Thymic alterations in Plasmodium berghei-infected mice
The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious...
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| Veröffentlicht in: | Cellular immunology 2008-01, Vol.253 (1), p.1-4 |
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| container_title | Cellular immunology |
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| creator | Andrade, C.F. Gameiro, J. Nagib, P.R.A. Carvalho, B.O. Talaisys, R.L. Costa, F.T.M. Verinaud, L. |
| description | The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we investigated if thymus is also a target organ during experimental malaria infection by analyzing the presence of parasites inside the organ and histological alterations in thymuses from
Plasmodium berghei NK65-infected BALB/c. After 14 days of infection, parasites were found inside the thymus that presented a profound atrophy with total loss of its architecture. We propose that the presence of parasites in the thymus induces histological modifications that alter the microenvironment, impairing by consequence the successful T cell development. Additional studies are currently being developed in our laboratory to verify if such thymic alterations can influence the systemic immune response to the parasite. |
| doi_str_mv | 10.1016/j.cellimm.2008.06.001 |
| format | Article |
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Plasmodium berghei NK65-infected BALB/c. After 14 days of infection, parasites were found inside the thymus that presented a profound atrophy with total loss of its architecture. We propose that the presence of parasites in the thymus induces histological modifications that alter the microenvironment, impairing by consequence the successful T cell development. Additional studies are currently being developed in our laboratory to verify if such thymic alterations can influence the systemic immune response to the parasite.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/j.cellimm.2008.06.001</identifier><identifier>PMID: 18635160</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Malaria - immunology ; Malaria - parasitology ; Malaria - pathology ; Male ; Mice ; Mice, Inbred BALB C ; Plasmodium berghei ; Plasmodium berghei - genetics ; Plasmodium berghei - immunology ; T-cell generation ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes - immunology ; T-Lymphocytes - physiology ; Thymic atrophy ; Thymus ; Thymus Gland - immunology ; Thymus Gland - parasitology ; Thymus Gland - pathology</subject><ispartof>Cellular immunology, 2008-01, Vol.253 (1), p.1-4</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-8df330c66035706b80b88fb2a687cc27961cea99810223b5fbceeb30171672a93</citedby><cites>FETCH-LOGICAL-c394t-8df330c66035706b80b88fb2a687cc27961cea99810223b5fbceeb30171672a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000887490800107X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18635160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrade, C.F.</creatorcontrib><creatorcontrib>Gameiro, J.</creatorcontrib><creatorcontrib>Nagib, P.R.A.</creatorcontrib><creatorcontrib>Carvalho, B.O.</creatorcontrib><creatorcontrib>Talaisys, R.L.</creatorcontrib><creatorcontrib>Costa, F.T.M.</creatorcontrib><creatorcontrib>Verinaud, L.</creatorcontrib><title>Thymic alterations in Plasmodium berghei-infected mice</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we investigated if thymus is also a target organ during experimental malaria infection by analyzing the presence of parasites inside the organ and histological alterations in thymuses from
Plasmodium berghei NK65-infected BALB/c. After 14 days of infection, parasites were found inside the thymus that presented a profound atrophy with total loss of its architecture. We propose that the presence of parasites in the thymus induces histological modifications that alter the microenvironment, impairing by consequence the successful T cell development. Additional studies are currently being developed in our laboratory to verify if such thymic alterations can influence the systemic immune response to the parasite.</description><subject>Animals</subject><subject>Malaria - immunology</subject><subject>Malaria - parasitology</subject><subject>Malaria - pathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Plasmodium berghei</subject><subject>Plasmodium berghei - genetics</subject><subject>Plasmodium berghei - immunology</subject><subject>T-cell generation</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - physiology</subject><subject>Thymic atrophy</subject><subject>Thymus</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - parasitology</subject><subject>Thymus Gland - pathology</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BFBW7BJm7MaxVwghXhISLMracpwJdZUH2ClS_x5XrcSS1Szm3Lmaw9glQoGA8mZVOOo63_cFB1AFyAIAD9gMQUPOUYpDNoO0yVU11yfsNMZVAnCu4ZidoJKiRAkzJhfLTe9dZruJgp38OMTMD9l7Z2M_Nn7dZzWFzyX53A8tuYmaLOF0zo5a20W62M8z9vH4sLh_zl_fnl7u715zJ_R8ylXTCgFOShBlBbJWUCvV1txKVTnHKy3RkdVaIXAu6rKtHVEtACuUFbdanLHr3d2vMH6vKU6m93H7uB1oXEcjdSm14PAviLoqUSBPYLkDXRhjDNSar-B7GzYGwWzNmpXZmzVbswakSeJS7mpfsK57av5Se5UJuN0BlHz8eAomOk-Do8aHJM40o_-n4hedgYsb</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Andrade, C.F.</creator><creator>Gameiro, J.</creator><creator>Nagib, P.R.A.</creator><creator>Carvalho, B.O.</creator><creator>Talaisys, R.L.</creator><creator>Costa, F.T.M.</creator><creator>Verinaud, L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Thymic alterations in Plasmodium berghei-infected mice</title><author>Andrade, C.F. ; Gameiro, J. ; Nagib, P.R.A. ; Carvalho, B.O. ; Talaisys, R.L. ; Costa, F.T.M. ; Verinaud, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-8df330c66035706b80b88fb2a687cc27961cea99810223b5fbceeb30171672a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Malaria - immunology</topic><topic>Malaria - parasitology</topic><topic>Malaria - pathology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Plasmodium berghei</topic><topic>Plasmodium berghei - genetics</topic><topic>Plasmodium berghei - immunology</topic><topic>T-cell generation</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - physiology</topic><topic>Thymic atrophy</topic><topic>Thymus</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - parasitology</topic><topic>Thymus Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrade, C.F.</creatorcontrib><creatorcontrib>Gameiro, J.</creatorcontrib><creatorcontrib>Nagib, P.R.A.</creatorcontrib><creatorcontrib>Carvalho, B.O.</creatorcontrib><creatorcontrib>Talaisys, R.L.</creatorcontrib><creatorcontrib>Costa, F.T.M.</creatorcontrib><creatorcontrib>Verinaud, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrade, C.F.</au><au>Gameiro, J.</au><au>Nagib, P.R.A.</au><au>Carvalho, B.O.</au><au>Talaisys, R.L.</au><au>Costa, F.T.M.</au><au>Verinaud, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thymic alterations in Plasmodium berghei-infected mice</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>253</volume><issue>1</issue><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we investigated if thymus is also a target organ during experimental malaria infection by analyzing the presence of parasites inside the organ and histological alterations in thymuses from
Plasmodium berghei NK65-infected BALB/c. After 14 days of infection, parasites were found inside the thymus that presented a profound atrophy with total loss of its architecture. We propose that the presence of parasites in the thymus induces histological modifications that alter the microenvironment, impairing by consequence the successful T cell development. Additional studies are currently being developed in our laboratory to verify if such thymic alterations can influence the systemic immune response to the parasite.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>18635160</pmid><doi>10.1016/j.cellimm.2008.06.001</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| subjects | Animals Malaria - immunology Malaria - parasitology Malaria - pathology Male Mice Mice, Inbred BALB C Plasmodium berghei Plasmodium berghei - genetics Plasmodium berghei - immunology T-cell generation T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology T-Lymphocytes - physiology Thymic atrophy Thymus Thymus Gland - immunology Thymus Gland - parasitology Thymus Gland - pathology |
| title | Thymic alterations in Plasmodium berghei-infected mice |
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