Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery
Histamine, a product of mast cells, is an effective vasoconstrictor of atherosclerotic coronary arteries. Because it has been suggested that coronary spasm plays a role in acute coronary syndromes such as myocardial infarction (MI), we quantified and characterized the mast cells in the adventitia of...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1999-01, Vol.99 (3), p.361-369 |
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| creator | LAINE, P KAARTINEN, M PENTTILÄ, A PANULA, P PAAVONEN, T KOVANEN, P. T |
| description | Histamine, a product of mast cells, is an effective vasoconstrictor of atherosclerotic coronary arteries. Because it has been suggested that coronary spasm plays a role in acute coronary syndromes such as myocardial infarction (MI), we quantified and characterized the mast cells in the adventitia of infarct-related coronary arteries.
In a series of 17 autopsied MI patients, we identified the segment of the left coronary artery with ruptured plaque responsible for the infarction. More distal segments from the infarct-related coronary artery, either with nonruptured plaques or with normal intima, were also studied. Corresponding segments taken from left coronary arteries obtained from 17 patients who had died of noncardiac causes served as controls. Adventitial mast cells in the infarct-related and the control coronary arteries were identified immunohistochemically by staining for tryptase. In the infarct-related coronary arteries, we also stained for chymase and histamine. Moreover, T lymphocytes and macrophages were identified immunohistochemically and counted. In the infarct-related coronary arteries, significantly larger numbers of mast cells were present in the adventitia backing ruptured plaques (98+/-40 mast cells/mm2, mean+/-SD) than in the adventitia backing nonruptured plaques (41+/-12 mast cells/mm2; P |
| doi_str_mv | 10.1161/01.cir.99.3.361 |
| format | Article |
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In a series of 17 autopsied MI patients, we identified the segment of the left coronary artery with ruptured plaque responsible for the infarction. More distal segments from the infarct-related coronary artery, either with nonruptured plaques or with normal intima, were also studied. Corresponding segments taken from left coronary arteries obtained from 17 patients who had died of noncardiac causes served as controls. Adventitial mast cells in the infarct-related and the control coronary arteries were identified immunohistochemically by staining for tryptase. In the infarct-related coronary arteries, we also stained for chymase and histamine. Moreover, T lymphocytes and macrophages were identified immunohistochemically and counted. In the infarct-related coronary arteries, significantly larger numbers of mast cells were present in the adventitia backing ruptured plaques (98+/-40 mast cells/mm2, mean+/-SD) than in the adventitia backing nonruptured plaques (41+/-12 mast cells/mm2; P<0.001) or backing normal intima (19+/-8 mast cells/mm2; P<0.001). No such difference was found among the 3 different segments in the control coronary arteries. The majority of mast cells contained not only tryptase but also chymase. Mast cells were the only cells in the coronary adventitia that contained histamine. The proportion of adventitial mast cells that were degranulated was highest in the segments with ruptured plaques. The numbers of adventitial macrophages and T lymphocytes were also increased in the segments with plaque rupture.
In infarct-related coronary arteries, the number of degranulated mast cells in the adventitia backing ruptured plaques is increased. Histamine released from the degranulated mast cells may reach the media, where it may locally provoke coronary spasm and thus contribute to the onset of MI.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.cir.99.3.361</identifier><identifier>PMID: 9918522</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Artery Disease - immunology ; Coronary Artery Disease - pathology ; Coronary Disease - immunology ; Coronary Disease - pathology ; Coronary heart disease ; Coronary Vessels - immunology ; Endothelium, Vascular - chemistry ; Endothelium, Vascular - cytology ; Endothelium, Vascular - immunology ; Female ; Heart ; Histamine - analysis ; Histamine - physiology ; Humans ; Macrophages - immunology ; Male ; Mast Cells - chemistry ; Mast Cells - physiology ; Medical sciences ; Middle Aged ; Muscle, Smooth, Vascular - chemistry ; Muscle, Smooth, Vascular - cytology ; Muscle, Smooth, Vascular - immunology ; Myocardial Infarction - immunology ; Myocardial Infarction - pathology ; T-Lymphocytes - immunology ; Tunica Intima - chemistry ; Tunica Intima - cytology ; Tunica Intima - immunology ; Vasoconstriction - physiology</subject><ispartof>Circulation (New York, N.Y.), 1999-01, Vol.99 (3), p.361-369</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jan 26, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-af0a9f7002a51a440c26abb5d26424ba36e66fac1b53dbea90cbd943be88131d3</citedby><cites>FETCH-LOGICAL-c541t-af0a9f7002a51a440c26abb5d26424ba36e66fac1b53dbea90cbd943be88131d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1665691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9918522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LAINE, P</creatorcontrib><creatorcontrib>KAARTINEN, M</creatorcontrib><creatorcontrib>PENTTILÄ, A</creatorcontrib><creatorcontrib>PANULA, P</creatorcontrib><creatorcontrib>PAAVONEN, T</creatorcontrib><creatorcontrib>KOVANEN, P. T</creatorcontrib><title>Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Histamine, a product of mast cells, is an effective vasoconstrictor of atherosclerotic coronary arteries. Because it has been suggested that coronary spasm plays a role in acute coronary syndromes such as myocardial infarction (MI), we quantified and characterized the mast cells in the adventitia of infarct-related coronary arteries.
