Structural Characteristics of Phosphoramide Derivatives as Urease Inhibitors. Requirements for Activity

Taking as a reference the structural characteristics of a set of compounds that act as jack bean (Canavalia ensiformis) urease inhibitors, namely, phenylphosphorodiamidate (PPD), N-n-butylthiophosphorictriamide (NBPT), and N-n-butylphosphorictriamide (NBPTO), we have studied the structure−activity r...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2008-09, Vol.56 (18), p.8451-8460
Hauptverfasser:	Font, María, Domínguez, María-José, Sanmartín, Carmen, Palop, Juan A, San-Francisco, Sara, Urrutia, Oscar, Houdusse, Fabrice, García-Mina, José M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Binding Sites Biological and medical sciences Canavalia ensiformis Chemical Aspects of Biotechnology/Molecular Biology chemical structure Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology fertilizers Food industries Fundamental and applied biological sciences. Psychology hydrogen bonding Models, Molecular molecular conformation molecular models N-n-butylthiophosphorictriamide phosphoramide derivatives Phosphoramides Phosphoric Acids - chemistry Phosphoric Acids - pharmacology Structure-Activity Relationship structure-activity relationships urea Urease - antagonists & inhibitors Urease inhibitors
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