MLL-AF1q fusion resulting from t(1;11) in acute leukemia
The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, inc...
Gespeichert in:
| Veröffentlicht in: | Leukemia 1999-02, Vol.13 (2), p.302-306 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 306 |
|---|---|
| container_issue | 2 |
| container_start_page | 302 |
| container_title | Leukemia |
| container_volume | 13 |
| creator | CONIAT, M. B.-L SALOMON-NGUYEN, F HILLION, J BERNARD, O. A BERGER, R |
| description | The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement. |
| doi_str_mv | 10.1038/sj.leu.2401299 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69575370</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69575370</sourcerecordid><originalsourceid>FETCH-LOGICAL-c309t-98d745eb36bc265bed7964f0c9bf51efe619a437b288205b5d349c68aeb5f4fd3</originalsourceid><addsrcrecordid>eNpd0EtLAzEUBeAgiq3VrUsZUEQXU_N-0FUpVoURN7oekkwiU-fRJpOF_94RK4Kruzgf9x4uAOcIzhEk8i5u5o1Lc0whwkodgCmigueMMXQIplBKkXOF6QScxLiB8Dvkx2CCIMRMQTEF8rko8uUa7TKfYt13WXAxNUPdvWc-9G023KAFQrdZ3WXapsFl47UP19b6FBx53UR3tp8z8La-f1095sXLw9NqWeSWQDXkSlaCMmcINxZzZlwlFKceWmU8Q847jpSmRBgsJYbMsIpQZbnUzjBPfUVm4Ppn7zb0u-TiULZ1tK5pdOf6FEuumGBEwBFe_oObPoVu7FZiThlXHEk-qou9SqZ1VbkNdavDZ_n7kRFc7YGOVjc-6M7W8c-J0TFCvgCWFmyQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2645696186</pqid></control><display><type>article</type><title>MLL-AF1q fusion resulting from t(1;11) in acute leukemia</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>CONIAT, M. B.-L ; SALOMON-NGUYEN, F ; HILLION, J ; BERNARD, O. A ; BERGER, R</creator><creatorcontrib>CONIAT, M. B.-L ; SALOMON-NGUYEN, F ; HILLION, J ; BERNARD, O. A ; BERGER, R</creatorcontrib><description>The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/sj.leu.2401299</identifier><identifier>PMID: 10025907</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Artificial Gene Fusion ; Base Sequence ; Biological and medical sciences ; Child, Preschool ; Chromosome translocations ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 11 ; Cytogenetics ; Female ; Fusion protein ; Hematologic and hematopoietic diseases ; Humans ; In Situ Hybridization, Fluorescence ; Infant ; Karyotyping ; Leukemia ; Leukemia, Myelomonocytic, Acute - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; MLL protein ; Molecular Sequence Data ; Monocytes ; mRNA ; Translocation ; Translocation, Genetic</subject><ispartof>Leukemia, 1999-02, Vol.13 (2), p.302-306</ispartof><rights>1999 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-98d745eb36bc265bed7964f0c9bf51efe619a437b288205b5d349c68aeb5f4fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1702553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10025907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CONIAT, M. B.-L</creatorcontrib><creatorcontrib>SALOMON-NGUYEN, F</creatorcontrib><creatorcontrib>HILLION, J</creatorcontrib><creatorcontrib>BERNARD, O. A</creatorcontrib><creatorcontrib>BERGER, R</creatorcontrib><title>MLL-AF1q fusion resulting from t(1;11) in acute leukemia</title><title>Leukemia</title><addtitle>Leukemia</addtitle><description>The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.</description><subject>Artificial Gene Fusion</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Chromosome translocations</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Cytogenetics</subject><subject>Female</subject><subject>Fusion protein</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Infant</subject><subject>Karyotyping</subject><subject>Leukemia</subject><subject>Leukemia, Myelomonocytic, Acute - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MLL protein</subject><subject>Molecular Sequence