Elevated ovarian expression and serum concentration of α inhibin in the luteal phase during follicular development in the squirrel monkey (Saimiri boliviensis) compared to the human
The goal of the present investigation was to determine in the squirrel monkey the source and pattern of inhibin, a hormone known to effect reproductive steroid levels via pituitary and ovarian mechanisms. Since this seasonally polyestrous species is known to have elevated serum levels of reproductiv...
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Veröffentlicht in: | American journal of primatology 1999, Vol.47 (2), p.165-179 |
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container_title | American journal of primatology |
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creator | Yeoman, R.R. Crews, L.M. Zimmer, D.B. Dahl, K.D. Rizk, B. Abee, C.R. |
description | The goal of the present investigation was to determine in the squirrel monkey the source and pattern of inhibin, a hormone known to effect reproductive steroid levels via pituitary and ovarian mechanisms. Since this seasonally polyestrous species is known to have elevated serum levels of reproductive steroids compared to other primates, the levels of ovarian alpha subunit mRNA expression and serum total alpha inhibin, estradiol, progesterone, and luteinizing hormone were measured and compared to human levels. Expression of the alpha subunit was robust in monkey luteal tissue compared to expression in human luteal tissue. Squirrel monkey serum inhibin peaked 4 days after the luteinizing hormone surge and correlated with progesterone changes. These luteal serum levels of inhibin were greater than 12 times higher than the human levels yet bio‐LH activities were less than in the human during the luteal phase. Inhibin concentrations during the non‐breeding season were generally half the levels measured in the breeding season and undetectable in ovariectomized animals. However, exogenous FSH stimulation induced a marked rise in inhibin, which correlated with an estradiol rise. In conclusion, abundant alpha inhibin subunit expression in the luteal ovary of the squirrel monkey and loss of serum delectability in ovariectomized animals indicates that the principle source of inhibin in the squirrel monkey is the ovary. Elevated serum inhibin levels during the luteal phase concurrent with ovulatory‐size follicular development is unique among species studied thus far. Possible simultaneous inhibin production from both follicular and luteal tissue may be responsible for the exceptionally high inhibin levels. Am. J. Primatol. 47:165–179, 1999. © 1999 Wiley‐Liss, Inc. |
doi_str_mv | 10.1002/(SICI)1098-2345(1999)47:2<165::AID-AJP6>3.0.CO;2-3 |
format | Article |
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Since this seasonally polyestrous species is known to have elevated serum levels of reproductive steroids compared to other primates, the levels of ovarian alpha subunit mRNA expression and serum total alpha inhibin, estradiol, progesterone, and luteinizing hormone were measured and compared to human levels. Expression of the alpha subunit was robust in monkey luteal tissue compared to expression in human luteal tissue. Squirrel monkey serum inhibin peaked 4 days after the luteinizing hormone surge and correlated with progesterone changes. These luteal serum levels of inhibin were greater than 12 times higher than the human levels yet bio‐LH activities were less than in the human during the luteal phase. Inhibin concentrations during the non‐breeding season were generally half the levels measured in the breeding season and undetectable in ovariectomized animals. However, exogenous FSH stimulation induced a marked rise in inhibin, which correlated with an estradiol rise. In conclusion, abundant alpha inhibin subunit expression in the luteal ovary of the squirrel monkey and loss of serum delectability in ovariectomized animals indicates that the principle source of inhibin in the squirrel monkey is the ovary. Elevated serum inhibin levels during the luteal phase concurrent with ovulatory‐size follicular development is unique among species studied thus far. Possible simultaneous inhibin production from both follicular and luteal tissue may be responsible for the exceptionally high inhibin levels. Am. J. Primatol. 