An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo
Background: Several modalities of treatment have been tried in vitiligo with varied results; however, Indian data on comparative studies of two or more therapies are limited. Aims: We compared different phototherapy methods with an oral steroid as an adjunct to determine the method with the best tol...
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| Veröffentlicht in: | Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2008-07, Vol.74 (4), p.357-360 |
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| container_title | Indian journal of dermatology, venereology, and leprology |
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| creator | Rath, Namita Kar, HK Sabhnani, Sunil |
| description | Background: Several modalities of treatment have been tried in vitiligo
with varied results; however, Indian data on comparative studies of two
or more therapies are limited. Aims: We compared different
phototherapy methods with an oral steroid as an adjunct to determine
the method with the best tolerability and efficacy. Methods:
Eighty-six patients with progressive vitiligo were randomly assigned to
different study groups according to a continuous selection method over
a period of one year. Group 1 was given OMP + PUVA, group 2 OMP + UVB
(NB), group 3 OMP + UVB (BB) and group 4 was given OMP alone. Each
patient was followed up for six months and then released from
treatment. Clinical evaluation was made at the end of three and six
months. Results: In group 1 (OMP + PUVA), marked improvement was seen
in 18.51% while moderate improvement was seen in 66.66% of the
patients. Marked improvement was seen in 37.03% in group 2 (OMP +
NB-UVB) while 44.44% had moderate improvement. In group 3 (OMP + BB
UVB), 8.33% showed marked improvement while moderate improvement was
seen in 25% of the patients. Marked and moderate improvement was seen
in 5 and 10% of group 4 (OMP) patients, respectively. Conclusions: Our
study compared four treatment modalities in vitiligo patients, out of
which oral minipulse of steroids (OMP) only had an adjunct value and
was not very effective by itself. Narrow band UVB has a definite edge
over broad band UVB and should be preferred when both options are
available. NB-UVB and PUVA showed comparable efficacy. |
| doi_str_mv | 10.4103/0378-6323.42905 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_69555745</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A185238316</galeid><sourcerecordid>A185238316</sourcerecordid><originalsourceid>FETCH-LOGICAL-b540t-f03167b6b9fcdd30b768aac6d5b06e3d16f513cfb192ef59aa107a578ada8dea3</originalsourceid><addsrcrecordid>eNptkltrFDEYhgdRbK1eeydBsCh0dpPJZA6Xa_EElfbC9nb4JofdlGwyTTJb9uf5z8x0t61KSSDhzfOdwptlbwmelQTTOaZ1k1e0oLOyaDF7lh3itqY5bYviebrfvx5kr0K4xrgoK0peZgekqdsas_ow-72wyA3SIgO9NFKcIO7WA3iIeiMRN9pqDgaFOIotchZJpZLAtwisQNEZ6aHXRsf0qJDzCV2nkGE0QU5KiNI7LdDH858XnxAYZ-UJSnd0q-MKXVxeLe4S9d6BQHNkwXt3i_pJu7z6jIaViy6uUpFhi7RFg3dLL0OYetvomAov3evshYJU7s3-PMouv375dfo9Pzv_9uN0cZb3rMQxV5iSqu6rvlVcCIr7umoAeCVYjytJBakUI5SrnrSFVKwFILgGVjcgoBES6FF2vMubmrgZZYjdWgcujQEr3Ri6qmWM1SVL4Pv_wGs3ept660jLcF2RukhQvoOWYGSnrXLRA19Km2adfknpJC9IwwrapMYTP3uCT0vIteZPBhz_FbCSYOIqODNG7Wz4F5zvQO5dCF6qbvB6DX7bEdxNJusmG3WTjbo7k6WId_sBx34txSO_d1UCPuwBCMk9yoPlOjxwBU5fVbb0caheu-Q0-UBwr6G7F8UmbdwQVtE_7pzq8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195076172</pqid></control><display><type>article</type><title>An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo</title><source>MEDLINE</source><source>Bioline International</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Rath, Namita ; Kar, HK ; Sabhnani, Sunil</creator><creatorcontrib>Rath, Namita ; Kar, HK ; Sabhnani, Sunil</creatorcontrib><description>Background: Several modalities of treatment have been tried in vitiligo
with varied results; however, Indian data on comparative studies of two
