EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: A double-blind, placebo-controlled study
Background: A granulating surface is important for skin grafting and healing of leg ulcers. Mechanical debridement to remove necrotic tissue often must be stopped before completion because of pain. Objective: Our purpose was to assess the effect of EMLA cream on the number of debridements required t...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1999-02, Vol.40 (2), p.208-213 |
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| container_title | Journal of the American Academy of Dermatology |
| container_volume | 40 |
| creator | Lok, Catherine Paul, Carle Amblard, Pierre Bessis, Didier Debure, Clélia Faivre, Brigitte Guillot, Bernard Ortonne, Jean Paul Huledal, Gunilla Kalis, Bernard |
| description | Background: A granulating surface is important for skin grafting and healing of leg ulcers. Mechanical debridement to remove necrotic tissue often must be stopped before completion because of pain.
Objective: Our purpose was to assess the effect of EMLA cream on the number of debridements required to obtain a clean ulcer and on pain during debridement and to determine its safety after repeated doses.
Methods: In this randomized double-blind, placebo-controlled study, 69 patients with venous leg ulcers received cream before debridement until a clean ulcer was obtained (or a maximum of 15 debridements).
Results: EMLA decreased the median number of debridements required for a clean ulcer (EMLA 11.5, placebo >15;
P = .019) and decreased pain by 50% (
P = .003). Plasma levels of lidocaine, prilocaine, and their main metabolites were low without any apparent accumulation.
Conclusion: EMLA produces effective pain relief for the debridement of leg ulcers and shortens the time to a clean ulcer. (J Am Acad Dermatol 1999;40:208-13.) |
| doi_str_mv | 10.1016/S0190-9622(99)70190-8 |
| format | Article |
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Objective: Our purpose was to assess the effect of EMLA cream on the number of debridements required to obtain a clean ulcer and on pain during debridement and to determine its safety after repeated doses.
Methods: In this randomized double-blind, placebo-controlled study, 69 patients with venous leg ulcers received cream before debridement until a clean ulcer was obtained (or a maximum of 15 debridements).
Results: EMLA decreased the median number of debridements required for a clean ulcer (EMLA 11.5, placebo >15;
P = .019) and decreased pain by 50% (
P = .003). Plasma levels of lidocaine, prilocaine, and their main metabolites were low without any apparent accumulation.
Conclusion: EMLA produces effective pain relief for the debridement of leg ulcers and shortens the time to a clean ulcer. (J Am Acad Dermatol 1999;40:208-13.)</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(99)70190-8</identifier><identifier>PMID: 10025747</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Administration, Cutaneous ; Aged ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Local - administration & dosage ; Anesthetics, Local - blood ; Biological and medical sciences ; Debridement - methods ; Double-Blind Method ; Female ; Humans ; Lidocaine - administration & dosage ; Lidocaine - blood ; Lidocaine, Prilocaine Drug Combination ; Local anesthesia. Pain (treatment) ; Male ; Medical sciences ; Ointments ; Pain - prevention & control ; Prilocaine - administration & dosage ; Prilocaine - blood ; Time Factors ; Treatment Outcome ; Varicose Ulcer - surgery ; Wound Healing</subject><ispartof>Journal of the American Academy of Dermatology, 1999-02, Vol.40 (2), p.208-213</ispartof><rights>1999 American Academy of Dermatology, Inc</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-5928e506b19519efc48c431c90310260a5340b52e53793a5b5694d17c386735b3</citedby><cites>FETCH-LOGICAL-c415t-5928e506b19519efc48c431c90310260a5340b52e53793a5b5694d17c386735b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0190-9622(99)70190-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1688966$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10025747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lok, Catherine</creatorcontrib><creatorcontrib>Paul, Carle</creatorcontrib><creatorcontrib>Amblard, Pierre</creatorcontrib><creatorcontrib>Bessis, Didier</creatorcontrib><creatorcontrib>Debure, Clélia</creatorcontrib><creatorcontrib>Faivre, Brigitte</creatorcontrib><creatorcontrib>Guillot, Bernard</creatorcontrib><creatorcontrib>Ortonne, Jean Paul</creatorcontrib><creatorcontrib>Huledal, Gunilla</creatorcontrib><creatorcontrib>Kalis, Bernard</creatorcontrib><title>EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: A double-blind, placebo-controlled study</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background: A granulating surface is important for skin grafting and healing of leg ulcers. Mechanical debridement to remove necrotic tissue often must be stopped before completion because of pain.
Objective: Our purpose was to assess the effect of EMLA cream on the number of debridements required to obtain a clean ulcer and on pain during debridement and to determine its safety after repeated doses.
Methods: In this randomized double-blind, placebo-controlled study, 69 patients with venous leg ulcers received cream before debridement until a clean ulcer was obtained (or a maximum of 15 debridements).
Results: EMLA decreased the median number of debridements required for a clean ulcer (EMLA 11.5, placebo >15;
P = .019) and decreased pain by 50% (
P = .003). Plasma levels of lidocaine, prilocaine, and their main metabolites were low without any apparent accumulation.
