Competitive PCR to detect eIF4E gene amplification in head and neck cancer

Background The protein eukaryotic initiation factor 4E (eIF4E) binds to messenger ribonucleic acid (mRNA) as the initial step in protein synthesis. Overexpression of eIF4E results in upregulation of specific proteins essential to cell growth and division. Overexpression of eIF4E has been found in he...

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Veröffentlicht in:	Head & neck 1999-01, Vol.21 (1), p.60-65
Hauptverfasser:	Sorrells, Donald L., Ghali, Ghali E., Meschonat, Carol, DeFatta, Robert J., Black, Destin, Liu, Li, Benedetti, Arrigo De, Nathan, Cherie-Ann O., Li, Benjamin D. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Blotting, Western Carcinoma, Squamous Cell - genetics eIF4E gene amplification Eukaryotic Initiation Factor-4E Fundamental and applied biological sciences. Psychology Gene Expression Genetic engineering Genetic technics Head and Neck Neoplasms - genetics head and neck squamous cell carcinoma Humans In vitro gene amplification. Pcr technique Methods. Procedures. Technologies Peptide Initiation Factors polymerase chain reaction Polymerase Chain Reaction - methods
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