Identification of Tyrosine Phosphorylation Sites in Human Gab-1 Protein by EGF Receptor Kinase in Vitro

Grb2-associated binder-1 (Gab-1) has been identified recently in a cDNA library of glioblastoma tumors and appears to play a central role in cellular growth response, transformation, and apoptosis. Structural and functional features indicate that Gab-1 is a multisubstrate docking protein downstream...

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Veröffentlicht in:	Biochemistry (Easton) 1999-01, Vol.38 (1), p.151-159
Hauptverfasser:	Lehr, Stefan, Kotzka, Jörg, Herkner, Armin, Klein, Elfriede, Siethoff, Christoph, Knebel, Birgit, Noelle, Volker, Brüning, Jens C, Klein, Helmut W, Meyer, Helmut E, Krone, Wilhelm, Müller-Wieland, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Base Sequence Cell Fractionation Humans Kinetics Molecular Sequence Data Phosphoamino Acids - analysis Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Receptor, Epidermal Growth Factor - metabolism Recombinant Fusion Proteins - analysis Recombinant Fusion Proteins - biosynthesis Tumor Cells, Cultured Tyrosine - metabolism
Online-Zugang:	Volltext
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