Urokinase Activates the Jak/Stat Signal Transduction Pathway in Human Vascular Endothelial Cells

Endothelial cells demonstrate high urokinase expression and upregulation of urokinase receptors in response to vascular injury. Urokinase receptor binding facilitates endothelial cell migration into an arterial wound; however, the signaling cascade induced by the urokinase receptor in this cell type...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1999-02, Vol.19 (2), p.290-297
Hauptverfasser:	Dumler, Inna, Kopmann, Angela, Weis, Angelika, Mayboroda, Oleg A, Wagner, Kai, Gulba, Dietrich C, Haller, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological Transport - drug effects Blood vessels and receptors Cell Nucleus - metabolism Cells, Cultured DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Humans Interferons - pharmacology Janus Kinase 1 Phosphorylation Plasminogen Activators - pharmacology Protein-Tyrosine Kinases - physiology Proteins - physiology Response Elements - drug effects Response Elements - physiology Signal Transduction - physiology STAT1 Transcription Factor Trans-Activators - metabolism Trans-Activators - physiology TYK2 Kinase Tyrosine - metabolism Urokinase-Type Plasminogen Activator - pharmacology Vertebrates: cardiovascular system
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