In a series of 17 autopsied MI patients, we identified the segment of the left coronary artery with ruptured plaque responsible for the infarction. More distal segments from the infarct-related coronary artery, either with nonruptured plaques or with normal intima, were also studied. Corresponding segments taken from left coronary arteries obtained from 17 patients who had died of noncardiac causes served as controls. Adventitial mast cells in the infarct-related and the control coronary arteries were identified immunohistochemically by staining for tryptase. In the infarct-related coronary arteries, we also stained for chymase and histamine. Moreover, T lymphocytes and macrophages were identified immunohistochemically and counted. In the infarct-related coronary arteries, significantly larger numbers of mast cells were present in the adventitia backing ruptured plaques (98+/-40 mast cells/mm2, mean+/-SD) than in the adventitia backing nonruptured plaques (41+/-12 mast cells/mm2; P<0.001) or backing normal intima (19+/-8 mast cells/mm2; P<0.001). No such difference was found among the 3 different segments in the control coronary arteries. The majority of mast cells contained not only tryptase but also chymase. Mast cells were the only cells in the coronary adventitia that contained histamine. The proportion of adventitial mast cells that were degranulated was highest in the segments with ruptured plaques. The numbers of adventitial macrophages and T lymphocytes were also increased in the segments with plaque rupture.
In infarct-related coronary arteries, the number of degranulated mast cells in the adventitia backing ruptured plaques is increased. Histamine released from the degranulated mast cells may reach the media, where it may locally provoke coronary spasm and thus contribute to the onset of MI.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Artery Disease - immunology</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Disease - immunology</subject><subject>Coronary Disease - pathology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - immunology</subject><subject>Endothelium, Vascular - chemistry</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - immunology</subject><subject>Female</subject><subject>Heart</subject><subject>Histamine - analysis</subject><subject>Histamine - physiology</subject><subject>Humans</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Mast Cells - chemistry</subject><subject>Mast Cells - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Smooth, Vascular - chemistry</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Muscle, Smooth, Vascular - immunology</subject><subject>Myocardial Infarction - immunology</subject><subject>Myocardial Infarction - pathology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tunica Intima - chemistry</subject><subject>Tunica Intima - cytology</subject><subject>Tunica Intima - immunology</subject><subject>Vasoconstriction - physiology</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtrFTEQxoNY6rH67JOwSPFtt7nvyWM5WC0UBNHnMLkspuwmNckq579veroo-DTMfL_5mAtC7wgeCJHkCpPBhjwoNbCBSfIC7YigvOeCqZdohzFW_cgofYVel3LfUslGcY7OlSJ7QekOrdelJBughhQ74-sf72O3HJOF7ALMXYgTZHtSIbqu_vTdAqV21s9zaeqpAu63jzXUAF2aTpWtrc9-hupdZ1NOEfKxg1x9Pr5BZxPMxb_d4gX6cfPp--FLf_f18-3h-q63gpPaw4RBTSPGFAQBzrGlEowRjkpOuQEmvZQTWGIEc8aDwtY4xZnx-z1hxLEL9PHZ9yGnX6svVS-hPI0O0ae1aKmEHBmRDfzwH3if1hzbbJoSKveM87FBV8-QzamU7Cf9kMPSttIE66dvaEz04fabVkoz3b7ROt5vtqtZvPvLb-dv-uWmQ7EwTxmiDeWfrZRCKsIeAduulCA</recordid><startdate>19990126</startdate><enddate>19990126</enddate><creator>LAINE, P</creator><creator>KAARTINEN, M</creator><creator>PENTTILÄ, A</creator><creator>PANULA, P</creator><creator>PAAVONEN, T</creator><creator>KOVANEN, P. T</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19990126</creationdate><title>Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery</title><author>LAINE, P ; KAARTINEN, M ; PENTTILÄ, A ; PANULA, P ; PAAVONEN, T ; KOVANEN, P. 