Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity
Serum proteins, serum immunoglobulins, anti‐nuclear antibodies (ANA), antismooth muscle antibodies (ASMA), anti‐mitochondrial antibodies (AMA), anti‐liver‐kidney antibodies (LKM), anti‐parietal‐cell gastric antibodies (APCA), anti‐epithelial antibodies and concomitant autoimmune disease were studied...
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| Veröffentlicht in: | Journal of oral pathology & medicine 1999-01, Vol.28 (1), p.16-19 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Carrozzo, M. Gandolfo, S. Lodi, G. Carbone, M. Garzino-Demo, P. Carbonero, C. Porter, S. R. Scully, C. |
| description | Serum proteins, serum immunoglobulins, anti‐nuclear antibodies (ANA), antismooth muscle antibodies (ASMA), anti‐mitochondrial antibodies (AMA), anti‐liver‐kidney antibodies (LKM), anti‐parietal‐cell gastric antibodies (APCA), anti‐epithelial antibodies and concomitant autoimmune disease were studied in 27 OLP‐HCV+ve subjects and in a comparable group of 23 who were OLP‐HCV‐ve. In addition, all the patients with chronic liver disease who were seropositive for ANA, AMA or LKM were scored using the new aggregate scoring system to detect those with the accepted criteria for the diagnosis of autoimmune hepatitis (AIH). Hypergammaglobulinemia was more frequent in OLP‐HCV+ve than in OLP‐HCV‐ve (P=0.008) subjects. Serum IgG and IgM levels were higher in HCV+ve than in HCV‐ve (respectively, P=0.017 and P=0.018) individuals. However, there was no difference in the frequency of any autoantibody between OLP‐HCV+ve and OLP‐HCV‐ve patients. Overall, immunologically‐related abnormalities were found in 17(63%) OLP‐HCV+ve and 11(48%) OLP‐HCV‐ve (P=0.43) patients. Three OLP‐HCV‐ve and no OLP‐HCV+ve patients had score criteria of probable AIH. The present and our previous data suggest that OLP patients with HCV infection neither had evidence of autoimmune liver damage nor had abnormal humoral immune‐responses, with the exception of higher than control levels of serum immunoglobulins. Cryoglobulins may be responsible. |
| doi_str_mv | 10.1111/j.1600-0714.1999.tb01988.x |
| format | Article |
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R. ; Scully, C.</creator><creatorcontrib>Carrozzo, M. ; Gandolfo, S. ; Lodi, G. ; Carbone, M. ; Garzino-Demo, P. ; Carbonero, C. ; Porter, S. R. ; Scully, C.</creatorcontrib><description>Serum proteins, serum immunoglobulins, anti‐nuclear antibodies (ANA), antismooth muscle antibodies (ASMA), anti‐mitochondrial antibodies (AMA), anti‐liver‐kidney antibodies (LKM), anti‐parietal‐cell gastric antibodies (APCA), anti‐epithelial antibodies and concomitant autoimmune disease were studied in 27 OLP‐HCV+ve subjects and in a comparable group of 23 who were OLP‐HCV‐ve. In addition, all the patients with chronic liver disease who were seropositive for ANA, AMA or LKM were scored using the new aggregate scoring system to detect those with the accepted criteria for the diagnosis of autoimmune hepatitis (AIH). Hypergammaglobulinemia was more frequent in OLP‐HCV+ve than in OLP‐HCV‐ve (P=0.008) subjects. Serum IgG and IgM levels were higher in HCV+ve than in HCV‐ve (respectively, P=0.017 and P=0.018) individuals. However, there was no difference in the frequency of any autoantibody between OLP‐HCV+ve and OLP‐HCV‐ve patients. Overall, immunologically‐related abnormalities were found in 17(63%) OLP‐HCV+ve and 11(48%) OLP‐HCV‐ve (P=0.43) patients. Three OLP‐HCV‐ve and no OLP‐HCV+ve patients had score criteria of probable AIH. The present and our previous data suggest that OLP patients with HCV infection neither had evidence of autoimmune liver damage nor had abnormal humoral immune‐responses, with the exception of higher than control levels of serum immunoglobulins. Cryoglobulins may be responsible.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.1999.tb01988.x</identifier><identifier>PMID: 9890452</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antibodies, Antinuclear - blood ; Autoantibodies - blood ; autoimmunity ; Autoimmunity - immunology ; Biological and medical sciences ; Blood Proteins - analysis ; Cryoglobulins - immunology ; Dentistry ; Epithelial Cells - immunology ; Female ; Hepatitis C - immunology ; hepatitis C virus ; Humans ; Hypergammaglobulinemia - blood ; Hypergammaglobulinemia - immunology ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Kidney - immunology ; Lichen Planus, Oral - immunology ; Liver - immunology ; Liver Diseases - immunology ; Male ; Medical sciences ; Middle Aged ; Mitochondria - immunology ; Muscle, Smooth - immunology ; Non tumoral diseases ; oral lichen planus ; Otorhinolaryngology. Stomatology ; Parietal Cells, Gastric - immunology ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of oral pathology & medicine, 1999-01, Vol.28 (1), p.16-19</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-909251f03b6606ff7e8993967eaa875097a01b79ee504dc96d7b758cfc98f1d73</citedby><cites>FETCH-LOGICAL-c4356-909251f03b6606ff7e8993967eaa875097a01b79ee504dc96d7b758cfc98f1d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.1999.tb01988.