Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

Deubiquitinating enzymes (DUBs) remove ubiquitin from conjugated substrates to regulate various cellular processes. The Zn 2+ -dependent DUBs AMSH and AMSH-LP regulate receptor trafficking by specifically cleaving Lys 63-linked polyubiquitin chains from internalized receptors. Here we report the cry...

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Veröffentlicht in:	Nature (London) 2008-09, Vol.455 (7211), p.358-362
Hauptverfasser:	Sato, Yusuke, Yoshikawa, Azusa, Yamagata, Atsushi, Mimura, Hisatoshi, Yamashita, Masami, Ookata, Kayoko, Nureki, Osamu, Iwai, Kazuhiro, Komada, Masayuki, Fukai, Shuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Catalysis Conserved Sequence Crystalline structure Crystallography, X-Ray Data collection DNA repair E coli Endopeptidases - chemistry Endopeptidases - metabolism Endosomal Sorting Complexes Required for Transport Escherichia coli Fundamental and applied biological sciences. Psychology Human genome Humanities and Social Sciences Humans Kinetics Lysine - metabolism Mice Models, Molecular Molecular biophysics multidisciplinary Physiological aspects Polyubiquitin - chemistry Polyubiquitin - genetics Polyubiquitin - metabolism Protein Structure, Tertiary Proteins Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary) Structure in molecular biology Structure-Activity Relationship Substrate Specificity Ubiquitin Ubiquitin Thiolesterase - chemistry Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ubiquitin-proteasome system
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