Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4
Par-4 is a widely expressed protein that sensitizes both prostatic and non-prostatic cells to apoptosis. Constitutive- or regulated- overexpression of Par-4 caused a reduction in the levels of the anti-apoptotic protein Bcl-2. Replenishment of Bcl-2 levels abrogated susceptibility to Par-4-dependent...
Gespeichert in:
| Veröffentlicht in: | Oncogene 1999-01, Vol.18 (3), p.623-631 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 631 |
|---|---|
| container_issue | 3 |
| container_start_page | 623 |
| container_title | Oncogene |
| container_volume | 18 |
| creator | GUOFANG QIU AHMED, M SELLS, S. F MOHIUDDIN, M WEINSTEIN, M. H RANGNEKAR, V. M |
| description | Par-4 is a widely expressed protein that sensitizes both prostatic and non-prostatic cells to apoptosis. Constitutive- or regulated- overexpression of Par-4 caused a reduction in the levels of the anti-apoptotic protein Bcl-2. Replenishment of Bcl-2 levels abrogated susceptibility to Par-4-dependent apoptosis, suggesting that Par-4-mediated apoptosis requires downmodulation of Bcl-2 levels. The inverse correlation between Par-4 and Bcl-2 expression was recapitulated in human prostate tumors. Par-4 but not Bcl-2 was detected in the secretory epithelium of benign prostatic tumors and in primary and metastatic prostate cancers that are apt to undergo apoptosis. Moreover, xenografts of human, androgen-dependent CWR22 tumors showed Par-4 but not Bcl-2 expression. By contrast, androgen-independent CWR22R tumors derived from the CWR22 xenografts showed mutually exclusive expression patterns of Par-4 and Bcl-2. These findings suggest a mechanism by which Par-4 may sensitize prostate tumor cells to apoptosis. |
| doi_str_mv | 10.1038/sj.onc.1202344 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69576571</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69576571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-7e085f415c85482f632e4451a026b889ef9b0ed465a8a765b7cdd21df1b2b0ac3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi1UVJaWKzckHypuWWzHTuxjW_ElFcGBniPHmdCsHGfrsSl754fjaqP2yGkszTOPZvwS8pazLWe1_oC77RLclgsmailfkA2XbVMpZeQJ2TCjWGVELV6R14g7xlhrmDglp8Zoo7nYkL_fcsrW-wOFP85nnH5Dee0jIE5LoHubEsSAdBnplfOVoDYM9IeNlaRToHd5tgWKCyabgKY8LxGpWwJOmCAk-jClOzosD6GK8Ct7mx6lT67-cFSdk5ej9Qhv1npGbj99_Hn9pbr5_vnr9eVN5WrDUtUC02qUXDmtpBZjUwuQUnHLRNNrbWA0PYNBNspq2zaqb90wCD6MvBc9s64-I--P3rLxfQZM3TyhA-9tgCVj1xhVxlr-X5C3gnHDZQG3R9CVP8AIY7eP02zjoeOse8ynw11X8unWfMrAu9Wc-xmGJ3wNpPQv1r5FZ_0YbXATPltbVk439T9XMpn2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17201914</pqid></control><display><type>article</type><title>Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>GUOFANG QIU ; AHMED, M ; SELLS, S. F ; MOHIUDDIN, M ; WEINSTEIN, M. H ; RANGNEKAR, V. M</creator><creatorcontrib>GUOFANG QIU ; AHMED, M ; SELLS, S. F ; MOHIUDDIN, M ; WEINSTEIN, M. H ; RANGNEKAR, V. M</creatorcontrib><description>Par-4 is a widely expressed protein that sensitizes both prostatic and non-prostatic cells to apoptosis. Constitutive- or regulated- overexpression of Par-4 caused a reduction in the levels of the anti-apoptotic protein Bcl-2. Replenishment of Bcl-2 levels abrogated susceptibility to Par-4-dependent apoptosis, suggesting that Par-4-mediated apoptosis requires downmodulation of Bcl-2 levels. The inverse correlation between Par-4 and Bcl-2 expression was recapitulated in human prostate tumors. Par-4 but not Bcl-2 was detected in the secretory epithelium of benign prostatic tumors and in primary and metastatic prostate cancers that are apt to undergo apoptosis. Moreover, xenografts of human, androgen-dependent CWR22 tumors showed Par-4 but not Bcl-2 expression. By contrast, androgen-independent CWR22R tumors derived from the CWR22 xenografts showed mutually exclusive expression patterns of Par-4 and Bcl-2. These findings suggest a mechanism by which Par-4 may sensitize prostate tumor cells to apoptosis.