Human Autoantibodies against HD1/Plectin in Paraneoplastic Pemphigus
Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with underlying neoplasms. PNP patients develop characteristic autoantibodies directed against multiple antigens, mostly identified as members of the plakin family of cytoplasmic proteins (desmoplakin I and...
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| Veröffentlicht in: | Journal of investigative dermatology 1999-02, Vol.112 (2), p.153-156 |
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| creator | Proby, Charlotte Fujii, Yoshiko Nishikawa, Takeji Amagai, Masayuki Owaribe, Katsushi |
| description | Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with underlying neoplasms. PNP patients develop characteristic autoantibodies directed against multiple antigens, mostly identified as members of the plakin family of cytoplasmic proteins (desmoplakin I and II, bullous pemphigoid antigen I, envoplakin, and periplakin). HD1/plectin, another member of the plakin family, has not previously been detected in the characteristic PNP antigen complex, which may relate to practical difficulties associated with its large size (molecular weight ≈ 500 kDa). In this study, a combination of immunoprecipitation and immunoblot is used to demonstrate that HD1/plectin is also recognized by sera from PNP patients. Thirteen of 16 PNP sera tested were positive for HD1/plectin compared with none of 43 control sera (11 pemphigus vulgaris, 11 pemphigus foliaceus, 11 bullous pemphigoid, and 10 normal individuals). Combined with our recent finding that desmoglein 3 and desmoglein 1 are cell surface target antigens in PNP, this demonstration of plectin/HD1 as another component of the antigen complex in PNP confirms that PNP is an autoimmune disease against desmoglein and plakin family molecules. |
| doi_str_mv | 10.1046/j.1523-1747.1999.00498.x |
| format | Article |
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PNP patients develop characteristic autoantibodies directed against multiple antigens, mostly identified as members of the plakin family of cytoplasmic proteins (desmoplakin I and II, bullous pemphigoid antigen I, envoplakin, and periplakin). HD1/plectin, another member of the plakin family, has not previously been detected in the characteristic PNP antigen complex, which may relate to practical difficulties associated with its large size (molecular weight ≈ 500 kDa). In this study, a combination of immunoprecipitation and immunoblot is used to demonstrate that HD1/plectin is also recognized by sera from PNP patients. Thirteen of 16 PNP sera tested were positive for HD1/plectin compared with none of 43 control sera (11 pemphigus vulgaris, 11 pemphigus foliaceus, 11 bullous pemphigoid, and 10 normal individuals). Combined with our recent finding that desmoglein 3 and desmoglein 1 are cell surface target antigens in PNP, this demonstration of plectin/HD1 as another component of the antigen complex in PNP confirms that PNP is an autoimmune disease against desmoglein and plakin family molecules.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1046/j.1523-1747.1999.00498.x</identifier><identifier>PMID: 9989789</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Autoantibodies - immunology ; autoimmunity ; Biological and medical sciences ; Bullous diseases of the skin ; Dermatology ; desmoglein ; Humans ; Immunoblotting ; Intermediate Filament Proteins - immunology ; Medical sciences ; Paraneoplastic Syndromes - blood ; Paraneoplastic Syndromes - immunology ; Pemphigus - blood ; Pemphigus - immunology ; plakins ; Plectin ; Precipitin Tests</subject><ispartof>Journal of investigative dermatology, 1999-02, Vol.112 (2), p.153-156</ispartof><rights>1999 The Society for Investigative Dermatology, Inc</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-1bf26be70c726fd1fc4e3099245b6795c75e69e270f1764cc74e23e4626b600e3</citedby><cites>FETCH-LOGICAL-c448t-1bf26be70c726fd1fc4e3099245b6795c75e69e270f1764cc74e23e4626b600e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1662441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9989789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Proby, Charlotte</creatorcontrib><creatorcontrib>Fujii, Yoshiko</creatorcontrib><creatorcontrib>Nishikawa, Takeji</creatorcontrib><creatorcontrib>Amagai, Masayuki</creatorcontrib><creatorcontrib>Owaribe, Katsushi</creatorcontrib><title>Human Autoantibodies against HD1/Plectin in Paraneoplastic Pemphigus</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with underlying neoplasms. PNP patients develop characteristic autoantibodies directed against multiple antigens, mostly identified as members of the plakin family of cytoplasmic proteins (desmoplakin I and II, bullous pemphigoid antigen I, envoplakin, and periplakin). HD1/plectin, another member of the plakin family, has not previously been detected in the characteristic PNP antigen complex, which may relate to practical difficulties associated with its large size (molecular weight ≈ 500 kDa). In this study, a combination of immunoprecipitation and immunoblot is used to demonstrate that HD1/plectin is also recognized by sera from PNP patients. Thirteen of 16 PNP sera tested were positive for HD1/plectin compared with none of 43 control sera (11 pemphigus vulgaris, 11 pemphigus foliaceus, 11 bullous pemphigoid, and 10 normal individuals). Combined with our recent finding that desmoglein 3 and desmoglein 1 are cell surface target antigens in PNP, this demonstration of plectin/HD1 as another component of the antigen complex in PNP confirms that PNP is an autoimmune disease against desmoglein and plakin family molecules.