Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism
There are two thyroid hormones, thyroxine and triiodothyronine. The daily production of thyroxine is about 100 μg, all produced by the thyroid gland. The daily production of triiodothyronine is about 30 μg, of which about 20 percent is produced by the thyroid gland and 80 percent by deiodination of...
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| Veröffentlicht in: | The New England journal of medicine 1999-02, Vol.340 (6), p.424-429 |
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| creator | Bunevičius, Robertas Kažanavičius, Gintautas Žalinkevičius, Rimas Prange, Arthur J |
| description | There are two thyroid hormones, thyroxine and triiodothyronine. The daily production of thyroxine is about 100 μg, all produced by the thyroid gland. The daily production of triiodothyronine is about 30 μg, of which about 20 percent is produced by the thyroid gland and 80 percent by deiodination of thyroxine in extrathyroidal tissues.
1
Not all tissues that need thyroid hormone are equally able to convert thyroxine to triiodothyronine, the active form of the hormone.
2
Nevertheless, most patients with hypothyroidism are treated only with thyroxine (levothyroxine). Although this treatment is effective, some patients with hypothyroidism treated with thyroxine are not entirely . . . |
| doi_str_mv | 10.1056/NEJM199902113400603 |
| format | Article |
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1
Not all tissues that need thyroid hormone are equally able to convert thyroxine to triiodothyronine, the active form of the hormone.
2
Nevertheless, most patients with hypothyroidism are treated only with thyroxine (levothyroxine). Although this treatment is effective, some patients with hypothyroidism treated with thyroxine are not entirely . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199902113400603</identifier><identifier>PMID: 9971866</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Affect - drug effects ; Biological and medical sciences ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Hormones ; Hormones. Endocrine system ; Humans ; Hypothyroidism ; Hypothyroidism - blood ; Hypothyroidism - drug therapy ; Hypothyroidism - psychology ; Male ; Medical sciences ; Middle Aged ; Patients ; Pharmacology. Drug treatments ; Psychometrics ; Sex Hormone-Binding Globulin - analysis ; Thyroid cancer ; Thyroid gland ; Thyrotropin - blood ; Thyroxine - blood ; Thyroxine - therapeutic use ; Treatment Outcome ; Triiodothyronine - blood ; Triiodothyronine - therapeutic use</subject><ispartof>The New England journal of medicine, 1999-02, Vol.340 (6), p.424-429</ispartof><rights>Copyright © 1999 Massachusetts Medical Society. All rights reserved.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-7a576fcd23348fec57bab3685156a3b4483df0199fa377c53de1f545fd74cca63</citedby><cites>FETCH-LOGICAL-c526t-7a576fcd23348fec57bab3685156a3b4483df0199fa377c53de1f545fd74cca63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199902113400603$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199902113400603$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1676856$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9971866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bunevičius, Robertas</creatorcontrib><creatorcontrib>Kažanavičius, Gintautas</creatorcontrib><creatorcontrib>Žalinkevičius, Rimas</creatorcontrib><creatorcontrib>Prange, Arthur J</creatorcontrib><title>Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>There are two thyroid hormones, thyroxine and triiodothyronine. The daily production of thyroxine is about 100 μg, all produced by the thyroid gland. The daily production of triiodothyronine is about 30 μg, of which about 20 percent is produced by the thyroid gland and 80 percent by deiodination of thyroxine in extrathyroidal tissues.
1
Not all tissues that need thyroid hormone are equally able to convert thyroxine to triiodothyronine, the active form of the hormone.
