NFATc1 Regulates PD-1 Expression upon T Cell Activation

PD-1 is a transmembrane protein involved in the regulation of immunological tolerance. Multiple studies have reported an association between high levels of PD-1 expressed on T cell surfaces and exhaustion in lymphocyte populations when challenged by chronic viral infections, such as HIV. By using mo...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-10, Vol.181 (7), p.4832-4839
Hauptverfasser:	Oestreich, Kenneth J, Yoon, Hyesuk, Ahmed, Rafi, Boss, Jeremy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - biosynthesis Antigens, Surface - genetics Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cells, Cultured Conserved Sequence - immunology Deoxyribonuclease I - metabolism Gene Expression Regulation - immunology Genetic Markers Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Mice, Inbred C57BL NFATC Transcription Factors - metabolism NFATC Transcription Factors - physiology Programmed Cell Death 1 Receptor Protein Transport - genetics Protein Transport - immunology Regulatory Sequences, Nucleic Acid - immunology Transcription, Genetic
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