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1202344</identifier><identifier>PMID: 9989812</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>3T3 Cells ; Animals ; Apoptosis ; Apoptosis Regulatory Proteins ; Biological and medical sciences ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cyclin D1 - biosynthesis ; Cyclin D1 - genetics ; Down-Regulation ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Neoplastic ; Humans ; Intracellular Signaling Peptides and Proteins ; Male ; Mice ; Molecular and cellular biology ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology</subject><ispartof>Oncogene, 1999-01, Vol.18 (3), p.623-631</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-7e085f415c85482f632e4451a026b889ef9b0ed465a8a765b7cdd21df1b2b0ac3</citedby><cites>FETCH-LOGICAL-c390t-7e085f415c85482f632e4451a026b889ef9b0ed465a8a765b7cdd21df1b2b0ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1705489$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9989812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUOFANG QIU</creatorcontrib><creatorcontrib>AHMED, M</creatorcontrib><creatorcontrib>SELLS, S. F</creatorcontrib><creatorcontrib>MOHIUDDIN, M</creatorcontrib><creatorcontrib>WEINSTEIN, M. H</creatorcontrib><creatorcontrib>RANGNEKAR, V. M</creatorcontrib><title>Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>Par-4 is a widely expressed protein that sensitizes both prostatic and non-prostatic cells to apoptosis. Constitutive- or regulated- overexpression of Par-4 caused a reduction in the levels of the anti-apoptotic protein Bcl-2. Replenishment of Bcl-2 levels abrogated susceptibility to Par-4-dependent apoptosis, suggesting that Par-4-mediated apoptosis requires downmodulation of Bcl-2 levels. The inverse correlation between Par-4 and Bcl-2 expression was recapitulated in human prostate tumors. Par-4 but not Bcl-2 was detected in the secretory epithelium of benign prostatic tumors and in primary and metastatic prostate cancers that are apt to undergo apoptosis. Moreover, xenografts of human, androgen-dependent CWR22 tumors showed Par-4 but not Bcl-2 expression. By contrast, androgen-independent CWR22R tumors derived from the CWR22 xenografts showed mutually exclusive expression patterns of Par-4 and Bcl-2. These findings suggest a mechanism by which Par-4 may sensitize prostate tumor cells to apoptosis.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis Regulatory Proteins</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Cyclin D1 - biosynthesis</subject><subject>Cyclin D1 - genetics</subject><subject>Down-Regulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Male</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1UVJaWKzckHypuWWzHTuxjW_ElFcGBniPHmdCsHGfrsSl754fjaqP2yGkszTOPZvwS8pazLWe1_oC77RLclgsmailfkA2XbVMpZeQJ2TCjWGVELV6R14g7xlhrmDglp8Zoo7nYkL_fcsrW-wOFP85nnH5Dee0jIE5LoHubEsSAdBnplfOVoDYM9IeNlaRToHd5tgWKCyabgKY8LxGpWwJOmCAk-jClOzosD6GK8Ct7mx6lT67-cFSdk5ej9Qhv1npGbj99_Hn9pbr5_vnr9eVN5WrDUtUC02qUXDmtpBZjUwuQUnHLRNNrbWA0PYNBNspq2zaqb90wCD6MvBc9s64-I--P3rLxfQZM3TyhA-9tgCVj1xhVxlr-X5C3gnHDZQG3R9CVP8AIY7eP02zjoeOse8ynw11X8unWfMrAu9Wc-xmGJ3wNpPQv1r5FZ_0YbXATPltbVk439T9XMpn2</recordid><startdate>19990121</startdate><enddate>19990121</enddate><creator>GUOFANG QIU</creator><creator>AHMED, M</creator><creator>SELLS, S. F</creator><creator>MOHIUDDIN, M</creator><creator>WEINSTEIN, M. H</creator><creator>RANGNEKAR, V. M</creator><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19990121</creationdate><title>Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4</title><author>GUOFANG QIU ; AHMED, M ; SELLS, S. F ; MOHIUDDIN, M ; WEINSTEIN, M. H ; RANGNEKAR, V. