Dermorphin and Deltorphin Glycosylated Analogues: Synthesis and Antinociceptive Activity after Systemic Administration
In the present paper we describe the synthesis of some dermorphin and deltorphin analogues β-O- and α-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.
Gespeichert in:
| Veröffentlicht in: | Journal of medicinal chemistry 1999-02, Vol.42 (3), p.400-404 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 404 |
|---|---|
| container_issue | 3 |
| container_start_page | 400 |
| container_title | Journal of medicinal chemistry |
| container_volume | 42 |
| creator | Negri, Lucia Lattanzi, Roberta Tabacco, Fabio Orrù, Luigi Severini, Cinzia Scolaro, Barbara Rocchi, Raniero |
| description | In the present paper we describe the synthesis of some dermorphin and deltorphin analogues β-O- and α-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice. |
| doi_str_mv | 10.1021/jm9810699 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69573663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69573663</sourcerecordid><originalsourceid>FETCH-LOGICAL-a377t-1e27414302e22fcce25e23d90543d74897282ff7f9cfec3471920c62320e09c83</originalsourceid><addsrcrecordid>eNptkcFu1DAQhi0EKtvCgQdAygEqcQiM7SSOuUW7tCBVgNRytowzpl4SZ2t7Eblx5TV5EgwbLRdOo9H_za-Zfwh5QuElBUZfbUfZUmikvEdWtGZQVi1U98kKgLGSNYw_JKcxbgGAU8ZPyImUbSMorMi8wTBOYXfrfKF9X2xwSEt7OcxmivOgE_ZF5_UwfdljfP3rx8_ievbpFqOLf2c6n5yfjDO4S-4bFp3JxaW50DZhyHBMODpTdP3ovIsp6OQm_4g8sHqI-HipZ-TTxZub9dvy6sPlu3V3VWouRCopMlHRigNDxqwxyGpkvJdQV7wXVSsFa5m1wkpj0fBKUMnA5JMZIEjT8jNyfvDdhekuH5DU6KLBYdAep31UjawFbxqewRcH0IQpxoBW7YIbdZgVBfUnZnWMObNPF9P95xH7I7nkmvVni66j0YMN2hsX_xkKBhXQjJUHLKeC34-yDl9VI7io1c3Ha7WWF6Jp1-_VJvPPD7w2UW2nfchfif9Z7zfV3aFv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69573663</pqid></control><display><type>article</type><title>Dermorphin and Deltorphin Glycosylated Analogues: Synthesis and Antinociceptive Activity after Systemic Administration</title><source>MEDLINE</source><source>ACS Publications</source><creator>Negri, Lucia ; Lattanzi, Roberta ; Tabacco, Fabio ; Orrù, Luigi ; Severini, Cinzia ; Scolaro, Barbara ; Rocchi, Raniero</creator><creatorcontrib>Negri, Lucia ; Lattanzi, Roberta ; Tabacco, Fabio ; Orrù, Luigi ; Severini, Cinzia ; Scolaro, Barbara ; Rocchi, Raniero</creatorcontrib><description>In the present paper we describe the synthesis of some dermorphin and deltorphin analogues β-O- and α-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm9810699</identifier><identifier>PMID: 9986710</identifier><identifier>CODEN: JMCMAR</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Amino Acid Sequence ; Analgesics ; Analgesics, Opioid - chemical synthesis ; Analgesics, Opioid - chemistry ; Analgesics, Opioid - pharmacology ; Animals ; Biological and medical sciences ; Glycosylation ; Guinea Pigs ; In Vitro Techniques ; Injections, Subcutaneous ; Male ; Medical sciences ; Mice ; Muscle, Smooth - drug effects ; Neuropharmacology ; Oligopeptides - chemical synthesis ; Oligopeptides - chemistry ; Oligopeptides - pharmacology ; Opioid Peptides ; Pharmacology. Drug treatments ; Receptors, Opioid - drug effects</subject><ispartof>Journal of medicinal chemistry, 1999-02, Vol.42 (3), p.400-404</ispartof><rights>Copyright © 1999 American Chemical Society</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a377t-1e27414302e22fcce25e23d90543d74897282ff7f9cfec3471920c62320e09c83</citedby><cites>FETCH-LOGICAL-a377t-1e27414302e22fcce25e23d90543d74897282ff7f9cfec3471920c62320e09c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm9810699$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm9810699$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1720401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9986710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Negri, Lucia</creatorcontrib><creatorcontrib>Lattanzi, Roberta</creatorcontrib><creatorcontrib>Tabacco, Fabio</creatorcontrib><creatorcontrib>Orrù, Luigi</creatorcontrib><creatorcontrib>Severini, Cinzia</creatorcontrib><creatorcontrib>Scolaro, Barbara</creatorcontrib><creatorcontrib>Rocchi, Raniero</creatorcontrib><title>Dermorphin and Deltorphin Glycosylated Analogues: Synthesis and Antinociceptive Activity after Systemic Administration</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>In the present paper we describe the synthesis of some dermorphin and deltorphin analogues β-O- and α-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.