Conclusion: EMLA produces effective pain relief for the debridement of leg ulcers and shortens the time to a clean ulcer. (J Am Acad Dermatol 1999;40:208-13.)</description><subject>Administration, Cutaneous</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics, Local - blood</subject><subject>Biological and medical sciences</subject><subject>Debridement - methods</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Lidocaine - administration & dosage</subject><subject>Lidocaine - blood</subject><subject>Lidocaine, Prilocaine Drug Combination</subject><subject>Local anesthesia. Pain (treatment)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ointments</subject><subject>Pain - prevention & control</subject><subject>Prilocaine - administration & dosage</subject><subject>Prilocaine - blood</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Varicose Ulcer - surgery</subject><subject>Wound Healing</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9lr9CUoWUhQcTWYmycRNuZRqC1dcqOuQjzM2kpmMSabQn-C_Nr33ou5cHHICz_l6X4SeU_KWEsrffSFUkkbytn0l5Wux_w0P0IYSKRouBvEQbf4gJ-hJzj8IIbLvxGN0QglpmejFBv26_LTbYptAT1hnrHGJi7c6YD1DLjdQvMVjTLimOMECuoDDE9gbPe8xByZ5BxPMBccR38Ic14wDfMdrsJDye7zFLq4mQGOCn90bvARtwcTGxrmkGELtl8vq7p6iR6MOGZ4d31P07cPl14urZvf54_XFdtfYnrLSMNkOwAg3VDIqYbT9YPuOWkk6SlpONOt6YlgLrBOy08wwLntHhe0GLjpmulN0dui7pPhzrUeqyWcLIdSL6-6KSyZqsAqyA2hTzDnBqJbkJ53uFCXq3gO190DdC6ykVHsP1FDrXhwHrGYC90_VQfQKvDwCOlcNx6Rn6_Nfjg-D5Lxi5wcMqhq3HpLK1sNswfkEtigX_X82-Q3wraLK</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Lok, Catherine</creator><creator>Paul, Carle</creator><creator>Amblard, Pierre</creator><creator>Bessis, Didier</creator><creator>Debure, Clélia</creator><creator>Faivre, Brigitte</creator><creator>Guillot, Bernard</creator><creator>Ortonne, Jean Paul</creator><creator>Huledal, Gunilla</creator><creator>Kalis, Bernard</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: A double-blind, placebo-controlled study</title><author>Lok, Catherine ; Paul, Carle ; Amblard, Pierre ; Bessis, Didier ; Debure, Clélia ; Faivre, Brigitte ; Guillot, Bernard ; Ortonne, Jean Paul ; Huledal, Gunilla ; Kalis, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-5928e506b19519efc48c431c90310260a5340b52e53793a5b5694d17c386735b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Cutaneous</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics, Local - blood</topic><topic>Biological and medical sciences</topic><topic>Debridement - methods</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Lidocaine - administration & dosage</topic><topic>Lidocaine - blood</topic><topic>Lidocaine, Prilocaine Drug Combination</topic><topic>Local anesthesia. Pain (treatment)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ointments</topic><topic>Pain - prevention & control</topic><topic>Prilocaine - administration & dosage</topic><topic>Prilocaine - blood</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Varicose Ulcer - surgery</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lok, Catherine</creatorcontrib><creatorcontrib>Paul, Carle</creatorcontrib><creatorcontrib>Amblard, Pierre</creatorcontrib><creatorcontrib>Bessis, Didier</creatorcontrib><creatorcontrib>Debure, Clélia</creatorcontrib><creatorcontrib>Faivre, Brigitte</creatorcontrib><creatorcontrib>Guillot, Bernard</creatorcontrib><creatorcontrib>Ortonne, Jean Paul</creatorcontrib><creatorcontrib>Huledal, Gunilla</creatorcontrib><creatorcontrib>Kalis, Bernard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lok, Catherine</au><au>Paul, Carle</au><au>Amblard, Pierre</au><au>Bessis, Didier</au><au>Debure, Clélia</au><au>Faivre, Brigitte</au><au>Guillot, Bernard</au><au>Ortonne, Jean Paul</au><au>Huledal, Gunilla</au><au>Kalis, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: A double-blind, placebo-controlled study</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>40</volume><issue>2</issue><spage>208</spage><epage>213</epage><pages>208-213</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Background: A granulating surface is important for skin grafting and healing of leg ulcers. Mechanical debridement to remove necrotic tissue often must be stopped before completion because of pain.
Objective: Our purpose was to assess the effect of EMLA cream on the number of debridements required to obtain a clean ulcer and on pain during debridement and to determine its safety after repeated doses.
Methods: In this randomized double-blind, placebo-controlled study, 69 patients with venous leg ulcers received cream before debridement until a clean ulcer was obtained (or a maximum of 15 debridements).
Results: EMLA decreased the median number of debridements required for a clean ulcer (EMLA 11.5, placebo >15;
P = .019) and decreased pain by 50% (
P = .003). Plasma levels of lidocaine, prilocaine, and their main metabolites were low without any apparent accumulation.
Conclusion: EMLA produces effective pain relief for the debridement of leg ulcers and shortens the time to a clean ulcer. (J Am Acad Dermatol 1999;40:208-13.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>10025747</pmid><doi>10.1016/S0190-9622(99)70190-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Dermatology, 1999-02, Vol.40 (2), p.208-213 |
| issn | 0190-9622 1097-6787 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Cutaneous Aged Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Local - administration & dosage Anesthetics, Local - blood Biological and medical sciences Debridement - methods Double-Blind Method Female Humans Lidocaine - administration & dosage Lidocaine - blood Lidocaine, Prilocaine Drug Combination Local anesthesia. Pain (treatment) Male Medical sciences Ointments Pain - prevention & control Prilocaine - administration & dosage Prilocaine - blood Time Factors Treatment Outcome Varicose Ulcer - surgery Wound Healing |
| title | EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: A double-blind, placebo-controlled study |
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