Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function
OBJECTIVE: To examine the association between muscular function and the serum concentrations of 25‐hydroxyvitamin D (calcidiol) and 1,25‐dihydroxyvitamin D (calcitriol). DESIGN: A randomized population survey. Baseline measurements of serum calcidiol and calcitriol concentrations and assessment of m...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 1999-02, Vol.47 (2), p.220-226 |
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| creator | Mowé, Morten Haug, Egil Bøhmer, Thomas |
| description | OBJECTIVE: To examine the association between muscular function and the serum concentrations of 25‐hydroxyvitamin D (calcidiol) and 1,25‐dihydroxyvitamin D (calcitriol).
DESIGN: A randomized population survey. Baseline measurements of serum calcidiol and calcitriol concentrations and assessment of muscular function (hand grip strength, ability to climb stairs, outdoor activity, and fall occurrence).
SETTING: The Medical department, Aker University Hospital, Oslo, and subjects' homes.
PARTICIPANTS: Two hundred forty‐six recently hospitalized older patients and 103 randomly selected older people living at home.
MEASUREMENTS: Serum concentration of calcidiol and calcitriol in relation to muscle function.
MAIN RESULTS: Reduced muscle function was associated with low calcidiol levels. In both the hospital group and the home group, calcidiol concentrations correlated positively to arm muscle strength (r = .22, P < .001, r = .37, P < .001), ability to climb stairs (r = .16, P < .05; r = ‐.42, P = |
| doi_str_mv | 10.1111/j.1532-5415.1999.tb04581.x |
| format | Article |
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DESIGN: A randomized population survey. Baseline measurements of serum calcidiol and calcitriol concentrations and assessment of muscular function (hand grip strength, ability to climb stairs, outdoor activity, and fall occurrence).
SETTING: The Medical department, Aker University Hospital, Oslo, and subjects' homes.
PARTICIPANTS: Two hundred forty‐six recently hospitalized older patients and 103 randomly selected older people living at home.
MEASUREMENTS: Serum concentration of calcidiol and calcitriol in relation to muscle function.
MAIN RESULTS: Reduced muscle function was associated with low calcidiol levels. In both the hospital group and the home group, calcidiol concentrations correlated positively to arm muscle strength (r = .22, P < .001, r = .37, P < .001), ability to climb stairs (r = .16, P < .05; r = ‐.42, P = <.001), physical activity (r = ‐.27, P < .001; r = ‐.31, P < .001), and the absence of fall occurrences (r = ‐.27, P < .001; r = ‐.31, P = .004). Calcitriol showed an association with physical activity in the hospital group (r = ‐.19, P < .05), and with fall last month in the home group (r = ‐.22, P < .05).
CONCLUSIONS: Older people with reduced muscle function often had reduced levels of calcidiol serum concentration. Low levels of calcidiol were not associated with signs of general undernutrition, such as low body mass, or with reduced arm‐muscle circumference or triceps skinfold thickness. This finding may suggest a physiological role for calcidiol in muscle function. Reduced muscle strength increased disability in our older subjects, which may be improved by vitamin D supplementation in vitamin D‐deficient subjects. J Am Geriatr Soc 47:220–226, 1999.]]></description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.1999.tb04581.x</identifier><identifier>PMID: 9988294</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Activities of Daily Living - classification ; Aged ; Aged, 80 and over ; Biological and medical sciences ; calcidiol ; Calcifediol - blood ; calcitriol ; Calcitriol - blood ; Disability Evaluation ; Elderly people ; Factors ; Female ; Frail Elderly ; Functioning ; Geriatric Assessment ; Hand Strength - physiology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; muscle strength ; Muscles ; Muscular Atrophy - blood ; muscular function ; Muscular system ; Older people ; Osteoarticular system. Muscles ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Reference Values ; Vitamin D ; Vitamin D deficiency</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 1999-02, Vol.47 (2), p.220-226</ispartof><rights>1999 The American Geriatrics Society</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Feb 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4951-e166e407bd362bcf636178b22a0a1ed42e5a44e323aa713a4a0fe5180463201e3</citedby><cites>FETCH-LOGICAL-c4951-e166e407bd362bcf636178b22a0a1ed42e5a44e323aa713a4a0fe5180463201e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.1999.tb04581.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.1999.tb04581.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,30977,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1692254$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9988294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mowé, Morten</creatorcontrib><creatorcontrib>Haug, Egil</creatorcontrib><creatorcontrib>Bøhmer, Thomas</creatorcontrib><title>Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description><![CDATA[OBJECTIVE: To examine the association between muscular function and the serum concentrations of 25‐hydroxyvitamin D (calcidiol) and 1,25‐dihydroxyvitamin D (calcitriol).
