Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function
Background/Aims: Primary graft dysfunction is difficult to predict. We have previously shown that indocyanine green clearance measured at 24 h following orthotopic liver transplantation predicts graft survival and outcome. We prospectively evaluated the use of indocyanine green clearance (with a cut...
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| Veröffentlicht in: | Journal of hepatology 1999, Vol.30 (1), p.142-148 |
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| creator | Plevris, John N Jalan, Rajiv Bzeizi, Khalid I Dollinger, Matthias M Lee, Alastair Garden, O.James Hayes, Peter C |
| description | Background/Aims: Primary graft dysfunction is difficult to predict. We have previously shown that indocyanine green clearance measured at 24 h following orthotopic liver transplantation predicts graft survival and outcome. We prospectively evaluated the use of indocyanine green clearance (with a cut-off value of 200 ml/min) as a marker of graft function following orthotopic liver transplantation and investigated its relationship with the markers of reperfusion injury during orthotopic liver transplantation.
Methods: In all patients indocyanine green clearance was measured at 24 h. Repeated blood samples were taken before, during the anhepatic and reperfusion phase and up to 12 h following orthotopic liver transplantation to measure the levels of neutrophil elastase and reactive oxygen intermediates. All patients studied had normal hepatic arterial pulse on Doppler-ultrasound post orthotopic liver transplantation.
Results: All patients with indocyanine green clearance >200 ml/min recovered following orthotopic liver transplantation and remained well up to 3 months of follow up. Four patients had an indocyanine green clearance |
| doi_str_mv | 10.1016/S0168-8278(99)80018-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69560883</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016882789980018X</els_id><sourcerecordid>69560883</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-32fa817115ceab9484a5df919ca3f385f9e445bfe4f9a592426c6bbd0bf0b03f3</originalsourceid><addsrcrecordid>eNqFkUtLAzEQgIMoWh8_QchBRA-ryb6anETEFxQ8qOAtZLMTiaTJmuxWevaPm22LHr1kAvPNg28QOqbkghJaXz6nh2Usn7Izzs8ZIZRlb1toQmtCMlKXdBtNfpE9tB_jByGkILzcRbuc51Na0wn6fnStV0vpjAP8HgAcVhZkkE4BDqAtqD6mTwdBD9F4h437GMISa2-t_zLuHVuzgID7VBI7K10v-xGTrsUmpoBTN7vEXYDWqN4H7HUaJHWP9eDUyB6iHS1thKNNPECvd7cvNw_Z7On-8eZ6lqmC8T4rci0ZnVJaKZANL1kpq1ZzypUsdMEqzaEsq0ZDqbmseF7mtaqbpiWNJg1JyAE6Xfftgv8cIPZibqICm5YGP0RR86omjBUJrNagCj7GZEF0wcxlWApKxChfrOSL0azgXKzki7dUd7wZMDRzaH-rNrZT_mSTl1FJq0fLJv41T0fL6YhdrTFIMhYGgojKQDpIa0I6h2i9-WeRHyimpS4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69560883</pqid></control><display><type>article</type><title>Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Plevris, John N ; Jalan, Rajiv ; Bzeizi, Khalid I ; Dollinger, Matthias M ; Lee, Alastair ; Garden, O.James ; Hayes, Peter C</creator><creatorcontrib>Plevris, John N ; Jalan, Rajiv ; Bzeizi, Khalid I ; Dollinger, Matthias M ; Lee, Alastair ; Garden, O.James ; Hayes, Peter C</creatorcontrib><description>Background/Aims: Primary graft dysfunction is difficult to predict. We have previously shown that indocyanine green clearance measured at 24 h following orthotopic liver transplantation predicts graft survival and outcome. We prospectively evaluated the use of indocyanine green clearance (with a cut-off value of 200 ml/min) as a marker of graft function following orthotopic liver transplantation and investigated its relationship with the markers of reperfusion injury during orthotopic liver transplantation.
Methods: In all patients indocyanine green clearance was measured at 24 h. Repeated blood samples were taken before, during the anhepatic and reperfusion phase and up to 12 h following orthotopic liver transplantation to measure the levels of neutrophil elastase and reactive oxygen intermediates. All patients studied had normal hepatic arterial pulse on Doppler-ultrasound post orthotopic liver transplantation.
Results: All patients with indocyanine green clearance >200 ml/min recovered following orthotopic liver transplantation and remained well up to 3 months of follow up. Four patients had an indocyanine green clearance <200 ml/min; three were re-transplanted for graft failure within 3 days of the transplant, while one survived after prolonged intensive support and hospitalization. Indocyanine green clearance significantly correlated with reactive oxygen intermediates production and neutrophil elastase during orthotopic liver transplantation (
r=−0.61,
p<0.002 and
r=−0.66,
p<0.0009, respectively). Indocyanine green clearance was also significantly correlated with alanine aminotransferase and prothrombin time at 24 h post-transplantation (
r=−0.35,
p<0.02 and
r=−0.4,
p<0.0077, respectively).