47:165–179, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0275-2565</identifier><identifier>EISSN: 1098-2345</identifier><identifier>DOI: 10.1002/(SICI)1098-2345(1999)47:2<165::AID-AJP6>3.0.CO;2-3</identifier><identifier>PMID: 9973269</identifier><identifier>CODEN: AJPTDU</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Americas ; Animals ; Biological and medical sciences ; Comparative analysis ; Female ; Fundamental and applied biological sciences. Psychology ; human ; Human physiology ; Humans ; inhibin ; Inhibins ; Luteal Phase ; Mammalian female genital system ; Menstrual Cycle - physiology ; Morphology. Physiology ; mRNA ; New World monkeys ; ovarian cycle ; Ovarian Follicle - physiology ; Ovary - metabolism ; ovulation induction ; Peptides - blood ; Physical anthropology ; Primates ; Reproduction ; Saimiri - blood ; Saimiri - physiology ; Seasons ; squirrel monkey ; Vertebrates: reproduction</subject><ispartof>American journal of primatology, 1999, Vol.47 (2), p.165-179</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291098-2345%281999%2947%3A2%3C165%3A%3AAID-AJP6%3E3.0.CO%3B2-3$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291098-2345%281999%2947%3A2%3C165%3A%3AAID-AJP6%3E3.0.CO%3B2-3$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1664164$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9973269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeoman, R.R.</creatorcontrib><creatorcontrib>Crews, L.M.</creatorcontrib><creatorcontrib>Zimmer, D.B.</creatorcontrib><creatorcontrib>Dahl, K.D.</creatorcontrib><creatorcontrib>Rizk, B.</creatorcontrib><creatorcontrib>Abee, C.R.</creatorcontrib><title>Elevated ovarian expression and serum concentration of α inhibin in the luteal phase during follicular development in the squirrel monkey (Saimiri boliviensis) compared to the human</title><title>American journal of primatology</title><addtitle>Am. J. Primatol</addtitle><description>The goal of the present investigation was to determine in the squirrel monkey the source and pattern of inhibin, a hormone known to effect reproductive steroid levels via pituitary and ovarian mechanisms. Since this seasonally polyestrous species is known to have elevated serum levels of reproductive steroids compared to other primates, the levels of ovarian alpha subunit mRNA expression and serum total alpha inhibin, estradiol, progesterone, and luteinizing hormone were measured and compared to human levels. Expression of the alpha subunit was robust in monkey luteal tissue compared to expression in human luteal tissue. Squirrel monkey serum inhibin peaked 4 days after the luteinizing hormone surge and correlated with progesterone changes. These luteal serum levels of inhibin were greater than 12 times higher than the human levels yet bio‐LH activities were less than in the human during the luteal phase. Inhibin concentrations during the non‐breeding season were generally half the levels measured in the breeding season and undetectable in ovariectomized animals. However, exogenous FSH stimulation induced a marked rise in inhibin, which correlated with an estradiol rise. In conclusion, abundant alpha inhibin subunit expression in the luteal ovary of the squirrel monkey and loss of serum delectability in ovariectomized animals indicates that the principle source of inhibin in the squirrel monkey is the ovary. Elevated serum inhibin levels during the luteal phase concurrent with ovulatory‐size follicular development is unique among species studied thus far. Possible simultaneous inhibin production from both follicular and luteal tissue may be responsible for the exceptionally high inhibin levels. Am. J. Primatol. 47:165–179, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Americas</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Comparative analysis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>human</subject><subject>Human physiology</subject><subject>Humans</subject><subject>inhibin</subject><subject>Inhibins</subject><subject>Luteal Phase</subject><subject>Mammalian female genital system</subject><subject>Menstrual Cycle - physiology</subject><subject>Morphology. Physiology</subject><subject>mRNA</subject><subject>New World monkeys</subject><subject>ovarian cycle</subject><subject>Ovarian Follicle - physiology</subject><subject>Ovary - metabolism</subject><subject>ovulation induction</subject><subject>Peptides - blood</subject><subject>Physical anthropology</subject><subject>Primates</subject><subject>Reproduction</subject><subject>Saimiri - blood</subject><subject>Saimiri - physiology</subject><subject>Seasons</subject><subject>squirrel monkey</subject><subject>Vertebrates: reproduction</subject><issn>0275-2565</issn><issn>1098-2345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9u0zAUhyMEGmPwCEi-QKi9SInt2Ik7hFSVsRUNWjH-3VlOckLNHCezk7I-Fjc8Bs9EspZyydWRfb7zs2V_QTDF0QRHEXkxulrMF2MciTQkNGYjLIQYx8mUvMScTaezxetw9nbFX9FJNJkvT0lI7wXHB_x-cByRhIWEcfYweOT99yjCOObsKDgSIqGEi-Pg15mBjWqhQPVGOa0sgtvGgfe6tkjZAnlwXYXy2uZgW6faYb8u0e-fSNu1zrTtK2rXgEzXgjKoWSsPqOictt9QWRuj884ohwrYgKmbqk_5O-FvOu0cGFTV9hq2aHSldKWdRllt9EaD9dqP-6OrRrn-gm19N7XuKmUfBw9KZTw82deT4NObs4_zi_Byeb6Yzy5DTRPBwzQlaZ5AWRZxBBEmNCVlyjKV5xiznFBRlpQTlWSs4FnCQBQFplwoEkP_cgLTk-D5Lrdx9U0HvpWV9jkYoyzUnZdcMM4xpv8FacoF5ynpwad7sMsqKGTjdKXcVu5_pO8_2_eVz5UpnbK59gcMcx5jHvfYhx32QxvY_mtHcjBHDuLIwQQ5mCAHcWScSNLPM9l7IwdvJJWRnC_7XXq37kPDXaj2LdweQpW7ljyhCZNf3p_LFRHvxOfVhfxK_wBOI84-</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Yeoman, R.R.</creator><creator>Crews, L.M.</creator><creator>Zimmer, D.B.</creator><creator>Dahl, K.D.</creator><creator>Rizk, B.