Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis
To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA). Patients included in the Italian ETN registry who had a standard radiograph of both...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2008-07, Vol.26 (4), p.688-692 |
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| creator | NIELSEN, S RUPERTO, N BARCELLONA, R GALLIZZI, R ROSSI, F MAGNI-MANZONI, S LOMBARDINI, G FILOCAMO, G RASCHETTI, R MARTINI, A RAVELLI, A GERLONI, V SIMONINI, G CORTIS, E LEPORE, L ALPIGIANI, M. G ZULIAN, F CORONA, F ALESSIO, M |
| description | To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA).
Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs.
A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression.
Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial. |
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Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs.
A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression.
Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.</description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 18799107</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Arthritis, Juvenile - diagnostic imaging ; Arthritis, Juvenile - drug therapy ; Biological and medical sciences ; Child ; Child, Preschool ; Diseases of the osteoarticular system ; Etanercept ; Female ; Humans ; Immunoglobulin G - therapeutic use ; Immunomodulators ; Immunosuppressive Agents - therapeutic use ; Inflammatory joint diseases ; Male ; Medical sciences ; Metacarpal Bones - diagnostic imaging ; Pharmacology. Drug treatments ; Radiography ; Receptors, Tumor Necrosis Factor - therapeutic use ; Registries ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>Clinical and experimental rheumatology, 2008-07, Vol.26 (4), p.688-692</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20687727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18799107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NIELSEN, S</creatorcontrib><creatorcontrib>RUPERTO, N</creatorcontrib><creatorcontrib>BARCELLONA, R</creatorcontrib><creatorcontrib>GALLIZZI, R</creatorcontrib><creatorcontrib>ROSSI, F</creatorcontrib><creatorcontrib>MAGNI-MANZONI, S</creatorcontrib><creatorcontrib>LOMBARDINI, G</creatorcontrib><creatorcontrib>FILOCAMO, G</creatorcontrib><creatorcontrib>RASCHETTI, R</creatorcontrib><creatorcontrib>MARTINI, A</creatorcontrib><creatorcontrib>RAVELLI, A</creatorcontrib><creatorcontrib>GERLONI, V</creatorcontrib><creatorcontrib>SIMONINI, G</creatorcontrib><creatorcontrib>CORTIS, E</creatorcontrib><creatorcontrib>LEPORE, L</creatorcontrib><creatorcontrib>ALPIGIANI, M. G</creatorcontrib><creatorcontrib>ZULIAN, F</creatorcontrib><creatorcontrib>CORONA, F</creatorcontrib><creatorcontrib>ALESSIO, M</creatorcontrib><creatorcontrib>Italian Pediatric Rheumatology Study Group</creatorcontrib><title>Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA).
Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs.
A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression.
Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.</description><subject>Arthritis, Juvenile - diagnostic imaging</subject><subject>Arthritis, Juvenile - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diseases of the osteoarticular system</subject><subject>Etanercept</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - therapeutic use</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metacarpal Bones - diagnostic imaging</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiography</subject><subject>Receptors, Tumor Necrosis Factor - therapeutic use</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E1LAzEQBuAgiq3VvyC56G0hu2m-jlL8goIeFHpb0slsm7K7XZNsof_eiNXTDMzDMPOekWkpDC-Y0atzMmXcVIUWcjUhVzHuGKukkOqSTEqtjCmZmhL_HrD1ne9tOFI8eIc9IE1bmygm22MAHBLt7JEGdGMeBev8fhPssPVAh5BbjNHve-p7uhsP2PsWqc9msOmH2JC2wScfr8lFY9uIN6c6I59Pjx-Ll2L59vy6eFgWm3xdKhpmQaJlAucgdDlHDhqVQm7FPL_F1wAlBzBVYwSABlWhQ6VN5Tg455DPyP3v3nzc14gx1Z2PgG2bv9mPsZZGKM6lzPD2BMd1h64egu9yCvVfOBncnYCNYNsm2B58_HcVk1qpSvFv2Ctyeg</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>NIELSEN, S</creator><creator>RUPERTO, N</creator><creator>BARCELLONA, R</creator><creator>GALLIZZI, R</creator><creator>ROSSI, F</creator><creator>MAGNI-MANZONI, S</creator><creator>LOMBARDINI, G</creator><creator>FILOCAMO, G</creator><creator>RASCHETTI, R</creator><creator>MARTINI, A</creator><creator>RAVELLI, A</creator><creator>GERLONI, V</creator><creator>SIMONINI, G</creator><creator>CORTIS, E</creator><creator>LEPORE, L</creator><creator>ALPIGIANI, M. G</creator><creator>ZULIAN, F</creator><creator>CORONA, F</creator><creator>ALESSIO, M</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis</title><author>NIELSEN, S ; RUPERTO, N ; BARCELLONA, R ; GALLIZZI, R ; ROSSI, F ; MAGNI-MANZONI, S ; LOMBARDINI, G ; FILOCAMO, G ; RASCHETTI, R ; MARTINI, A ; RAVELLI, A ; GERLONI, V ; SIMONINI, G ; CORTIS, E ; LEPORE, L ; ALPIGIANI, M. G ; ZULIAN, F ; CORONA, F ; ALESSIO, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g265t-f0ac6ea05e4c5814e3c8e77e3a540983bcc13cc92f95cc8c72ede7892d3cddde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Arthritis, Juvenile - diagnostic imaging</topic><topic>Arthritis, Juvenile - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diseases of the osteoarticular system</topic><topic>Etanercept</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - therapeutic use</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metacarpal Bones - diagnostic imaging</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiography</topic><topic>Receptors, Tumor Necrosis Factor - therapeutic use</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NIELSEN, S</creatorcontrib><creatorcontrib>RUPERTO, N</creatorcontrib><creatorcontrib>BARCELLONA, R</creatorcontrib><creatorcontrib>GALLIZZI, R</creatorcontrib><creatorcontrib>ROSSI, F</creatorcontrib><creatorcontrib>MAGNI-MANZONI, S</creatorcontrib><creatorcontrib>LOMBARDINI, G</creatorcontrib><creatorcontrib>FILOCAMO, G</creatorcontrib><creatorcontrib>RASCHETTI, R</creatorcontrib><creatorcontrib>MARTINI, A</creatorcontrib><creatorcontrib>RAVELLI, A</creatorcontrib><creatorcontrib>GERLONI, V</creatorcontrib><creatorcontrib>SIMONINI, G</creatorcontrib><creatorcontrib>CORTIS, E</creatorcontrib><creatorcontrib>LEPORE, L</creatorcontrib><creatorcontrib>ALPIGIANI, M. G</creatorcontrib><creatorcontrib>ZULIAN, F</creatorcontrib><creatorcontrib>CORONA, F</creatorcontrib><creatorcontrib>ALESSIO, M</creatorcontrib><creatorcontrib>Italian Pediatric Rheumatology Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NIELSEN, S</au><au>RUPERTO, N</au><au>BARCELLONA, R</au><au>GALLIZZI, R</au><au>ROSSI, F</au><au>MAGNI-MANZONI, S</au><au>LOMBARDINI, G</au><au>FILOCAMO, G</au><au>RASCHETTI, R</au><au>MARTINI, A</au><au>RAVELLI, A</au><au>GERLONI, V</au><au>SIMONINI, G</au><au>CORTIS, E</au><au>LEPORE, L</au><au>ALPIGIANI, M. G</au><au>ZULIAN, F</au><au>CORONA, F</au><au>ALESSIO, M</au><aucorp>Italian Pediatric Rheumatology Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>26</volume><issue>4</issue><spage>688</spage><epage>692</epage><pages>688-692</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>To investigate the rate of radiographic progression, as measured with the carpo-metacarpal ratio (Poznanski score), during etanercept (ETN) therapy in children with polyarticular juvenile idiopathic arthritis (JIA).
Patients included in the Italian ETN registry who had a standard radiograph of both hands and wrists in the posteroanterior view made at start of treatment and after 1 year were included in the study. The clinical response was assessed by means of the ACR Pediatric definition of improvement. Radiographic progression was determined by calculating the change in the Poznanski score between the baseline and the 1-year radiographs.
A total of 40 patients were studied. The frequency of ACR pediatric 30, 50, and 70 response at 1 year was 77%, 72%, and 50%, respectively. The median change in the Poznanski score between baseline and 1 year was + 0.3 units, meaning that, on average, patients experienced improvement in radiographic progression.
Our pilot study provides evidence that ETN is potentially capable of reducing the progression of radiographic joint damage in JIA. This finding deserves confirmation in a controlled trial.</abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>18799107</pmid><tpages>5</tpages></addata></record> |
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| subjects | Arthritis, Juvenile - diagnostic imaging Arthritis, Juvenile - drug therapy Biological and medical sciences Child Child, Preschool Diseases of the osteoarticular system Etanercept Female Humans Immunoglobulin G - therapeutic use Immunomodulators Immunosuppressive Agents - therapeutic use Inflammatory joint diseases Male Medical sciences Metacarpal Bones - diagnostic imaging Pharmacology. Drug treatments Radiography Receptors, Tumor Necrosis Factor - therapeutic use Registries Retrospective Studies Severity of Illness Index Treatment Outcome |
| title | Preliminary evidence that etanercept may reduce radiographic progression in juvenile idiopathic arthritis |
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