Memory CD8 T Cell Responses Exceeding a Large but Definable Threshold Provide Long-Term Immunity to Malaria

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines. Unfortunately, repeated success of such vaccines in mice has not translated readily to effective malaria vaccines...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (37), p.14017-14022
Hauptverfasser:	Schmidt, Nathan W., Podyminogin, Rebecca L., Butler, Noah S., Badovinac, Vladimir P., Tucker, Brad J., Bahjat, Keith S., Lauer, Peter, Reyes-Sandoval, Arturo, Hutchings, Claire L., Moore, Anne C., Gilbert, Sarah C., Hill, Adrian V., Bartholomay, Lyric C., Harty, John T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences CD8-Positive T-Lymphocytes - immunology Dendritic Cells - immunology Immunity Immunity (Disease) Immunization Immunologic Memory - immunology Infections Liver Malaria Malaria - immunology Malaria - parasitology Memory Mice Mice, Inbred BALB C Plasmodium berghei Plasmodium berghei - immunology Plasmodium berghei - pathogenicity Plasmodium yoelii Protozoan Proteins - immunology Rodents Spleen Sporozoites Substrate Specificity T cell receptors T lymphocytes Time Factors Vaccination Vaccines
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