Topology of the Stable Serpin-Protease Complexes Revealed by an Autoantibody That Fails to React with the Monomeric Conformers of Antithrombin

Solving the structure of the stable complex between a serine protease inhibitor (serpin) and its target has been a long standing goal. We describe herein the characterization of a monoclonal antibody that selectively recognizes antithrombin in complex with either thrombin, factor Xa, or a synthetic...

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Veröffentlicht in:	The Journal of biological chemistry 1999-02, Vol.274 (8), p.4586-4593
Hauptverfasser:	Picard, V, Marque, P E, Paolucci, F, Aiach, M, Le Bonniec, B F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antithrombins - chemistry Antithrombins - immunology Antithrombins - metabolism Autoantibodies - immunology Humans Mice Mice, Inbred BALB C Molecular Conformation Molecular Sequence Data Serine Endopeptidases - chemistry Serine Endopeptidases - metabolism
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