Segmental pulmonary vascular responses to changes in pH in rat lungs: role of nitric oxide

Background: Respiratory or renal failure is associated with changes in blood pH. Changes in pH may have profound effects on vascular tone and reactivity. Site of action of acidosis in the pulmonary vasculature and the role of nitric oxide production remain unclear. Methods: We utilized isolated rat...

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Veröffentlicht in:	Acta anaesthesiologica Scandinavica 1999-01, Vol.43 (1), p.64-70
Hauptverfasser:	Gao, Y., Tassiopoulos, A. K., Mcgraw, D. J., Hauser, M. C., Camporesi, E. M., Hakim, T. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology acid-base Acidosis - etiology Acidosis - physiopathology Alkalosis - etiology Alkalosis - physiopathology Analysis of Variance Animals Biological and medical sciences Enzyme Inhibitors - pharmacology Hydrogen-Ion Concentration Hypercapnia - physiopathology Hypocapnia - physiopathology Lung - blood supply Male Medical sciences Microcirculation - drug effects Microcirculation - physiopathology Nitric oxide Nitric Oxide - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Pneumology Potassium Chloride - pharmacology Pulmonary Artery - drug effects Pulmonary Artery - physiopathology pulmonary vascular resistance Pulmonary Veins - drug effects Pulmonary Veins - physiopathology rat Rats Rats, Sprague-Dawley Renal Insufficiency - complications Respiratory Insufficiency - complications Respiratory system : syndromes and miscellaneous diseases segmental vascular resistance thromboxane vascular occlusion technique Vascular Resistance - drug effects Vascular Resistance - physiology Vasoconstriction - physiology Vasoconstrictor Agents - pharmacology Vasodilation - physiology Vasodilator Agents - pharmacology
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