Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast Cancer cells

Activation of the enzyme telomerase, which has been associated with cellular immortality, may constitute a key step in the development of human cancer. Telomerase is repressed in most normal human somatic cells. This study was conducted, using a genetic complementation approach, with the aim of iden...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1999-01, Vol.91 (1), p.37-45
Hauptverfasser:	CUTHBERT, A. P, BOND, J, TROTT, D. A, GILL, S, BRONI, J, MARRIOTT, A, KHOUDOLI, G, PARKINSON, E. K, COOPER, C. S, NEWBOLD, R. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Breast cancer Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - enzymology Carcinoma, Intraductal, Noninfiltrating - pathology Cell Division - drug effects Cell Fusion Chromosomes - metabolism Chromosomes - ultrastructure Chromosomes, Human, Pair 3 - genetics Enzymes Female Gene Expression Regulation, Enzymologic Gene Transfer Techniques General aspects (metabolism, cell proliferation, established cell line...) Genes Genetics Growth Inhibitors - genetics Growth Inhibitors - physiology Gynecology. Andrology. Obstetrics Humans Hybrid Cells In Situ Hybridization, Fluorescence Mammary gland diseases Medical sciences Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Polymerase Chain Reaction Repressor Proteins - genetics Repressor Proteins - physiology Telomerase - biosynthesis Telomerase - genetics Telomerase - physiology Telomere - metabolism Tumor cell Tumor Cells, Cultured Tumors
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