2
Nevertheless, most patients with hypothyroidism are treated only with thyroxine (levothyroxine). Although this treatment is effective, some patients with hypothyroidism treated with thyroxine are not entirely . . .</description><subject>Adult</subject><subject>Affect - drug effects</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Hormones</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - drug therapy</subject><subject>Hypothyroidism - psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychometrics</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Thyroid cancer</subject><subject>Thyroid gland</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Triiodothyronine - blood</subject><subject>Triiodothyronine - therapeutic use</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV1LwzAUhoMoc05_gQhFxBupJs1XcyljOsWvi3ldsjTBjLapSYvu35u5oSJibgLnfd435-QAcIjgOYKUXTxMbu-REAJmCGECIYN4CwwRxTglBLJtMIQwy1PCBd4FeyEsYDyIiAEYCMFRztgQ6IkxWnUhcSaZvSy9e7eNTmRIxq5upddl8ma7lx9SW_UhmXlrXem6VbVZVW2TPMnO6iYmfRqmy3Yt29KGeh_sGFkFfbC5R-D5ajIbT9O7x-ub8eVdqmjGupRLyplRZYYxyWNblM_lHLOcIsoknhOS49LAOLKRmHNFcamRoYSakhOlJMMjcLrObb177XXoitoGpatKNtr1oWCCUsEhjODxL3Dhet_E3oosw4LgLBMRwmtIeReC16Zova2lXxYIFqsNFH9sILqONtH9vNbll2fz5VE_2egyKFkZLxtlw3c043HgFXa2xuo6FI1e1P8--gF-Kprv</recordid><startdate>19990211</startdate><enddate>19990211</enddate><creator>Bunevičius, Robertas</creator><creator>Kažanavičius, Gintautas</creator><creator>Žalinkevičius, Rimas</creator><creator>Prange, Arthur J</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990211</creationdate><title>Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism</title><author>Bunevičius, Robertas ; Kažanavičius, Gintautas ; Žalinkevičius, Rimas ; Prange, Arthur J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-7a576fcd23348fec57bab3685156a3b4483df0199fa377c53de1f545fd74cca63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Affect - drug effects</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Hormones</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - blood</topic><topic>Hypothyroidism - drug therapy</topic><topic>Hypothyroidism - psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychometrics</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Thyroid cancer</topic><topic>Thyroid gland</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Triiodothyronine - blood</topic><topic>Triiodothyronine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bunevičius, Robertas</creatorcontrib><creatorcontrib>Kažanavičius, Gintautas</creatorcontrib><creatorcontrib>Žalinkevičius, Rimas</creatorcontrib><creatorcontrib>Prange, Arthur J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bunevičius, Robertas</au><au>Kažanavičius, Gintautas</au><au>Žalinkevičius, Rimas</au><au>Prange, Arthur J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1999-02-11</date><risdate>1999</risdate><volume>340</volume><issue>6</issue><spage>424</spage><epage>429</epage><pages>424-429</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>There are two thyroid hormones, thyroxine and triiodothyronine. The daily production of thyroxine is about 100 μg, all produced by the thyroid gland. The daily production of triiodothyronine is about 30 μg, of which about 20 percent is produced by the thyroid gland and 80 percent by deiodination of thyroxine in extrathyroidal tissues.
1
Not all tissues that need thyroid hormone are equally able to convert thyroxine to triiodothyronine, the active form of the hormone.
2
Nevertheless, most patients with hypothyroidism are treated only with thyroxine (levothyroxine). Although this treatment is effective, some patients with hypothyroidism treated with thyroxine are not entirely . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9971866</pmid><doi>10.1056/NEJM199902113400603</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1999-02, Vol.340 (6), p.424-429 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Adult Affect - drug effects Biological and medical sciences Double-Blind Method Drug Therapy, Combination Female Hormones Hormones. Endocrine system Humans Hypothyroidism Hypothyroidism - blood Hypothyroidism - drug therapy Hypothyroidism - psychology Male Medical sciences Middle Aged Patients Pharmacology. Drug treatments Psychometrics Sex Hormone-Binding Globulin - analysis Thyroid cancer Thyroid gland Thyrotropin - blood Thyroxine - blood Thyroxine - therapeutic use Treatment Outcome Triiodothyronine - blood Triiodothyronine - therapeutic use |
| title | Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism |
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