Toward a framework linkage map of the canine genome
Selective breeding to maintain specific physical and behavioral traits has made the modern dog one of the most physically diverse species on earth. One unfortunate consequence of the common breeding practices used to develop lines of dogs with the desired traits is amplification and propagation of g...
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| Veröffentlicht in: | Journal of Heredity 1999-01, Vol.90 (1), p.7-14 |
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| container_title | Journal of Heredity |
| container_volume | 90 |
| creator | Langston, A.A Mellersh, C.S Wiegand, N.A Acland, G.M Ray, K Aguirre, G.D Ostrander, E.A |
| description | Selective breeding to maintain specific physical and behavioral traits has made the modern dog one of the most physically diverse species on earth. One unfortunate consequence of the common breeding practices used to develop lines of dogs with the desired traits is amplification and propagation of genetic diseases within distinct breeds. To map disease loci we have constructed a first-generation framework map of the canine genome. We developed large numbers of highly polymorphic markers, constructed a panel of canine-rodent hybrid cell lines, and assigned those markers to chromosome groups using the hybrid cell lines. Finally, we determined the order and spacing of markers on individual canine chromosomes by linkage analysis using a reference panel of 17 outbred pedigrees. This article describes approaches and strategies to accomplish these goals. |
| doi_str_mv | 10.1093/jhered/90.1.7 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-1503 |
| ispartof | Journal of Heredity, 1999-01, Vol.90 (1), p.7-14 |
| issn | 0022-1503 1471-8505 1465-7333 1471-8505 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69579441 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Breeding Breeding of animals Chromosome Mapping - veterinary Dogs Dogs - genetics Genetic Linkage Genetic Markers Genetics Lod Score Pedigree |
| title | Toward a framework linkage map of the canine genome |
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