator><creator>van Luijtelaar, Gilles</creator><creator>Miller, Christopher A F J</creator><creator>Smits, Tim</creator><creator>Hummelen, Jacobus W</creator><creator>Buitelaar, Jan K</creator><creator>Verkes, Robbert J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Increased p50 gating but intact prepulse inhibition in borderline personality disorder</title><author>Grootens, Koen P ; van Luijtelaar, Gilles ; Miller, Christopher A F J ; Smits, Tim ; Hummelen, Jacobus W ; Buitelaar, Jan K ; Verkes, Robbert J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c194t-a43cf47b67373ae76ed716fde908b61a8e95b12eef28ffd2791528dc5fe8f3533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Borderline Personality Disorder - pathology</topic><topic>Borderline Personality Disorder - physiopathology</topic><topic>Borderline Personality Disorder - psychology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Electroencephalography - methods</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Inhibition (Psychology)</topic><topic>Male</topic><topic>Reaction Time - physiology</topic><topic>Reflex, Startle - physiology</topic><topic>Sensory Gating - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grootens, Koen P</creatorcontrib><creatorcontrib>van Luijtelaar, Gilles</creatorcontrib><creatorcontrib>Miller, Christopher A F J</creatorcontrib><creatorcontrib>Smits, Tim</creatorcontrib><creatorcontrib>Hummelen, Jacobus W</creatorcontrib><creatorcontrib>Buitelaar, Jan K</creatorcontrib><creatorcontrib>Verkes, Robbert J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grootens, Koen P</au><au>van Luijtelaar, Gilles</au><au>Miller, Christopher A F J</au><au>Smits, Tim</au><au>Hummelen, Jacobus W</au><au>Buitelaar, Jan K</au><au>Verkes, Robbert J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased p50 gating but intact prepulse inhibition in borderline personality disorder</atitle><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><date>2008</date><risdate>2008</risdate><volume>20</volume><issue>3</issue><spage>348</spage><epage>356</epage><pages>348-356</pages><eissn>1545-7222</eissn><abstract>The authors explore sensory gating deficits in borderline personality disorder patients, such as those described in schizophrenia, in patients with borderline personality disorder. 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subjects | Acoustic Stimulation - methods Adolescent Adult Analysis of Variance Borderline Personality Disorder - pathology Borderline Personality Disorder - physiopathology Borderline Personality Disorder - psychology Cerebral Cortex - physiopathology Electroencephalography - methods Evoked Potentials, Auditory - physiology Female Humans Inhibition (Psychology) Male Reaction Time - physiology Reflex, Startle - physiology Sensory Gating - physiology Young Adult |
title | Increased p50 gating but intact prepulse inhibition in borderline personality disorder |
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