or more therapies are limited. Aims: We compared different
phototherapy methods with an oral steroid as an adjunct to determine
the method with the best tolerability and efficacy. Methods:
Eighty-six patients with progressive vitiligo were randomly assigned to
different study groups according to a continuous selection method over
a period of one year. Group 1 was given OMP + PUVA, group 2 OMP + UVB
(NB), group 3 OMP + UVB (BB) and group 4 was given OMP alone. Each
patient was followed up for six months and then released from
treatment. Clinical evaluation was made at the end of three and six
months. Results: In group 1 (OMP + PUVA), marked improvement was seen
in 18.51% while moderate improvement was seen in 66.66% of the
patients. Marked improvement was seen in 37.03% in group 2 (OMP +
NB-UVB) while 44.44% had moderate improvement. In group 3 (OMP + BB
UVB), 8.33% showed marked improvement while moderate improvement was
seen in 25% of the patients. Marked and moderate improvement was seen
in 5 and 10% of group 4 (OMP) patients, respectively. Conclusions: Our
study compared four treatment modalities in vitiligo patients, out of
which oral minipulse of steroids (OMP) only had an adjunct value and
was not very effective by itself. Narrow band UVB has a definite edge
over broad band UVB and should be preferred when both options are
available. NB-UVB and PUVA showed comparable efficacy.</description><identifier>ISSN: 0378-6323</identifier><identifier>EISSN: 0973-3922</identifier><identifier>EISSN: 1998-3611</identifier><identifier>DOI: 10.4103/0378-6323.42905</identifier><identifier>PMID: 18797057</identifier><identifier>CODEN: IJDLDY</identifier><language>eng</language><publisher>New Delhi: Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)</publisher><subject>Administration, Oral ; Adolescent ; Adult ; Biological and medical sciences ; Care and treatment ; Child ; Combined Modality Therapy ; Comparative studies ; Dermatology ; Diagnosis ; Disease Progression ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Health aspects ; Humans ; Industrial research ; Light therapy ; Medical sciences ; Medical treatment ; Middle Aged ; Oral Minipulse, PUVA, Narrow Band (UVB), Broad Band UVB, Vitiligo ; Patient outcomes ; Patients ; Phototherapy ; Pigmentary diseases of the skin ; PUVA Therapy ; Side effects ; Steroids ; Steroids - administration & dosage ; Treatment Outcome ; Ultraviolet Therapy ; Vitiligo ; Vitiligo - pathology ; Vitiligo - therapy ; Young Adult</subject><ispartof>Indian journal of dermatology, venereology, and leprology, 2008-07, Vol.74 (4), p.357-360</ispartof><rights>Copyright 2008 Indian Journal of Dermatology, Venereology and Leprology.</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2008 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications Jul/Aug 2008</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b540t-f03167b6b9fcdd30b768aac6d5b06e3d16f513cfb192ef59aa107a578ada8dea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904,79172</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20955493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18797057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rath, Namita</creatorcontrib><creatorcontrib>Kar, HK</creatorcontrib><creatorcontrib>Sabhnani, Sunil</creatorcontrib><title>An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo</title><title>Indian journal of dermatology, venereology, and leprology</title><addtitle>Indian J Dermatol Venereol Leprol</addtitle><description>Background: Several modalities of treatment have been tried in vitiligo
with varied results; however, Indian data on comparative studies of two
or more therapies are limited. Aims: We compared different
phototherapy methods with an oral steroid as an adjunct to determine
the method with the best tolerability and efficacy. Methods:
Eighty-six patients with progressive vitiligo were randomly assigned to
