CGRP Activates Renal Pelvic Substance P Receptors by Retarding Substance P Metabolism

Substance P and calcitonin gene-related peptide (CGRP) are colocalized in renal pelvic sensory nerves. Increasing renal pelvic pressure results in an increase in afferent renal nerve activity that is blocked by a substance P receptor antagonist but not by a CGRP receptor antagonist. CGRP potentiates...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-01, Vol.33 (1S Suppl), p.493-498
Hauptverfasser:	Gontijo, Jose R, Smith, Lori A, Kopp, Ulla C
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - drug effects Afferent Pathways - physiology Animals Biological and medical sciences Calcitonin Gene-Related Peptide - pharmacology Fundamental and applied biological sciences. Psychology Indoles - pharmacology Isoindoles Kidney - innervation Kidney Pelvis - drug effects Kidney Pelvis - metabolism Male Rats Rats, Sprague-Dawley Receptors, Neurokinin-1 - drug effects Receptors, Neurokinin-1 - metabolism Substance P - metabolism Thiorphan - pharmacology Vertebrates: urinary system
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