</description><subject>Amino Acid Sequence</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - chemical synthesis</subject><subject>Analgesics, Opioid - chemistry</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Glycosylation</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Muscle, Smooth - drug effects</subject><subject>Neuropharmacology</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Oligopeptides - chemistry</subject><subject>Oligopeptides - pharmacology</subject><subject>Opioid Peptides</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Opioid - drug effects</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFu1DAQhi0EKtvCgQdAygEqcQiM7SSOuUW7tCBVgNRytowzpl4SZ2t7Eblx5TV5EgwbLRdOo9H_za-Zfwh5QuElBUZfbUfZUmikvEdWtGZQVi1U98kKgLGSNYw_JKcxbgGAU8ZPyImUbSMorMi8wTBOYXfrfKF9X2xwSEt7OcxmivOgE_ZF5_UwfdljfP3rx8_ievbpFqOLf2c6n5yfjDO4S-4bFp3JxaW50DZhyHBMODpTdP3ovIsp6OQm_4g8sHqI-HipZ-TTxZub9dvy6sPlu3V3VWouRCopMlHRigNDxqwxyGpkvJdQV7wXVSsFa5m1wkpj0fBKUMnA5JMZIEjT8jNyfvDdhekuH5DU6KLBYdAep31UjawFbxqewRcH0IQpxoBW7YIbdZgVBfUnZnWMObNPF9P95xH7I7nkmvVni66j0YMN2hsX_xkKBhXQjJUHLKeC34-yDl9VI7io1c3Ha7WWF6Jp1-_VJvPPD7w2UW2nfchfif9Z7zfV3aFv</recordid><startdate>19990211</startdate><enddate>19990211</enddate><creator>Negri, Lucia</creator><creator>Lattanzi, Roberta</creator><creator>Tabacco, Fabio</creator><creator>Orrù, Luigi</creator><creator>Severini, Cinzia</creator><creator>Scolaro, Barbara</creator><creator>Rocchi, Raniero</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990211</creationdate><title>Dermorphin and Deltorphin Glycosylated Analogues: Synthesis and Antinociceptive Activity after Systemic Administration</title><author>Negri, Lucia ; Lattanzi, Roberta ; Tabacco, Fabio ; Orrù, Luigi ; Severini, Cinzia ; Scolaro, Barbara ; Rocchi, Raniero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a377t-1e27414302e22fcce25e23d90543d74897282ff7f9cfec3471920c62320e09c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino Acid Sequence</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - chemical synthesis</topic><topic>Analgesics, Opioid - chemistry</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Glycosylation</topic><topic>Guinea Pigs</topic><topic>In Vitro Techniques</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Muscle, Smooth - drug effects</topic><topic>Neuropharmacology</topic><topic>Oligopeptides - chemical synthesis</topic><topic>Oligopeptides - chemistry</topic><topic>Oligopeptides - pharmacology</topic><topic>Opioid Peptides</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, Opioid - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Negri, Lucia</creatorcontrib><creatorcontrib>Lattanzi, Roberta</creatorcontrib><creatorcontrib>Tabacco, Fabio</creatorcontrib><creatorcontrib>Orrù, Luigi</creatorcontrib><creatorcontrib>Severini, Cinzia</creatorcontrib><creatorcontrib>Scolaro, Barbara</creatorcontrib><creatorcontrib>Rocchi, Raniero</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Negri, Lucia</au><au>Lattanzi, Roberta</au><au>Tabacco, Fabio</au><au>Orrù, Luigi</au><au>Severini, Cinzia</au><au>Scolaro, Barbara</au><au>Rocchi, Raniero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dermorphin and Deltorphin Glycosylated Analogues: Synthesis and Antinociceptive Activity after Systemic Administration</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. Med. Chem</addtitle><date>1999-02-11</date><risdate>1999</risdate><volume>42</volume><issue>3</issue><spage>400</spage><epage>404</epage><pages>400-404</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><coden>JMCMAR</coden><abstract>In the present paper we describe the synthesis of some dermorphin and deltorphin analogues β-O- and α-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>9986710</pmid><doi>10.1021/jm9810699</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1999-02, Vol.42 (3), p.400-404 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69573663 |
| source | MEDLINE; ACS Publications |
| subjects | Amino Acid Sequence Analgesics Analgesics, Opioid - chemical synthesis Analgesics, Opioid - chemistry Analgesics, Opioid - pharmacology Animals Biological and medical sciences Glycosylation Guinea Pigs In Vitro Techniques Injections, Subcutaneous Male Medical sciences Mice Muscle, Smooth - drug effects Neuropharmacology Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Opioid Peptides Pharmacology. Drug treatments Receptors, Opioid - drug effects |
| title | Dermorphin and Deltorphin Glycosylated Analogues: Synthesis and Antinociceptive Activity after Systemic Administration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T23%3A37%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dermorphin%20and%20Deltorphin%20Glycosylated%20Analogues:%E2%80%89%20Synthesis%20and%20Antinociceptive%20Activity%20after%20Systemic%20Administration&rft.jtitle=Journal%20of%20medicinal%20chemistry&rft.au=Negri,%20Lucia&rft.date=1999-02-11&rft.volume=42&rft.issue=3&rft.spage=400&rft.epage=404&rft.pages=400-404&rft.issn=0022-2623&rft.eissn=1520-4804&rft.coden=JMCMAR&rft_id=info:doi/10.1021/jm9810699&rft_dat=%3Cproquest_cross%3E69573663%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69573663&rft_id=info:pmid/9986710&rfr_iscdi=true |