Conclusion: Indocyanine green reflects the degree of reperfusion injury and is a good early marker of primary graft function. Indocyanine green clearance over 200 ml/min is associated with favorable outcome.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(99)80018-X</identifier><identifier>PMID: 9927161</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Coloring Agents - pharmacokinetics ; Female ; Follow-Up Studies ; Hepatic Artery - diagnostic imaging ; Humans ; Indocyanine Green - pharmacokinetics ; Indocyanine green clearance ; Intraoperative Period ; Leukocyte Elastase - blood ; Liver - physiopathology ; Liver Transplantation ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Middle Aged ; Neutrophil elastase ; Postoperative Period ; Prognosis ; Prospective Studies ; Reactive oxygen intermediates ; Reactive Oxygen Species - metabolism ; Reoperation ; Reperfusion Injury - blood ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Ultrasonography</subject><ispartof>Journal of hepatology, 1999, Vol.30 (1), p.142-148</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-32fa817115ceab9484a5df919ca3f385f9e445bfe4f9a592426c6bbd0bf0b03f3</citedby><cites>FETCH-LOGICAL-c389t-32fa817115ceab9484a5df919ca3f385f9e445bfe4f9a592426c6bbd0bf0b03f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016882789980018X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1641211$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9927161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plevris, John N</creatorcontrib><creatorcontrib>Jalan, Rajiv</creatorcontrib><creatorcontrib>Bzeizi, Khalid I</creatorcontrib><creatorcontrib>Dollinger, Matthias M</creatorcontrib><creatorcontrib>Lee, Alastair</creatorcontrib><creatorcontrib>Garden, O.James</creatorcontrib><creatorcontrib>Hayes, Peter C</creatorcontrib><title>Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background/Aims: Primary graft dysfunction is difficult to predict. We have previously shown that indocyanine green clearance measured at 24 h following orthotopic liver transplantation predicts graft survival and outcome. We prospectively evaluated the use of indocyanine green clearance (with a cut-off value of 200 ml/min) as a marker of graft function following orthotopic liver transplantation and investigated its relationship with the markers of reperfusion injury during orthotopic liver transplantation.
Methods: In all patients indocyanine green clearance was measured at 24 h. Repeated blood samples were taken before, during the anhepatic and reperfusion phase and up to 12 h following orthotopic liver transplantation to measure the levels of neutrophil elastase and reactive oxygen intermediates. All patients studied had normal hepatic arterial pulse on Doppler-ultrasound post orthotopic liver transplantation.
Results: All patients with indocyanine green clearance >200 ml/min recovered following orthotopic liver transplantation and remained well up to 3 months of follow up. Four patients had an indocyanine green clearance <200 ml/min; three were re-transplanted for graft failure within 3 days of the transplant, while one survived after prolonged intensive support and hospitalization. Indocyanine green clearance significantly correlated with reactive oxygen intermediates production and neutrophil elastase during orthotopic liver transplantation (
r=−0.61,
p<0.002 and
r=−0.66,
p<0.0009, respectively). Indocyanine green clearance was also significantly correlated with alanine aminotransferase and prothrombin time at 24 h post-transplantation (
r=−0.35,
p<0.02 and
r=−0.4,
p<0.0077, respectively).