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Vascular system</topic><topic>Coronary Artery Disease - immunology</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Disease - immunology</topic><topic>Coronary Disease - pathology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - immunology</topic><topic>Endothelium, Vascular - chemistry</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - immunology</topic><topic>Female</topic><topic>Heart</topic><topic>Histamine - analysis</topic><topic>Histamine - physiology</topic><topic>Humans</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Mast Cells - chemistry</topic><topic>Mast Cells - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Smooth, Vascular - chemistry</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Muscle, Smooth, Vascular - immunology</topic><topic>Myocardial Infarction - immunology</topic><topic>Myocardial Infarction - pathology</topic><topic>T-Lymphocytes - immunology</topic><topic>Tunica Intima - chemistry</topic><topic>Tunica Intima - cytology</topic><topic>Tunica Intima - immunology</topic><topic>Vasoconstriction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LAINE, P</creatorcontrib><creatorcontrib>KAARTINEN, M</creatorcontrib><creatorcontrib>PENTTILÄ, A</creatorcontrib><creatorcontrib>PANULA, P</creatorcontrib><creatorcontrib>PAAVONEN, T</creatorcontrib><creatorcontrib>KOVANEN, P. T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LAINE, P</au><au>KAARTINEN, M</au><au>PENTTILÄ, A</au><au>PANULA, P</au><au>PAAVONEN, T</au><au>KOVANEN, P. T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1999-01-26</date><risdate>1999</risdate><volume>99</volume><issue>3</issue><spage>361</spage><epage>369</epage><pages>361-369</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Histamine, a product of mast cells, is an effective vasoconstrictor of atherosclerotic coronary arteries. Because it has been suggested that coronary spasm plays a role in acute coronary syndromes such as myocardial infarction (MI), we quantified and characterized the mast cells in the adventitia of infarct-related coronary arteries.
In a series of 17 autopsied MI patients, we identified the segment of the left coronary artery with ruptured plaque responsible for the infarction. More distal segments from the infarct-related coronary artery, either with nonruptured plaques or with normal intima, were also studied. Corresponding segments taken from left coronary arteries obtained from 17 patients who had died of noncardiac causes served as controls. Adventitial mast cells in the infarct-related and the control coronary arteries were identified immunohistochemically by staining for tryptase. In the infarct-related coronary arteries, we also stained for chymase and histamine. Moreover, T lymphocytes and macrophages were identified immunohistochemically and counted. In the infarct-related coronary arteries, significantly larger numbers of mast cells were present in the adventitia backing ruptured plaques (98+/-40 mast cells/mm2, mean+/-SD) than in the adventitia backing nonruptured plaques (41+/-12 mast cells/mm2; P<0.001) or backing normal intima (19+/-8 mast cells/mm2; P<0.001). No such difference was found among the 3 different segments in the control coronary arteries. The majority of mast cells contained not only tryptase but also chymase. Mast cells were the only cells in the coronary adventitia that contained histamine. The proportion of adventitial mast cells that were degranulated was highest in the segments with ruptured plaques. The numbers of adventitial macrophages and T lymphocytes were also increased in the segments with plaque rupture.
In infarct-related coronary arteries, the number of degranulated mast cells in the adventitia backing ruptured plaques is increased. Histamine released from the degranulated mast cells may reach the media, where it may locally provoke coronary spasm and thus contribute to the onset of MI.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9918522</pmid><doi>10.1161/01.cir.99.3.361</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 1999-01, Vol.99 (3), p.361-369 |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Biological and medical sciences Cardiology. Vascular system Coronary Artery Disease - immunology Coronary Artery Disease - pathology Coronary Disease - immunology Coronary Disease - pathology Coronary heart disease Coronary Vessels - immunology Endothelium, Vascular - chemistry Endothelium, Vascular - cytology Endothelium, Vascular - immunology Female Heart Histamine - analysis Histamine - physiology Humans Macrophages - immunology Male Mast Cells - chemistry Mast Cells - physiology Medical sciences Middle Aged Muscle, Smooth, Vascular - chemistry Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - immunology Myocardial Infarction - immunology Myocardial Infarction - pathology T-Lymphocytes - immunology Tunica Intima - chemistry Tunica Intima - cytology Tunica Intima - immunology Vasoconstriction - physiology |
| title | Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery |
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