Studies on the interaction of diflunisal ion with cyclodextrins using ion-selective electrode potentiometry

The interaction of diflunisal ion (DF) with β-cyclodextrin (βCD), γ-cyclodextrin (γCD), and hydroxypropyl-β-cyclodextrin (HPβCD) was studied in phosphate buffer, pH 7.4, at 5–37°C and various CD concentrations using a home-made diflunisal ion-selective electrode. Typical direct binding plots and Sca...

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Veröffentlicht in:	European journal of pharmaceutical sciences 1999-03, Vol.7 (4), p.271-278
Hauptverfasser:	Sideris, E.E., Valsami, G.N., Koupparis, M.A., Macheras, P.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anti-Inflammatory Agents, Non-Steroidal - chemistry Binding Biological and medical sciences Calibration Cooperative binding Cyclodextrins - chemistry Diflunisal Diflunisal - chemistry Electrodes General pharmacology Hill model Hydrogen-Ion Concentration Hydroxypropyl-β-cyclodextrin Indicators and Reagents Ion-selective electrodes Kinetics Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Potentiometry Scatchard model Temperature Thermodynamics β-Cyclodextrin γ-Cyclodextrin
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