DESIGN: A randomized population survey. Baseline measurements of serum calcidiol and calcitriol concentrations and assessment of muscular function (hand grip strength, ability to climb stairs, outdoor activity, and fall occurrence).
SETTING: The Medical department, Aker University Hospital, Oslo, and subjects' homes.
PARTICIPANTS: Two hundred forty‐six recently hospitalized older patients and 103 randomly selected older people living at home.
MEASUREMENTS: Serum concentration of calcidiol and calcitriol in relation to muscle function.
MAIN RESULTS: Reduced muscle function was associated with low calcidiol levels. In both the hospital group and the home group, calcidiol concentrations correlated positively to arm muscle strength (r = .22, P < .001, r = .37, P < .001), ability to climb stairs (r = .16, P < .05; r = ‐.42, P = <.001), physical activity (r = ‐.27, P < .001; r = ‐.31, P < .001), and the absence of fall occurrences (r = ‐.27, P < .001; r = ‐.31, P = .004). Calcitriol showed an association with physical activity in the hospital group (r = ‐.19, P < .05), and with fall last month in the home group (r = ‐.22, P < .05).
CONCLUSIONS: Older people with reduced muscle function often had reduced levels of calcidiol serum concentration. Low levels of calcidiol were not associated with signs of general undernutrition, such as low body mass, or with reduced arm‐muscle circumference or triceps skinfold thickness. This finding may suggest a physiological role for calcidiol in muscle function. Reduced muscle strength increased disability in our older subjects, which may be improved by vitamin D supplementation in vitamin D‐deficient subjects. J Am Geriatr Soc 47:220–226, 1999.]]></description><subject>Activities of Daily Living - classification</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>calcidiol</subject><subject>Calcifediol - blood</subject><subject>calcitriol</subject><subject>Calcitriol - blood</subject><subject>Disability Evaluation</subject><subject>Elderly people</subject><subject>Factors</subject><subject>Female</subject><subject>Frail Elderly</subject><subject>Functioning</subject><subject>Geriatric Assessment</subject><subject>Hand Strength - physiology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>muscle strength</subject><subject>Muscles</subject><subject>Muscular Atrophy - blood</subject><subject>muscular function</subject><subject>Muscular system</subject><subject>Older people</subject><subject>Osteoarticular system. Muscles</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Reference Values</subject><subject>Vitamin D</subject><subject>Vitamin D deficiency</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqVkV2L1DAUhoMo67j6E4SwiHet-U7jjSyDO36MruzoehnSNMWMmXZNGmb239syZQRvxFwkB97nvCfJC8AFRiUe16ttiTklBWeYl1gpVQ41YrzC5eEBWJykh2CBECJFJTB7DJ6ktEUIE1RVZ-BMqaoiii3Al3W_hxsX8w4uTbC-8X2Ay76zrhuiGXzfQd_B69C4CC-bHIYE9374AW9ck61r4KecbA4mwqvc2Ql_Ch61JiT3bD7Pwbert1-X74r19er98nJdWKY4LhwWwjEk64YKUttWUIFlVRNikMGuYcRxw5ijhBojMTXMoNZxXCEmKEHY0XPw8uh7F_tf2aVB73yyLgTTuT4nLRQXatz-CXIp8fhFE3jxF7jtc-zGR2iCEZWSETlCr4-QjX1K0bX6LvqdifcaIz2Fo7d6SkBPCegpHD2How9j8_N5Qq53rjm1zmmM-otZN8ma0EbTWZ_-TBCKED5hb47Y3gd3_x8X0B9Wm6kaHYqjg0-DO5wcTPyphaSS6--fV3otN9WN_Hirb-lvk6e5TQ</recordid><startdate>199902</startdate><enddate>199902</enddate><creator>Mowé, Morten</creator><creator>Haug, Egil</creator><creator>Bøhmer, Thomas</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>199902</creationdate><title>Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function</title><author>Mowé, Morten ; Haug, Egil ; Bøhmer, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4951-e166e407bd362bcf636178b22a0a1ed42e5a44e323aa713a4a0fe5180463201e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Activities of Daily Living - classification</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>calcidiol</topic><topic>Calcifediol - blood</topic><topic>calcitriol</topic><topic>Calcitriol - blood</topic><topic>Disability Evaluation</topic><topic>Elderly people</topic><topic>Factors</topic><topic>Female</topic><topic>Frail Elderly</topic><topic>Functioning</topic><topic>Geriatric Assessment</topic><topic>Hand Strength - physiology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>muscle strength</topic><topic>Muscles</topic><topic>Muscular Atrophy - blood</topic><topic>muscular function</topic><topic>Muscular system</topic><topic>Older people</topic><topic>Osteoarticular system. Muscles</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Reference Values</topic><topic>Vitamin D</topic><topic>Vitamin D deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mowé, Morten</creatorcontrib><creatorcontrib>Haug, Egil</creatorcontrib><creatorcontrib>Bøhmer, Thomas</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mowé, Morten</au><au>Haug, Egil</au><au>Bøhmer, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>1999-02</date><risdate>1999</risdate><volume>47</volume><issue>2</issue><spage>220</spage><epage>226</epage><pages>220-226</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract><![CDATA[OBJECTIVE: To examine the association between muscular function and the serum concentrations of 25‐hydroxyvitamin D (calcidiol) and 1,25‐dihydroxyvitamin D (calcitriol).
DESIGN: A randomized population survey. Baseline measurements of serum calcidiol and calcitriol concentrations and assessment of muscular function (hand grip strength, ability to climb stairs, outdoor activity, and fall occurrence).
SETTING: The Medical department, Aker University Hospital, Oslo, and subjects' homes.
PARTICIPANTS: Two hundred forty‐six recently hospitalized older patients and 103 randomly selected older people living at home.
MEASUREMENTS: Serum concentration of calcidiol and calcitriol in relation to muscle function.
MAIN RESULTS: Reduced muscle function was associated with low calcidiol levels. In both the hospital group and the home group, calcidiol concentrations correlated positively to arm muscle strength (r = .22, P < .001, r = .37, P < .001), ability to climb stairs (r = .16, P < .05; r = ‐.42, P = <.001), physical activity (r = ‐.27, P < .001; r = ‐.31, P < .001), and the absence of fall occurrences (r = ‐.27, P < .001; r = ‐.31, P = .004). Calcitriol showed an association with physical activity in the hospital group (r = ‐.19, P < .05), and with fall last month in the home group (r = ‐.22, P < .05).
CONCLUSIONS: Older people with reduced muscle function often had reduced levels of calcidiol serum concentration. Low levels of calcidiol were not associated with signs of general undernutrition, such as low body mass, or with reduced arm‐muscle circumference or triceps skinfold thickness. This finding may suggest a physiological role for calcidiol in muscle function. Reduced muscle strength increased disability in our older subjects, which may be improved by vitamin D supplementation in vitamin D‐deficient subjects. J Am Geriatr Soc 47:220–226, 1999.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9988294</pmid><doi>10.1111/j.1532-5415.1999.tb04581.x</doi><tpages>7</tpages></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Activities of Daily Living - classification Aged Aged, 80 and over Biological and medical sciences calcidiol Calcifediol - blood calcitriol Calcitriol - blood Disability Evaluation Elderly people Factors Female Frail Elderly Functioning Geriatric Assessment Hand Strength - physiology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences muscle strength Muscles Muscular Atrophy - blood muscular function Muscular system Older people Osteoarticular system. Muscles Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reference Values Vitamin D Vitamin D deficiency |
| title | Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function |
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