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.1999.tb01988.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1602316$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9890452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrozzo, M.</creatorcontrib><creatorcontrib>Gandolfo, S.</creatorcontrib><creatorcontrib>Lodi, G.</creatorcontrib><creatorcontrib>Carbone, M.</creatorcontrib><creatorcontrib>Garzino-Demo, P.</creatorcontrib><creatorcontrib>Carbonero, C.</creatorcontrib><creatorcontrib>Porter, S. R.</creatorcontrib><creatorcontrib>Scully, C.</creatorcontrib><title>Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Serum proteins, serum immunoglobulins, anti‐nuclear antibodies (ANA), antismooth muscle antibodies (ASMA), anti‐mitochondrial antibodies (AMA), anti‐liver‐kidney antibodies (LKM), anti‐parietal‐cell gastric antibodies (APCA), anti‐epithelial antibodies and concomitant autoimmune disease were studied in 27 OLP‐HCV+ve subjects and in a comparable group of 23 who were OLP‐HCV‐ve. In addition, all the patients with chronic liver disease who were seropositive for ANA, AMA or LKM were scored using the new aggregate scoring system to detect those with the accepted criteria for the diagnosis of autoimmune hepatitis (AIH). Hypergammaglobulinemia was more frequent in OLP‐HCV+ve than in OLP‐HCV‐ve (P=0.008) subjects. Serum IgG and IgM levels were higher in HCV+ve than in HCV‐ve (respectively, P=0.017 and P=0.018) individuals. However, there was no difference in the frequency of any autoantibody between OLP‐HCV+ve and OLP‐HCV‐ve patients. Overall, immunologically‐related abnormalities were found in 17(63%) OLP‐HCV+ve and 11(48%) OLP‐HCV‐ve (P=0.43) patients. Three OLP‐HCV‐ve and no OLP‐HCV+ve patients had score criteria of probable AIH. The present and our previous data suggest that OLP patients with HCV infection neither had evidence of autoimmune liver damage nor had abnormal humoral immune‐responses, with the exception of higher than control levels of serum immunoglobulins. Cryoglobulins may be responsible.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Antinuclear - blood</subject><subject>Autoantibodies - blood</subject><subject>autoimmunity</subject><subject>Autoimmunity - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - analysis</subject><subject>Cryoglobulins - immunology</subject><subject>Dentistry</subject><subject>Epithelial Cells - immunology</subject><subject>Female</subject><subject>Hepatitis C - immunology</subject><subject>hepatitis C virus</subject><subject>Humans</subject><subject>Hypergammaglobulinemia - blood</subject><subject>Hypergammaglobulinemia - immunology</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Kidney - immunology</subject><subject>Lichen Planus, Oral - immunology</subject><subject>Liver - immunology</subject><subject>Liver Diseases - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitochondria - immunology</subject><subject>Muscle, Smooth - immunology</subject><subject>Non tumoral diseases</subject><subject>oral lichen planus</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Parietal Cells, Gastric - immunology</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFuP0zAQhS0EWsrCT0CyEOItwW5iO16JB1TRXVYrihCXR8txxtQll2I7bPvv16FRecYvHuucMzP-EHpFSU7TebvLKSckI4KWOZVS5rEmVFZVfniEFmfpMVoQScpsyejyKXoWwo4QKoqSXqALWSWFLRfo58brFrfObKHH-1b3Y8AuVTo66ONUWzARGjx43A_9-Xnv4hZvYfJFF_AK_3F-DFc4bgH7oQU8WKzHOLiuG3sXj8_RE6vbAC_m-xJ9W3_4urrJ7jbXH1fv7zJTFoxnksi0riVFzTnh1gqopCwkF6B1JRiRQhNaCwnASNkYyRtRC1YZa2RlaSOKS_Tm1Hfvh98jhKg6Fwy06WcwjEFxyZigrEzGq5PR-CEED1btveu0PypK1ERZ7dSEUk0o1URZzZTVIYVfzlPGuoPmHJ2xJv31rOtgdGu97o0L_yZwsiwoT7Z3J9u9a-H4Hwuo283nv_nslHchwuGc1_6X4qIQTP34dK1WX76X69v1WrHiAcn5qQ4</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Carrozzo, M.</creator><creator>Gandolfo, S.</creator><creator>Lodi, G.</creator><creator>Carbone, M.</creator><creator>Garzino-Demo, P.</creator><creator>Carbonero, C.</creator><creator>Porter, S. R.