Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients
The serotonergic system has repeatedly been discussed to be involved in the pathophysiology of fibromyalgia (FM), which is a syndrome of widespread pain and sleep disturbance. Elevated levels of substance P (SP), a mediator of nociception, have been described in FM. In this study the possible relati...
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| Veröffentlicht in: | Neuroscience letters 1999-01, Vol.259 (3), p.196-198 |
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| creator | Schwarz, Marcus J Späth, Michael Müller-Bardorff, Hanns Pongratz, Dieter E Bondy, Brigitta Ackenheil, Manfred |
| description | The serotonergic system has repeatedly been discussed to be involved in the pathophysiology of fibromyalgia (FM), which is a syndrome of widespread pain and sleep disturbance. Elevated levels of substance P (SP), a mediator of nociception, have been described in FM. In this study the possible relationship between SP and serotonin (5-HT) together with its precursor tryptophan (TRP) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) was evaluated in 51 serum samples of fibromyalgia patients. These parameters were compared with clinical data such as pain intensity or sleep quality. A strong negative correlation between SP and 5-HIAA (
P=.000) as well as between SP and TRP (
P=.009) could be demonstrated. High serum concentrations of 5-HIAA and TRP showed a significant relation to low pain scores (5-HIAA:
P=.030; TRP:
P=.014). Moreover, 5-HIAA was strongly related to good quality of sleep (
P=.000), while SP was related to sleep disturbance (
P=.005). These data are valid to support the hypothesis of a systemic involvement of 5-HT and SP in fibromyalgia. |
| doi_str_mv | 10.1016/S0304-3940(98)00937-9 |
| format | Article |
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P=.000) as well as between SP and TRP (
P=.009) could be demonstrated. High serum concentrations of 5-HIAA and TRP showed a significant relation to low pain scores (5-HIAA:
P=.030; TRP:
P=.014). Moreover, 5-HIAA was strongly related to good quality of sleep (
P=.000), while SP was related to sleep disturbance (
P=.005). These data are valid to support the hypothesis of a systemic involvement of 5-HT and SP in fibromyalgia.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(98)00937-9</identifier><identifier>PMID: 10025591</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>5-Hydroxyindoleacetic acid ; 5-Hydroxytryptamine ; Adult ; Biological and medical sciences ; Biomarkers - blood ; Diseases of striated muscles. Neuromuscular diseases ; Female ; Fibromyalgia ; Fibromyalgia - blood ; Fibromyalgia - etiology ; Humans ; Hydroxyindoleacetic Acid - blood ; Male ; Medical sciences ; Middle Aged ; Neurology ; Pain ; Pain - blood ; Serotonin ; Sleep ; Substance P ; Substance P - blood ; Tryptophan ; Tryptophan - blood</subject><ispartof>Neuroscience letters, 1999-01, Vol.259 (3), p.196-198</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-c265f4478ec16b6fe7b45c91cd0d33dbff2af1be68e677aa8dfd8f03aa49ad293</citedby><cites>FETCH-LOGICAL-c446t-c265f4478ec16b6fe7b45c91cd0d33dbff2af1be68e677aa8dfd8f03aa49ad293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(98)00937-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1655875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10025591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwarz, Marcus J</creatorcontrib><creatorcontrib>Späth, Michael</creatorcontrib><creatorcontrib>Müller-Bardorff, Hanns</creatorcontrib><creatorcontrib>Pongratz, Dieter E</creatorcontrib><creatorcontrib>Bondy, Brigitta</creatorcontrib><creatorcontrib>Ackenheil, Manfred</creatorcontrib><title>Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The serotonergic system has repeatedly been discussed to be involved in the pathophysiology of fibromyalgia (FM), which is a syndrome of widespread pain and sleep disturbance. Elevated levels of substance P (SP), a mediator of nociception, have been described in FM. In this study the possible relationship between SP and serotonin (5-HT) together with its precursor tryptophan (TRP) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) was evaluated in 51 serum samples of fibromyalgia patients. These parameters were compared with clinical data such as pain intensity or sleep quality. A strong negative correlation between SP and 5-HIAA (
P=.000) as well as between SP and TRP (
P=.009) could be demonstrated. High serum concentrations of 5-HIAA and TRP showed a significant relation to low pain scores (5-HIAA:
P=.030; TRP:
P=.014). Moreover, 5-HIAA was strongly related to good quality of sleep (
P=.000), while SP was related to sleep disturbance (