different study groups according to a continuous selection method over
a period of one year. Group 1 was given OMP + PUVA, group 2 OMP + UVB
(NB), group 3 OMP + UVB (BB) and group 4 was given OMP alone. Each
patient was followed up for six months and then released from
treatment. Clinical evaluation was made at the end of three and six
months. Results: In group 1 (OMP + PUVA), marked improvement was seen
in 18.51% while moderate improvement was seen in 66.66% of the
patients. Marked improvement was seen in 37.03% in group 2 (OMP +
NB-UVB) while 44.44% had moderate improvement. In group 3 (OMP + BB
UVB), 8.33% showed marked improvement while moderate improvement was
seen in 25% of the patients. Marked and moderate improvement was seen
in 5 and 10% of group 4 (OMP) patients, respectively. Conclusions: Our
study compared four treatment modalities in vitiligo patients, out of
which oral minipulse of steroids (OMP) only had an adjunct value and
was not very effective by itself. Narrow band UVB has a definite edge
over broad band UVB and should be preferred when both options are
available. NB-UVB and PUVA showed comparable efficacy.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Combined Modality Therapy</subject><subject>Comparative studies</subject><subject>Dermatology</subject><subject>Diagnosis</subject><subject>Disease Progression</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Industrial research</subject><subject>Light therapy</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Oral Minipulse, PUVA, Narrow Band (UVB), Broad Band UVB, Vitiligo</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Phototherapy</subject><subject>Pigmentary diseases of the skin</subject><subject>PUVA Therapy</subject><subject>Side effects</subject><subject>Steroids</subject><subject>Steroids - administration & dosage</subject><subject>Treatment Outcome</subject><subject>Ultraviolet Therapy</subject><subject>Vitiligo</subject><subject>Vitiligo - pathology</subject><subject>Vitiligo - therapy</subject><subject>Young Adult</subject><issn>0378-6323</issn><issn>0973-3922</issn><issn>1998-3611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkltrFDEYhgdRbK1eeydBsCh0dpPJZA6Xa_EElfbC9nb4JofdlGwyTTJb9uf5z8x0t61KSSDhzfOdwptlbwmelQTTOaZ1k1e0oLOyaDF7lh3itqY5bYviebrfvx5kr0K4xrgoK0peZgekqdsas_ow-72wyA3SIgO9NFKcIO7WA3iIeiMRN9pqDgaFOIotchZJpZLAtwisQNEZ6aHXRsf0qJDzCV2nkGE0QU5KiNI7LdDH858XnxAYZ-UJSnd0q-MKXVxeLe4S9d6BQHNkwXt3i_pJu7z6jIaViy6uUpFhi7RFg3dLL0OYetvomAov3evshYJU7s3-PMouv375dfo9Pzv_9uN0cZb3rMQxV5iSqu6rvlVcCIr7umoAeCVYjytJBakUI5SrnrSFVKwFILgGVjcgoBES6FF2vMubmrgZZYjdWgcujQEr3Ri6qmWM1SVL4Pv_wGs3ept660jLcF2RukhQvoOWYGSnrXLRA19Km2adfknpJC9IwwrapMYTP3uCT0vIteZPBhz_FbCSYOIqODNG7Wz4F5zvQO5dCF6qbvB6DX7bEdxNJusmG3WTjbo7k6WId_sBx34txSO_d1UCPuwBCMk9yoPlOjxwBU5fVbb0caheu-Q0-UBwr6G7F8UmbdwQVtE_7pzq8A</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Rath, Namita</creator><creator>Kar, HK</creator><creator>Sabhnani, Sunil</creator><general>Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)</general><general>Indian Association of Dermatologists, Venereologists and Leprologists</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Scientific Scholar</general><scope>RBI</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo</title><author>Rath, Namita ; Kar, HK ; Sabhnani, Sunil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b540t-f03167b6b9fcdd30b768aac6d5b06e3d16f513cfb192ef59aa107a578ada8dea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Combined Modality Therapy</topic><topic>Comparative studies</topic><topic>Dermatology</topic><topic>Diagnosis</topic><topic>Disease Progression</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Industrial research</topic><topic>Light therapy</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Oral Minipulse, PUVA, Narrow Band (UVB), Broad Band UVB, Vitiligo</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Phototherapy</topic><topic>Pigmentary