</creator><creator>Scully, C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity</title><author>Carrozzo, M. ; Gandolfo, S. ; Lodi, G. ; Carbone, M. ; Garzino-Demo, P. ; Carbonero, C. ; Porter, S. R. ; Scully, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-909251f03b6606ff7e8993967eaa875097a01b79ee504dc96d7b758cfc98f1d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Antinuclear - blood</topic><topic>Autoantibodies - blood</topic><topic>autoimmunity</topic><topic>Autoimmunity - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - analysis</topic><topic>Cryoglobulins - immunology</topic><topic>Dentistry</topic><topic>Epithelial Cells - immunology</topic><topic>Female</topic><topic>Hepatitis C - immunology</topic><topic>hepatitis C virus</topic><topic>Humans</topic><topic>Hypergammaglobulinemia - blood</topic><topic>Hypergammaglobulinemia - immunology</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Kidney - immunology</topic><topic>Lichen Planus, Oral - immunology</topic><topic>Liver - immunology</topic><topic>Liver Diseases - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitochondria - immunology</topic><topic>Muscle, Smooth - immunology</topic><topic>Non tumoral diseases</topic><topic>oral lichen planus</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Parietal Cells, Gastric - immunology</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrozzo, M.</creatorcontrib><creatorcontrib>Gandolfo, S.</creatorcontrib><creatorcontrib>Lodi, G.</creatorcontrib><creatorcontrib>Carbone, M.</creatorcontrib><creatorcontrib>Garzino-Demo, P.</creatorcontrib><creatorcontrib>Carbonero, C.</creatorcontrib><creatorcontrib>Porter, S. R.</creatorcontrib><creatorcontrib>Scully, C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrozzo, M.</au><au>Gandolfo, S.</au><au>Lodi, G.</au><au>Carbone, M.</au><au>Garzino-Demo, P.</au><au>Carbonero, C.</au><au>Porter, S. R.</au><au>Scully, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>1999-01</date><risdate>1999</risdate><volume>28</volume><issue>1</issue><spage>16</spage><epage>19</epage><pages>16-19</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Serum proteins, serum immunoglobulins, anti‐nuclear antibodies (ANA), antismooth muscle antibodies (ASMA), anti‐mitochondrial antibodies (AMA), anti‐liver‐kidney antibodies (LKM), anti‐parietal‐cell gastric antibodies (APCA), anti‐epithelial antibodies and concomitant autoimmune disease were studied in 27 OLP‐HCV+ve subjects and in a comparable group of 23 who were OLP‐HCV‐ve. In addition, all the patients with chronic liver disease who were seropositive for ANA, AMA or LKM were scored using the new aggregate scoring system to detect those with the accepted criteria for the diagnosis of autoimmune hepatitis (AIH). Hypergammaglobulinemia was more frequent in OLP‐HCV+ve than in OLP‐HCV‐ve (P=0.008) subjects. Serum IgG and IgM levels were higher in HCV+ve than in HCV‐ve (respectively, P=0.017 and P=0.018) individuals. However, there was no difference in the frequency of any autoantibody between OLP‐HCV+ve and OLP‐HCV‐ve patients. Overall, immunologically‐related abnormalities were found in 17(63%) OLP‐HCV+ve and 11(48%) OLP‐HCV‐ve (P=0.43) patients. Three OLP‐HCV‐ve and no OLP‐HCV+ve patients had score criteria of probable AIH. The present and our previous data suggest that OLP patients with HCV infection neither had evidence of autoimmune liver damage nor had abnormal humoral immune‐responses, with the exception of higher than control levels of serum immunoglobulins. Cryoglobulins may be responsible.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9890452</pmid><doi>10.1111/j.1600-0714.1999.tb01988.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0904-2512 |
| ispartof | Journal of oral pathology & medicine, 1999-01, Vol.28 (1), p.16-19 |
| issn | 0904-2512 1600-0714 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Aged, 80 and over Antibodies, Antinuclear - blood Autoantibodies - blood autoimmunity Autoimmunity - immunology Biological and medical sciences Blood Proteins - analysis Cryoglobulins - immunology Dentistry Epithelial Cells - immunology Female Hepatitis C - immunology hepatitis C virus Humans Hypergammaglobulinemia - blood Hypergammaglobulinemia - immunology Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin M - blood Kidney - immunology Lichen Planus, Oral - immunology Liver - immunology Liver Diseases - immunology Male Medical sciences Middle Aged Mitochondria - immunology Muscle, Smooth - immunology Non tumoral diseases oral lichen planus Otorhinolaryngology. Stomatology Parietal Cells, Gastric - immunology Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Oral lichen planus in patients infected or noninfected with hepatitis C virus: the role of autoimmunity |
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