Presence of epidermal allantoin further supports oxidative stress in vitiligo

: Xanthine dehydrogenase/xanthine oxidase (XDH/XO) catalyses the hydroxylation of hypoxanthine to xanthine and finally to uric acid in purine degradation. These reactions generate H2O2 yielding allantoin from uric acid when reactive oxygen species accumulates. The presence of XO in the human epider...

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Veröffentlicht in:	Experimental dermatology 2008-09, Vol.17 (9), p.761-770
Hauptverfasser:	Shalbaf, Mohammad, Gibbons, Nicholas C. J., Wood, John M., Maitland, Derek J., Rokos, Hartmut, Elwary, Souna M, Marles, Lee K., Schallreuter, Karin U.
Format:	Artikel
Sprache:	eng
Schlagworte:	allantoin Allantoin - biosynthesis Biological and medical sciences Blotting, Western Case-Control Studies Catalytic Domain Cells, Cultured Computer Simulation Dermatology Epidermis - metabolism Flavin-Adenine Dinucleotide - analogs & derivatives Flavin-Adenine Dinucleotide - metabolism human epidermis Humans hydrogen peroxide Hydrogen Peroxide - metabolism Immunohistochemistry Keratinocytes - enzymology Medical sciences Melanocytes - enzymology Models, Chemical Molecular Structure Oxidation-Reduction Oxidative Stress Pigmentary diseases of the skin RNA, Messenger - metabolism Uric Acid - metabolism vitiligo Vitiligo - metabolism Xanthine Dehydrogenase - metabolism xanthine oxidase Xanthine Oxidase - metabolism
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