Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma
The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 an...
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| Veröffentlicht in: | Oncogene 1999-01, Vol.18 (4), p.1007-1014 |
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| creator | TOMIZAWA, Y KOHNO, T YOKOTA, J FUJITA, T KIYAMA, M SAITO, R NOGUCHI, M MATSUNO, Y HIROHASHI, S YAMAGUCHI, N NAKAJIMA, T |
| description | The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P |
| doi_str_mv | 10.1038/sj.onc.1202384 |
| format | Article |
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Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1202384</identifier><identifier>PMID: 10023676</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Alleles ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Chromosomes, Human, Pair 17 - genetics ; DNA Mutational Analysis ; DNA, Neoplasm - genetics ; Exons - genetics ; Fundamental and applied biological sciences. Psychology ; Genes, p53 - genetics ; Genetic Markers ; Humans ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Medical sciences ; Molecular and cellular biology ; Neoplasm Staging ; Pneumology ; Point Mutation ; Prognosis ; Tumor Suppressor Protein p53 - metabolism ; Tumors of the respiratory system and mediastinum</subject><ispartof>Oncogene, 1999-01, Vol.18 (4), p.1007-1014</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-1e33e0ee75b324ea40b764d0d30724e93298e2d6e05dd2ed947fa484bd59362d3</citedby><cites>FETCH-LOGICAL-c351t-1e33e0ee75b324ea40b764d0d30724e93298e2d6e05dd2ed947fa484bd59362d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1707548$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10023676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOMIZAWA, Y</creatorcontrib><creatorcontrib>KOHNO, T</creatorcontrib><creatorcontrib>YOKOTA, J</creatorcontrib><creatorcontrib>FUJITA, T</creatorcontrib><creatorcontrib>KIYAMA, M</creatorcontrib><creatorcontrib>SAITO, R</creatorcontrib><creatorcontrib>NOGUCHI, M</creatorcontrib><creatorcontrib>MATSUNO, Y</creatorcontrib><creatorcontrib>HIROHASHI, S</creatorcontrib><creatorcontrib>YAMAGUCHI, N</creatorcontrib><creatorcontrib>NAKAJIMA, T</creatorcontrib><title>Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). 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Action of oncogenes and antioncogenes</topic><topic>Chromosomes, Human, Pair 17 - genetics</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Neoplasm - genetics</topic><topic>Exons - genetics</topic><topic>Fundamental and applied biological sciences. 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Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>10023676</pmid><doi>10.1038/sj.onc.1202384</doi><tpages>8</tpages></addata></record> |
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| subjects | Alleles Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosomes, Human, Pair 17 - genetics DNA Mutational Analysis DNA, Neoplasm - genetics Exons - genetics Fundamental and applied biological sciences. Psychology Genes, p53 - genetics Genetic Markers Humans Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Medical sciences Molecular and cellular biology Neoplasm Staging Pneumology Point Mutation Prognosis Tumor Suppressor Protein p53 - metabolism Tumors of the respiratory system and mediastinum |
| title | Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma |
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