GRC5 and NMD3 function in translational control of gene expression and interact genetically
The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expr...
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| Veröffentlicht in: | Current genetics 1999-01, Vol.34 (6), p.419-429 |
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| container_issue | 6 |
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| container_title | Current genetics |
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| creator | Karl, T Onder, K Kodzius, R Pichova, A Wimmer, H Thur, A Hundsberger, H Loffler, M Klade, T Beyer, A |
| description | The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1ts allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p. |
| doi_str_mv | 10.1007/s002940050416 |
| format | Article |
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GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1ts allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p.</description><identifier>ISSN: 0172-8083</identifier><identifier>EISSN: 1432-0983</identifier><identifier>DOI: 10.1007/s002940050416</identifier><identifier>PMID: 9933353</identifier><language>eng</language><publisher>United States</publisher><subject>actin ; Alleles ; Amino Acid Sequence ; amino acid sequences ; Animals ; Base Sequence ; cytochemistry ; DNA Primers - genetics ; genbank/u31376 ; genbank/x78887 ; gene expression ; Gene Expression Regulation ; gene interaction ; Genes, Fungal ; genetic regulation ; grc5 gene ; Humans ; Molecular Sequence Data ; mutants ; Mutation ; nmd3 gene ; nuclei ; nucleotide sequences ; Phenotype ; Protein Biosynthesis ; proteins ; revertants ; ribosomal protein l10 ; Ribosomal Proteins - genetics ; ribosomes ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Sequence Homology, Amino Acid ; structural genes ; suppressor mutations ; translation ; Wilms Tumor - genetics</subject><ispartof>Current genetics, 1999-01, Vol.34 (6), p.419-429</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-5efb9fc2b15db2f3c30f728e986240346cb32a9a18f9d4a302fa7658657ac61a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9933353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karl, T</creatorcontrib><creatorcontrib>Onder, K</creatorcontrib><creatorcontrib>Kodzius, R</creatorcontrib><creatorcontrib>Pichova, A</creatorcontrib><creatorcontrib>Wimmer, H</creatorcontrib><creatorcontrib>Thur, A</creatorcontrib><creatorcontrib>Hundsberger, H</creatorcontrib><creatorcontrib>Loffler, M</creatorcontrib><creatorcontrib>Klade, T</creatorcontrib><creatorcontrib>Beyer, A</creatorcontrib><title>GRC5 and NMD3 function in translational control of gene expression and interact genetically</title><title>Current genetics</title><addtitle>Curr Genet</addtitle><description>The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1ts allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p.</description><subject>actin</subject><subject>Alleles</subject><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>cytochemistry</subject><subject>DNA Primers - genetics</subject><subject>genbank/u31376</subject><subject>genbank/x78887</subject><subject>gene expression</subject><subject>Gene Expression Regulation</subject><subject>gene interaction</subject><subject>Genes, Fungal</subject><subject>genetic regulation</subject><subject>grc5 gene</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>mutants</subject><subject>Mutation</subject><subject>nmd3 gene</subject><subject>nuclei</subject><subject>nucleotide sequences</subject><subject>Phenotype</subject><subject>Protein Biosynthesis</subject><subject>proteins</subject><subject>revertants</subject><subject>ribosomal protein l10</subject><subject>Ribosomal Proteins - genetics</subject><subject>ribosomes</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Sequence Homology, Amino Acid</subject><subject>structural genes</subject><subject>suppressor mutations</subject><subject>translation</subject><subject>Wilms Tumor - genetics</subject><issn>0172-8083</issn><issn>1432-0983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPIzEQRi0ECgGuvPKEK7rlxp712i5RgIDE3UlAqitWs46NFm28wd5I8O9JSIRERTUafW8-aR5jPwWcCwD9OwNIWwIoKEW1x8aiRFmANbjPxiC0LAwYPGRHOT8DCGmsHrGRtYiocMz-T-8nilOc879_LpGHVXRD20feRj4kirmjzUodd30cUt_xPvAnHz33r8vkc96wm-s2Dj6RGz7CoXXUdW8n7CBQl_2P3Txms-urx8lNcfdveju5uCscljgUyofGBicboeaNDOgQgpbGW1PJErCsXIOSLAkT7LwkBBlIV8pUSpOrBOExO9v2LlP_svJ5qBdtdr7rKPp-levKqspIDd-CQiOUCu0aLLagS33OyYd6mdoFpbdaQL2xXn-xvuZ_7YpXzcLPP-md5nV-us0D9TU9pTbXswcJYv2LsUpog-_kToU0</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Karl, T</creator><creator>Onder, K</creator><creator>Kodzius, R</creator><creator>Pichova, A</creator><creator>Wimmer, H</creator><creator>Thur, A</creator><creator>Hundsberger, H</creator><creator>Loffler, M</creator><creator>Klade, T</creator><creator>Beyer, A</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>GRC5 and NMD3 function in translational control of gene expression and interact genetically</title><author>Karl, T ; 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| identifier | ISSN: 0172-8083 |
| ispartof | Current genetics, 1999-01, Vol.34 (6), p.419-429 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | actin Alleles Amino Acid Sequence amino acid sequences Animals Base Sequence cytochemistry DNA Primers - genetics genbank/u31376 genbank/x78887 gene expression Gene Expression Regulation gene interaction Genes, Fungal genetic regulation grc5 gene Humans Molecular Sequence Data mutants Mutation nmd3 gene nuclei nucleotide sequences Phenotype Protein Biosynthesis proteins revertants ribosomal protein l10 Ribosomal Proteins - genetics ribosomes Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Sequence Homology, Amino Acid structural genes suppressor mutations translation Wilms Tumor - genetics |
| title | GRC5 and NMD3 function in translational control of gene expression and interact genetically |
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