</description><subject>Autoantibodies - immunology</subject><subject>autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Bullous diseases of the skin</subject><subject>Dermatology</subject><subject>desmoglein</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Intermediate Filament Proteins - immunology</subject><subject>Medical sciences</subject><subject>Paraneoplastic Syndromes - blood</subject><subject>Paraneoplastic Syndromes - immunology</subject><subject>Pemphigus - blood</subject><subject>Pemphigus - immunology</subject><subject>plakins</subject><subject>Plectin</subject><subject>Precipitin Tests</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc05_gtAL8a41SdOkuZybOmHgLhS8C2l6OjP6MZtW5r83dWNeCoFz8T7vyeFBKCA4Ipjxu01EEhqHRDARESllhDGTabQ7QeNjcIrGGFMaUkzfz9GFcxuMCWdJOkIjKVMpUjlG80Vf6TqY9l2j685mTW7BBXqtbe26YDEnd6sSTGfrwL-VbnUNzbbUrrMmWEG1_bDr3l2is0KXDq4Oc4LeHh9eZ4tw-fL0PJsuQ8NY2oUkKyjPQGAjKC9yUhgGMZaSsiTjQiZGJMAlUIELIjgzRjCgMTDuWxxjiCfodr932zafPbhOVdYZKMvhqt4pLhPhaerBdA-atnGuhUJtW1vp9lsRrAaBaqMGT2rwpAaB6leg2vnq9eGPPqsgPxYPxnx-c8i1M7osvBFj3d9-ziljxGP3ewy8jy8LrXLGQm0gt633qfLG_n_LDwATjh8</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Proby, Charlotte</creator><creator>Fujii, Yoshiko</creator><creator>Nishikawa, Takeji</creator><creator>Amagai, Masayuki</creator><creator>Owaribe, Katsushi</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990201</creationdate><title>Human Autoantibodies against HD1/Plectin in Paraneoplastic Pemphigus</title><author>Proby, Charlotte ; Fujii, Yoshiko ; Nishikawa, Takeji ; Amagai, Masayuki ; Owaribe, Katsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-1bf26be70c726fd1fc4e3099245b6795c75e69e270f1764cc74e23e4626b600e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Autoantibodies - immunology</topic><topic>autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Bullous diseases of the skin</topic><topic>Dermatology</topic><topic>desmoglein</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Intermediate Filament Proteins - immunology</topic><topic>Medical sciences</topic><topic>Paraneoplastic Syndromes - blood</topic><topic>Paraneoplastic Syndromes - immunology</topic><topic>Pemphigus - blood</topic><topic>Pemphigus - immunology</topic><topic>plakins</topic><topic>Plectin</topic><topic>Precipitin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Proby, Charlotte</creatorcontrib><creatorcontrib>Fujii, Yoshiko</creatorcontrib><creatorcontrib>Nishikawa, Takeji</creatorcontrib><creatorcontrib>Amagai, Masayuki</creatorcontrib><creatorcontrib>Owaribe, Katsushi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Proby, Charlotte</au><au>Fujii, Yoshiko</au><au>Nishikawa, Takeji</au><au>Amagai, Masayuki</au><au>Owaribe, Katsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Autoantibodies against HD1/Plectin in Paraneoplastic Pemphigus</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>112</volume><issue>2</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with underlying neoplasms. PNP patients develop characteristic autoantibodies directed against multiple antigens, mostly identified as members of the plakin family of cytoplasmic proteins (desmoplakin I and II, bullous pemphigoid antigen I, envoplakin, and periplakin). HD1/plectin, another member of the plakin family, has not previously been detected in the characteristic PNP antigen complex, which may relate to practical difficulties associated with its large size (molecular weight ≈ 500 kDa). In this study, a combination of immunoprecipitation and immunoblot is used to demonstrate that HD1/plectin is also recognized by sera from PNP patients. Thirteen of 16 PNP sera tested were positive for HD1/plectin compared with none of 43 control sera (11 pemphigus vulgaris, 11 pemphigus foliaceus, 11 bullous pemphigoid, and 10 normal individuals). Combined with our recent finding that desmoglein 3 and desmoglein 1 are cell surface target antigens in PNP, this demonstration of plectin/HD1 as another component of the antigen complex in PNP confirms that PNP is an autoimmune disease against desmoglein and plakin family molecules.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>9989789</pmid><doi>10.1046/j.1523-1747.1999.00498.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autoantibodies - immunology autoimmunity Biological and medical sciences Bullous diseases of the skin Dermatology desmoglein Humans Immunoblotting Intermediate Filament Proteins - immunology Medical sciences Paraneoplastic Syndromes - blood Paraneoplastic Syndromes - immunology Pemphigus - blood Pemphigus - immunology plakins Plectin Precipitin Tests |
| title | Human Autoantibodies against HD1/Plectin in Paraneoplastic Pemphigus |
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