</creator><creator>Abee, C.R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Elevated ovarian expression and serum concentration of α inhibin in the luteal phase during follicular development in the squirrel monkey (Saimiri boliviensis) compared to the human</title><author>Yeoman, R.R. ; Crews, L.M. ; Zimmer, D.B. ; Dahl, K.D. ; Rizk, B. ; Abee, C.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3796-8828c7effd40e012382f85bacc115c239ff362a7b5d6b75e9dd1369a24e275913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Americas</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Comparative analysis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>human</topic><topic>Human physiology</topic><topic>Humans</topic><topic>inhibin</topic><topic>Inhibins</topic><topic>Luteal Phase</topic><topic>Mammalian female genital system</topic><topic>Menstrual Cycle - physiology</topic><topic>Morphology. Physiology</topic><topic>mRNA</topic><topic>New World monkeys</topic><topic>ovarian cycle</topic><topic>Ovarian Follicle - physiology</topic><topic>Ovary - metabolism</topic><topic>ovulation induction</topic><topic>Peptides - blood</topic><topic>Physical anthropology</topic><topic>Primates</topic><topic>Reproduction</topic><topic>Saimiri - blood</topic><topic>Saimiri - physiology</topic><topic>Seasons</topic><topic>squirrel monkey</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeoman, R.R.</creatorcontrib><creatorcontrib>Crews, L.M.</creatorcontrib><creatorcontrib>Zimmer, D.B.</creatorcontrib><creatorcontrib>Dahl, K.D.</creatorcontrib><creatorcontrib>Rizk, B.</creatorcontrib><creatorcontrib>Abee, C.R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of primatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeoman, R.R.</au><au>Crews, L.M.</au><au>Zimmer, D.B.</au><au>Dahl, K.D.</au><au>Rizk, B.</au><au>Abee, C.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated ovarian expression and serum concentration of α inhibin in the luteal phase during follicular development in the squirrel monkey (Saimiri boliviensis) compared to the human</atitle><jtitle>American journal of primatology</jtitle><addtitle>Am. J. Primatol</addtitle><date>1999</date><risdate>1999</risdate><volume>47</volume><issue>2</issue><spage>165</spage><epage>179</epage><pages>165-179</pages><issn>0275-2565</issn><eissn>1098-2345</eissn><coden>AJPTDU</coden><abstract>The goal of the present investigation was to determine in the squirrel monkey the source and pattern of inhibin, a hormone known to effect reproductive steroid levels via pituitary and ovarian mechanisms. Since this seasonally polyestrous species is known to have elevated serum levels of reproductive steroids compared to other primates, the levels of ovarian alpha subunit mRNA expression and serum total alpha inhibin, estradiol, progesterone, and luteinizing hormone were measured and compared to human levels. Expression of the alpha subunit was robust in monkey luteal tissue compared to expression in human luteal tissue. Squirrel monkey serum inhibin peaked 4 days after the luteinizing hormone surge and correlated with progesterone changes. These luteal serum levels of inhibin were greater than 12 times higher than the human levels yet bio‐LH activities were less than in the human during the luteal phase. Inhibin concentrations during the non‐breeding season were generally half the levels measured in the breeding season and undetectable in ovariectomized animals. However, exogenous FSH stimulation induced a marked rise in inhibin, which correlated with an estradiol rise. In conclusion, abundant alpha inhibin subunit expression in the luteal ovary of the squirrel monkey and loss of serum delectability in ovariectomized animals indicates that the principle source of inhibin in the squirrel monkey is the ovary. Elevated serum inhibin levels during the luteal phase concurrent with ovulatory‐size follicular development is unique among species studied thus far. Possible simultaneous inhibin production from both follicular and luteal tissue may be responsible for the exceptionally high inhibin levels. Am. J. Primatol. 47:165–179, 1999. © 1999 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9973269</pmid><doi>10.1002/(SICI)1098-2345(1999)47:2<165::AID-AJP6>3.0.CO;2-3</doi><tpages>15</tpages></addata></record> |
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subjects | Adult Americas Animals Biological and medical sciences Comparative analysis Female Fundamental and applied biological sciences. Psychology human Human physiology Humans inhibin Inhibins Luteal Phase Mammalian female genital system Menstrual Cycle - physiology Morphology. Physiology mRNA New World monkeys ovarian cycle Ovarian Follicle - physiology Ovary - metabolism ovulation induction Peptides - blood Physical anthropology Primates Reproduction Saimiri - blood Saimiri - physiology Seasons squirrel monkey Vertebrates: reproduction |
title | Elevated ovarian expression and serum concentration of α inhibin in the luteal phase during follicular development in the squirrel monkey (Saimiri boliviensis) compared to the human |
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