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-7e085f415c85482f632e4451a026b889ef9b0ed465a8a765b7cdd21df1b2b0ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>3T3 Cells</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis Regulatory Proteins</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Cyclin D1 - biosynthesis</topic><topic>Cyclin D1 - genetics</topic><topic>Down-Regulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Male</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUOFANG QIU</creatorcontrib><creatorcontrib>AHMED, M</creatorcontrib><creatorcontrib>SELLS, S. F</creatorcontrib><creatorcontrib>MOHIUDDIN, M</creatorcontrib><creatorcontrib>WEINSTEIN, M. H</creatorcontrib><creatorcontrib>RANGNEKAR, V. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUOFANG QIU</au><au>AHMED, M</au><au>SELLS, S. F</au><au>MOHIUDDIN, M</au><au>WEINSTEIN, M. H</au><au>RANGNEKAR, V. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4</atitle><jtitle>Oncogene</jtitle><addtitle>Oncogene</addtitle><date>1999-01-21</date><risdate>1999</risdate><volume>18</volume><issue>3</issue><spage>623</spage><epage>631</epage><pages>623-631</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><abstract>Par-4 is a widely expressed protein that sensitizes both prostatic and non-prostatic cells to apoptosis. Constitutive- or regulated- overexpression of Par-4 caused a reduction in the levels of the anti-apoptotic protein Bcl-2. Replenishment of Bcl-2 levels abrogated susceptibility to Par-4-dependent apoptosis, suggesting that Par-4-mediated apoptosis requires downmodulation of Bcl-2 levels. The inverse correlation between Par-4 and Bcl-2 expression was recapitulated in human prostate tumors. Par-4 but not Bcl-2 was detected in the secretory epithelium of benign prostatic tumors and in primary and metastatic prostate cancers that are apt to undergo apoptosis. Moreover, xenografts of human, androgen-dependent CWR22 tumors showed Par-4 but not Bcl-2 expression. By contrast, androgen-independent CWR22R tumors derived from the CWR22 xenografts showed mutually exclusive expression patterns of Par-4 and Bcl-2. These findings suggest a mechanism by which Par-4 may sensitize prostate tumor cells to apoptosis.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>9989812</pmid><doi>10.1038/sj.onc.1202344</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9232 |
| ispartof | Oncogene, 1999-01, Vol.18 (3), p.623-631 |
| issn | 0950-9232 1476-5594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69576571 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 3T3 Cells Animals Apoptosis Apoptosis Regulatory Proteins Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin D1 - biosynthesis Cyclin D1 - genetics Down-Regulation Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Humans Intracellular Signaling Peptides and Proteins Male Mice Molecular and cellular biology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology |
| title | Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T11%3A13%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mutually%20exclusive%20expression%20patterns%20of%20Bcl-2%20and%20Par-4%20in%20human%20prostate%20tumors%20consistent%20with%20down-regulation%20of%20Bcl-2%20by%20Par-4&rft.jtitle=Oncogene&rft.au=GUOFANG%20QIU&rft.date=1999-01-21&rft.volume=18&rft.issue=3&rft.spage=623&rft.epage=631&rft.pages=623-631&rft.issn=0950-9232&rft.eissn=1476-5594&rft_id=info:doi/10.1038/sj.onc.1202344&rft_dat=%3Cproquest_cross%3E69576571%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17201914&rft_id=info:pmid/9989812&rfr_iscdi=true |