Data</subject><subject>Monocytes</subject><subject>mRNA</subject><subject>Translocation</subject><subject>Translocation, Genetic</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0EtLAzEUBeAgiq3VrUsZUEQXU_N-0FUpVoURN7oekkwiU-fRJpOF_94RK4Kruzgf9x4uAOcIzhEk8i5u5o1Lc0whwkodgCmigueMMXQIplBKkXOF6QScxLiB8Dvkx2CCIMRMQTEF8rko8uUa7TKfYt13WXAxNUPdvWc-9G023KAFQrdZ3WXapsFl47UP19b6FBx53UR3tp8z8La-f1095sXLw9NqWeSWQDXkSlaCMmcINxZzZlwlFKceWmU8Q847jpSmRBgsJYbMsIpQZbnUzjBPfUVm4Ppn7zb0u-TiULZ1tK5pdOf6FEuumGBEwBFe_oObPoVu7FZiThlXHEk-qou9SqZ1VbkNdavDZ_n7kRFc7YGOVjc-6M7W8c-J0TFCvgCWFmyQ</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>CONIAT, M. B.-L</creator><creator>SALOMON-NGUYEN, F</creator><creator>HILLION, J</creator><creator>BERNARD, O. A</creator><creator>BERGER, R</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>MLL-AF1q fusion resulting from t(1;11) in acute leukemia</title><author>CONIAT, M. B.-L ; SALOMON-NGUYEN, F ; HILLION, J ; BERNARD, O. A ; BERGER, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-98d745eb36bc265bed7964f0c9bf51efe619a437b288205b5d349c68aeb5f4fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Artificial Gene Fusion</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Chromosome translocations</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Cytogenetics</topic><topic>Female</topic><topic>Fusion protein</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Infant</topic><topic>Karyotyping</topic><topic>Leukemia</topic><topic>Leukemia, Myelomonocytic, Acute - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MLL protein</topic><topic>Molecular Sequence Data</topic><topic>Monocytes</topic><topic>mRNA</topic><topic>Translocation</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CONIAT, M. B.-L</creatorcontrib><creatorcontrib>SALOMON-NGUYEN, F</creatorcontrib><creatorcontrib>HILLION, J</creatorcontrib><creatorcontrib>BERNARD, O. A</creatorcontrib><creatorcontrib>BERGER, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CONIAT, M. B.-L</au><au>SALOMON-NGUYEN, F</au><au>HILLION, J</au><au>BERNARD, O. A</au><au>BERGER, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MLL-AF1q fusion resulting from t(1;11) in acute leukemia</atitle><jtitle>Leukemia</jtitle><addtitle>Leukemia</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>13</volume><issue>2</issue><spage>302</spage><epage>306</epage><pages>302-306</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>10025907</pmid><doi>10.1038/sj.leu.2401299</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 1999-02, Vol.13 (2), p.302-306 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69575370 |
| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Artificial Gene Fusion Base Sequence Biological and medical sciences Child, Preschool Chromosome translocations Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 11 Cytogenetics Female Fusion protein Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Infant Karyotyping Leukemia Leukemia, Myelomonocytic, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences MLL protein Molecular Sequence Data Monocytes mRNA Translocation Translocation, Genetic |
| title | MLL-AF1q fusion resulting from t(1;11) in acute leukemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T20%3A53%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MLL-AF1q%20fusion%20resulting%20from%20t(1;11)%20in%20acute%20leukemia&rft.jtitle=Leukemia&rft.au=CONIAT,%20M.%20B.-L&rft.date=1999-02-01&rft.volume=13&rft.issue=2&rft.spage=302&rft.epage=306&rft.pages=302-306&rft.issn=0887-6924&rft.eissn=1476-5551&rft.coden=LEUKED&rft_id=info:doi/10.1038/sj.leu.2401299&rft_dat=%3Cproquest_pubme%3E69575370%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2645696186&rft_id=info:pmid/10025907&rfr_iscdi=true |