Specific skin manifestations in CD56 positive acute myeloid leukemia
We found 16 CD56+ cases (29.6%) among 54 acute myeloid leukemia (AML) patients; they showed significantly Frequent cutaneous involvement compared to CD56‐ cases (43.8% vs.15.8%, p
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| Veröffentlicht in: | Journal of cutaneous pathology 1999-01, Vol.26 (1), p.1-5 |
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| container_title | Journal of cutaneous pathology |
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| creator | Kuwabara, Hiroko Nagai, Masami Yamaoka, Genji Ohnishi, Hiroaki Kawakami, Kimihiro |
| description | We found 16 CD56+ cases (29.6%) among 54 acute myeloid leukemia (AML) patients; they showed significantly Frequent cutaneous involvement compared to CD56‐ cases (43.8% vs.15.8%, p |
| doi_str_mv | 10.1111/j.1600-0560.1999.tb01782.x |
| format | Article |
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Four of the CD56+ AML cases with specific skin manifestations were reviewed histologieally. In all cases, cutaneous leukemic cells were seen in the dermis and subcutaneous tissue with accentuation around the adnexa/nerve, but sparing the epidermis. In addition, angiocentric/angiodestructive and prominent cohesive tumor cell growth were seen in two rases, respectively. These findings suggest that the expression of CD56 may often be associated with the cutaneous involvement in AML, and that the above histological findings should remind us of the possibility of specific skin manifestations in CD56+ AML.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/j.1600-0560.1999.tb01782.x</identifier><identifier>PMID: 10189238</identifier><identifier>CODEN: JCUPBN</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; Adult ; Biological and medical sciences ; CD56 Antigen - analysis ; Female ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; Immunophenotyping ; Leukemia, Myeloid - metabolism ; Leukemia, Myeloid - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Skin - chemistry ; Skin - pathology ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology</subject><ispartof>Journal of cutaneous pathology, 1999-01, Vol.26 (1), p.1-5</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5011-aaa40a8b8fac00f4c54ee668f26e39139e8bcecaf920536c514331364369301c3</citedby><cites>FETCH-LOGICAL-c5011-aaa40a8b8fac00f4c54ee668f26e39139e8bcecaf920536c514331364369301c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0560.1999.tb01782.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0560.1999.tb01782.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1643077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10189238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuwabara, Hiroko</creatorcontrib><creatorcontrib>Nagai, Masami</creatorcontrib><creatorcontrib>Yamaoka, Genji</creatorcontrib><creatorcontrib>Ohnishi, Hiroaki</creatorcontrib><creatorcontrib>Kawakami, Kimihiro</creatorcontrib><title>Specific skin manifestations in CD56 positive acute myeloid leukemia</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>We found 16 CD56+ cases (29.6%) among 54 acute myeloid leukemia (AML) patients; they showed significantly Frequent cutaneous involvement compared to CD56‐ cases (43.8% vs.15.8%, p<0.05). Four of the CD56+ AML cases with specific skin manifestations were reviewed histologieally. In all cases, cutaneous leukemic cells were seen in the dermis and subcutaneous tissue with accentuation around the adnexa/nerve, but sparing the epidermis. In addition, angiocentric/angiodestructive and prominent cohesive tumor cell growth were seen in two rases, respectively. These findings suggest that the expression of CD56 may often be associated with the cutaneous involvement in AML, and that the above histological findings should remind us of the possibility of specific skin manifestations in CD56+ AML.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>CD56 Antigen - analysis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunophenotyping</subject><subject>Leukemia, Myeloid - metabolism</subject><subject>Leukemia, Myeloid - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Skin - chemistry</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1vEzEQhi1ERUPhL6AVQtw2Ha_XXhtxQSktSFGhKlWP1sQdS072I13vQvLvcbRR4VpfLI2f1_PqYew9hzlP53w95wogB6nSwBgzH1bAK13Mdy_Y7OnpJZuBAJEro6tT9jrGNQBXWslX7JQD16YQesYubrfkgg8ui5vQZg22wVMccAhdG7M0WVxIlW27GIbwmzJ040BZs6e6Cw9ZTeOGmoBv2InHOtLb433G7i6__lp8y5c_rr4vvixzJ4HzHBFLQL3SHh2AL50siZTSvlAkDBeG9MqRQ28KkEI5yUshuFClUEYAd-KMfZz-3fbd45hq2iZER3WNLXVjtMrIqlCFTuCnCXR9F2NP3m770GC_txzswaFd24MoexBlDw7t0aHdpfC745Zx1dDDf9FJWgI-HAGMDmvfY-tC_MelwlBVCfs8YX9CTftnNLCLu588xfMpHuJAu6c49hurKlFJe399Ze9vzM2tXl7aUvwFbiib6Q</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Kuwabara, Hiroko</creator><creator>Nagai, Masami</creator><creator>Yamaoka, Genji</creator><creator>Ohnishi, Hiroaki</creator><creator>Kawakami, Kimihiro</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Specific skin manifestations in CD56 positive acute myeloid leukemia</title><author>Kuwabara, Hiroko ; Nagai, Masami ; Yamaoka, Genji ; Ohnishi, Hiroaki ; Kawakami, Kimihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5011-aaa40a8b8fac00f4c54ee668f26e39139e8bcecaf920536c514331364369301c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>CD56 Antigen - analysis</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunophenotyping</topic><topic>Leukemia, Myeloid - metabolism</topic><topic>Leukemia, Myeloid - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Skin - chemistry</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuwabara, Hiroko</creatorcontrib><creatorcontrib>Nagai, Masami</creatorcontrib><creatorcontrib>Yamaoka, Genji</creatorcontrib><creatorcontrib>Ohnishi, Hiroaki</creatorcontrib><creatorcontrib>Kawakami, Kimihiro</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuwabara, Hiroko</au><au>Nagai, Masami</au><au>Yamaoka, Genji</au><au>Ohnishi, Hiroaki</au><au>Kawakami, Kimihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific skin manifestations in CD56 positive acute myeloid leukemia</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>1999-01</date><risdate>1999</risdate><volume>26</volume><issue>1</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>We found 16 CD56+ cases (29.6%) among 54 acute myeloid leukemia (AML) patients; they showed significantly Frequent cutaneous involvement compared to CD56‐ cases (43.8% vs.15.8%, p<0.05). Four of the CD56+ AML cases with specific skin manifestations were reviewed histologieally. In all cases, cutaneous leukemic cells were seen in the dermis and subcutaneous tissue with accentuation around the adnexa/nerve, but sparing the epidermis. In addition, angiocentric/angiodestructive and prominent cohesive tumor cell growth were seen in two rases, respectively. These findings suggest that the expression of CD56 may often be associated with the cutaneous involvement in AML, and that the above histological findings should remind us of the possibility of specific skin manifestations in CD56+ AML.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10189238</pmid><doi>10.1111/j.1600-0560.1999.tb01782.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of cutaneous pathology, 1999-01, Vol.26 (1), p.1-5 |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Acute Disease Adult Biological and medical sciences CD56 Antigen - analysis Female Flow Cytometry Hematologic and hematopoietic diseases Humans Immunohistochemistry Immunophenotyping Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Skin - chemistry Skin - pathology Skin Neoplasms - metabolism Skin Neoplasms - pathology |
| title | Specific skin manifestations in CD56 positive acute myeloid leukemia |
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