diseases of the skin</topic><topic>PUVA Therapy</topic><topic>Side effects</topic><topic>Steroids</topic><topic>Steroids - administration & dosage</topic><topic>Treatment Outcome</topic><topic>Ultraviolet Therapy</topic><topic>Vitiligo</topic><topic>Vitiligo - pathology</topic><topic>Vitiligo - therapy</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Rath, Namita</creatorcontrib><creatorcontrib>Kar, HK</creatorcontrib><creatorcontrib>Sabhnani, Sunil</creatorcontrib><collection>Bioline International</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of dermatology, venereology, and leprology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rath, Namita</au><au>Kar, HK</au><au>Sabhnani, Sunil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo</atitle><jtitle>Indian journal of dermatology, venereology, and leprology</jtitle><addtitle>Indian J Dermatol Venereol Leprol</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>74</volume><issue>4</issue><spage>357</spage><epage>360</epage><pages>357-360</pages><issn>0378-6323</issn><eissn>0973-3922</eissn><eissn>1998-3611</eissn><coden>IJDLDY</coden><abstract>Background: Several modalities of treatment have been tried in vitiligo
with varied results; however, Indian data on comparative studies of two
or more therapies are limited. Aims: We compared different
phototherapy methods with an oral steroid as an adjunct to determine
the method with the best tolerability and efficacy. Methods:
Eighty-six patients with progressive vitiligo were randomly assigned to
different study groups according to a continuous selection method over
a period of one year. Group 1 was given OMP + PUVA, group 2 OMP + UVB
(NB), group 3 OMP + UVB (BB) and group 4 was given OMP alone. Each
patient was followed up for six months and then released from
treatment. Clinical evaluation was made at the end of three and six
months. Results: In group 1 (OMP + PUVA), marked improvement was seen
in 18.51% while moderate improvement was seen in 66.66% of the
patients. Marked improvement was seen in 37.03% in group 2 (OMP +
NB-UVB) while 44.44% had moderate improvement. In group 3 (OMP + BB
UVB), 8.33% showed marked improvement while moderate improvement was
seen in 25% of the patients. Marked and moderate improvement was seen
in 5 and 10% of group 4 (OMP) patients, respectively. Conclusions: Our
study compared four treatment modalities in vitiligo patients, out of
which oral minipulse of steroids (OMP) only had an adjunct value and
was not very effective by itself. Narrow band UVB has a definite edge
over broad band UVB and should be preferred when both options are
available. NB-UVB and PUVA showed comparable efficacy.</abstract><cop>New Delhi</cop><pub>Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)</pub><pmid>18797057</pmid><doi>10.4103/0378-6323.42905</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-6323 |
| ispartof | Indian journal of dermatology, venereology, and leprology, 2008-07, Vol.74 (4), p.357-360 |
| issn | 0378-6323 0973-3922 1998-3611 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69555745 |
| source | MEDLINE; Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Oral Adolescent Adult Biological and medical sciences Care and treatment Child Combined Modality Therapy Comparative studies Dermatology Diagnosis Disease Progression Dose-Response Relationship, Drug Drug Therapy, Combination Health aspects Humans Industrial research Light therapy Medical sciences Medical treatment Middle Aged Oral Minipulse, PUVA, Narrow Band (UVB), Broad Band UVB, Vitiligo Patient outcomes Patients Phototherapy Pigmentary diseases of the skin PUVA Therapy Side effects Steroids Steroids - administration & dosage Treatment Outcome Ultraviolet Therapy Vitiligo Vitiligo - pathology Vitiligo - therapy Young Adult |
| title | An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo |
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