Characterization of Allosteric Insulin Hexamers by Electrospray Ionization Mass Spectrometry

Electrospray mass spectrometry is used at pH 8.0 in combination with accurate mass measurements to confirm the multiplicity of insulin in stable noncovalent complexes with Zn(II) ions. Determination of the nature and number of ligands involved in Zn(II) chelation is in agreement with crystal and sol...

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Veröffentlicht in:	Analytical chemistry (Washington) 1999-01, Vol.71 (2), p.384-387
Hauptverfasser:	Fabris, D, Fenselau, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Insulin Insulin - chemistry Insulin - metabolism Mass Spectrometry - methods Measuring instruments Molecular Conformation Phenol - chemistry Proteins Zinc - chemistry Zinc - metabolism
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