Circulating Postinjury Neutrophils Are Primed for the Release of Proinflammatory Cytokines

BACKGROUNDPostinjury neutrophil (PMN) priming identifies the injured patient at risk for the subsequent development of multiple organ failure (MOF). PMN priming has previously been shown to cause enhanced release of proteases and superoxide. PMNs, however, are a rich source of proinflammatory cytoki...

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Veröffentlicht in:	The Journal of Trauma: Injury, Infection, and Critical Care Infection, and Critical Care, 1999-01, Vol.46 (1), p.42-48
Hauptverfasser:	Zallen, Garret, Moore, Ernest E., Johnson, Jeffrey L., Tamura, Douglas Y., Aiboshi, Junichi, Biffl, Walter L., Silliman, Christopher C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Case-Control Studies Cytokines - metabolism Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine Female Humans Injury Severity Score Intensive care medicine Interleukin-1 - metabolism Interleukin-8 - metabolism Male Medical sciences Multiple Organ Failure - immunology Neutrophils - metabolism Tumor Necrosis Factor-alpha - metabolism Wounds and Injuries - immunology
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