P=.005). These data are valid to support the hypothesis of a systemic involvement of 5-HT and SP in fibromyalgia.</description><subject>5-Hydroxyindoleacetic acid</subject><subject>5-Hydroxytryptamine</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Female</subject><subject>Fibromyalgia</subject><subject>Fibromyalgia - blood</subject><subject>Fibromyalgia - etiology</subject><subject>Humans</subject><subject>Hydroxyindoleacetic Acid - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Pain</subject><subject>Pain - blood</subject><subject>Serotonin</subject><subject>Sleep</subject><subject>Substance P</subject><subject>Substance P - blood</subject><subject>Tryptophan</subject><subject>Tryptophan - blood</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMozp3Rn6BkIaJgNWnzuRIZxg8YUPxYhzQ58Ubapiap2H9v79yLupvV2TznPYfnRegRJS8poeLVF9IR1nSakWdaPSdEd7LRd9COKtk2Usv2Ltr9Rc7QeSk_CCGccnYfnVFCWs413aH4GQZbY5rKPs44BVyWvlQ7OcCfXmDe7Fef0-81Tj4NgK2DGt02osd28rjmda5p3tsJxwkXyMt4yAixz2lc7fA9Wjxv8TDV8gDdC3Yo8PA0L9C3t1dfL9831x_ffbh8c904xkRtXCt4YEwqcFT0IoDsGXeaOk981_k-hNYG2oNQIKS0VvngVSCdtUxb3-ruAj095s45_VygVDPG4mAY7ARpKUZormgn2a0gla3iitEN5EfQ5VRKhmDmHEebV0OJOZRhbsowB9NGK3NThjl88vh0YOlH8P9tHe1vwJMTYIuzQ8ib91j-cYJzJfmGvT5isGn7FSGb4jalDnzM4KrxKd7yyR8Ucqgm</recordid><startdate>19990115</startdate><enddate>19990115</enddate><creator>Schwarz, Marcus J</creator><creator>Späth, Michael</creator><creator>Müller-Bardorff, Hanns</creator><creator>Pongratz, Dieter E</creator><creator>Bondy, Brigitta</creator><creator>Ackenheil, Manfred</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19990115</creationdate><title>Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients</title><author>Schwarz, Marcus J ; Späth, Michael ; Müller-Bardorff, Hanns ; Pongratz, Dieter E ; Bondy, Brigitta ; Ackenheil, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-c265f4478ec16b6fe7b45c91cd0d33dbff2af1be68e677aa8dfd8f03aa49ad293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>5-Hydroxyindoleacetic acid</topic><topic>5-Hydroxytryptamine</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Female</topic><topic>Fibromyalgia</topic><topic>Fibromyalgia - blood</topic><topic>Fibromyalgia - etiology</topic><topic>Humans</topic><topic>Hydroxyindoleacetic Acid - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Pain</topic><topic>Pain - blood</topic><topic>Serotonin</topic><topic>Sleep</topic><topic>Substance P</topic><topic>Substance P - blood</topic><topic>Tryptophan</topic><topic>Tryptophan - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwarz, Marcus J</creatorcontrib><creatorcontrib>Späth, Michael</creatorcontrib><creatorcontrib>Müller-Bardorff, Hanns</creatorcontrib><creatorcontrib>Pongratz, Dieter E</creatorcontrib><creatorcontrib>Bondy, Brigitta</creatorcontrib><creatorcontrib>Ackenheil, Manfred</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwarz, Marcus J</au><au>Späth, Michael</au><au>Müller-Bardorff, Hanns</au><au>Pongratz, Dieter E</au><au>Bondy, Brigitta</au><au>Ackenheil, Manfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1999-01-15</date><risdate>1999</risdate><volume>259</volume><issue>3</issue><spage>196</spage><epage>198</epage><pages>196-198</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The serotonergic system has repeatedly been discussed to be involved in the pathophysiology of fibromyalgia (FM), which is a syndrome of widespread pain and sleep disturbance. Elevated levels of substance P (SP), a mediator of nociception, have been described in FM. In this study the possible relationship between SP and serotonin (5-HT) together with its precursor tryptophan (TRP) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) was evaluated in 51 serum samples of fibromyalgia patients. These parameters were compared with clinical data such as pain intensity or sleep quality. A strong negative correlation between SP and 5-HIAA (
P=.000) as well as between SP and TRP (
P=.009) could be demonstrated. High serum concentrations of 5-HIAA and TRP showed a significant relation to low pain scores (5-HIAA:
P=.030; TRP:
P=.014). Moreover, 5-HIAA was strongly related to good quality of sleep (
P=.000), while SP was related to sleep disturbance (
P=.005). These data are valid to support the hypothesis of a systemic involvement of 5-HT and SP in fibromyalgia.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10025591</pmid><doi>10.1016/S0304-3940(98)00937-9</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1999-01, Vol.259 (3), p.196-198 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| subjects | 5-Hydroxyindoleacetic acid 5-Hydroxytryptamine Adult Biological and medical sciences Biomarkers - blood Diseases of striated muscles. Neuromuscular diseases Female Fibromyalgia Fibromyalgia - blood Fibromyalgia - etiology Humans Hydroxyindoleacetic Acid - blood Male Medical sciences Middle Aged Neurology Pain Pain - blood Serotonin Sleep Substance P Substance P - blood Tryptophan Tryptophan - blood |
| title | Relationship of substance P, 5-hydroxyindole acetic acid and tryptophan in serum of fibromyalgia patients |
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