F4 ‐ Isoprostanes as Specific Marker of Docosahexaenoic Acid Peroxidation in Alzheimer's Disease

: F2‐isoprostanes are prostaglandin‐like compounds derived from free radical‐catalysed peroxidation of arachidonic acid. Peroxidation of eicosapentaenoic acid produces F3‐isoprostanes, whereas peroxidation of docosahexaenoic acid would give F4‐isoprostanes. This study demonstrates the presence of es...

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Veröffentlicht in:	Journal of neurochemistry 1999-02, Vol.72 (2), p.734-740
Hauptverfasser:	Nourooz‐Zadeh, Jaffar, Liu, Edwin H. C., Yhlen, B., Änggåard, Erik E., Halliwell, Barry
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Arachidonic acid Arachidonic Acid - analysis Arachidonic Acid - chemistry Biological and medical sciences Biomarkers Brain Chemistry Cerebral Cortex - chemistry Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Docosahexaenoic acid Docosahexaenoic Acids - analysis Docosahexaenoic Acids - chemistry Eicosapentaenoic Acid - analysis Eicosapentaenoic Acid - chemistry Esters - analysis Gas Chromatography-Mass Spectrometry Humans Isoprostanes Lipid peroxidation Lipid Peroxidation - physiology Lipids - analysis Medical sciences Neurology
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