Three-Dimensional Quantitative Structure−Activity Relationship of Interleukin 1-β Converting Enzyme Inhibitors:  A Comparative Molecular Field Analysis Study

A three-dimensional quantitative structure−activity relationship (QSAR) study using the comparative molecular field analysis (CoMFA) method was performed on a series of interleukin 1-β converting enzyme (ICE) inhibitors. The compounds studied have been reported to be time-dependent inhibitors of ICE...

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Veröffentlicht in:	Journal of medicinal chemistry 1999-02, Vol.42 (3), p.373-380
Hauptverfasser:	Kulkarni, Santosh S, Kulkarni, Vithal M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Caspase Inhibitors Crystallography, X-Ray Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - pharmacology Kinetics Magnetic Resonance Spectroscopy Medical sciences Models, Molecular Pharmacology. Drug treatments Structure-Activity Relationship
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