Conclusion: Indocyanine green reflects the degree of reperfusion injury and is a good early marker of primary graft function. Indocyanine green clearance over 200 ml/min is associated with favorable outcome.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Coloring Agents - pharmacokinetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hepatic Artery - diagnostic imaging</subject><subject>Humans</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Indocyanine green clearance</subject><subject>Intraoperative Period</subject><subject>Leukocyte Elastase - blood</subject><subject>Liver - physiopathology</subject><subject>Liver Transplantation</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophil elastase</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Reactive oxygen intermediates</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Reoperation</subject><subject>Reperfusion Injury - blood</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Ultrasonography</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEQgIMoWh8_QchBRA-ryb6anETEFxQ8qOAtZLMTiaTJmuxWevaPm22LHr1kAvPNg28QOqbkghJaXz6nh2Usn7Izzs8ZIZRlb1toQmtCMlKXdBtNfpE9tB_jByGkILzcRbuc51Na0wn6fnStV0vpjAP8HgAcVhZkkE4BDqAtqD6mTwdBD9F4h437GMISa2-t_zLuHVuzgID7VBI7K10v-xGTrsUmpoBTN7vEXYDWqN4H7HUaJHWP9eDUyB6iHS1thKNNPECvd7cvNw_Z7On-8eZ6lqmC8T4rci0ZnVJaKZANL1kpq1ZzypUsdMEqzaEsq0ZDqbmseF7mtaqbpiWNJg1JyAE6Xfftgv8cIPZibqICm5YGP0RR86omjBUJrNagCj7GZEF0wcxlWApKxChfrOSL0azgXKzki7dUd7wZMDRzaH-rNrZT_mSTl1FJq0fLJv41T0fL6YhdrTFIMhYGgojKQDpIa0I6h2i9-WeRHyimpS4</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Plevris, John N</creator><creator>Jalan, Rajiv</creator><creator>Bzeizi, Khalid I</creator><creator>Dollinger, Matthias M</creator><creator>Lee, Alastair</creator><creator>Garden, O.James</creator><creator>Hayes, Peter C</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function</title><author>Plevris, John N ; Jalan, Rajiv ; Bzeizi, Khalid I ; Dollinger, Matthias M ; Lee, Alastair ; Garden, O.James ; Hayes, Peter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-32fa817115ceab9484a5df919ca3f385f9e445bfe4f9a592426c6bbd0bf0b03f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Coloring Agents - pharmacokinetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hepatic Artery - diagnostic imaging</topic><topic>Humans</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Indocyanine green clearance</topic><topic>Intraoperative Period</topic><topic>Leukocyte Elastase - blood</topic><topic>Liver - physiopathology</topic><topic>Liver Transplantation</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophil elastase</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Reactive oxygen intermediates</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Reoperation</topic><topic>Reperfusion Injury - blood</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plevris, John N</creatorcontrib><creatorcontrib>Jalan, Rajiv</creatorcontrib><creatorcontrib>Bzeizi, Khalid I</creatorcontrib><creatorcontrib>Dollinger, Matthias M</creatorcontrib><creatorcontrib>Lee, Alastair</creatorcontrib><creatorcontrib>Garden, O.James</creatorcontrib><creatorcontrib>Hayes, Peter C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plevris, John N</au><au>Jalan, Rajiv</au><au>Bzeizi, Khalid I</au><au>Dollinger, Matthias M</au><au>Lee, Alastair</au><au>Garden, O.James</au><au>Hayes, Peter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1999</date><risdate>1999</risdate><volume>30</volume><issue>1</issue><spage>142</spage><epage>148</epage><pages>142-148</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>Background/Aims: Primary graft dysfunction is difficult to predict. We have previously shown that indocyanine green clearance measured at 24 h following orthotopic liver transplantation predicts graft survival and outcome. We prospectively evaluated the use of indocyanine green clearance (with a cut-off value of 200 ml/min) as a marker of graft function following orthotopic liver transplantation and investigated its relationship with the markers of reperfusion injury during orthotopic liver transplantation.
Methods: In all patients indocyanine green clearance was measured at 24 h. Repeated blood samples were taken before, during the anhepatic and reperfusion phase and up to 12 h following orthotopic liver transplantation to measure the levels of neutrophil elastase and reactive oxygen intermediates. All patients studied had normal hepatic arterial pulse on Doppler-ultrasound post orthotopic liver transplantation.
Results: All patients with indocyanine green clearance >200 ml/min recovered following orthotopic liver transplantation and remained well up to 3 months of follow up. Four patients had an indocyanine green clearance <200 ml/min; three were re-transplanted for graft failure within 3 days of the transplant, while one survived after prolonged intensive support and hospitalization. Indocyanine green clearance significantly correlated with reactive oxygen intermediates production and neutrophil elastase during orthotopic liver transplantation (
r=−0.61,
p<0.002 and
r=−0.66,
p<0.0009, respectively). Indocyanine green clearance was also significantly correlated with alanine aminotransferase and prothrombin time at 24 h post-transplantation (
r=−0.35,
p<0.02 and
r=−0.4,
p<0.0077, respectively).
Conclusion: Indocyanine green reflects the degree of reperfusion injury and is a good early marker of primary graft function. Indocyanine green clearance over 200 ml/min is associated with favorable outcome.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>9927161</pmid><doi>10.1016/S0168-8278(99)80018-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of hepatology, 1999, Vol.30 (1), p.142-148 |
| issn | 0168-8278 1600-0641 |
| language | eng |
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| subjects | Adult Biological and medical sciences Coloring Agents - pharmacokinetics Female Follow-Up Studies Hepatic Artery - diagnostic imaging Humans Indocyanine Green - pharmacokinetics Indocyanine green clearance Intraoperative Period Leukocyte Elastase - blood Liver - physiopathology Liver Transplantation Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Middle Aged Neutrophil elastase Postoperative Period Prognosis Prospective Studies Reactive oxygen intermediates Reactive Oxygen Species - metabolism Reoperation Reperfusion Injury - blood Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Ultrasonography |
| title | Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function |
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