Dynamics of Protein-Bound Water in the Heme Domain of P450BM3 Studied by High-Pressure Spectroscopy: Comparison with P450cam and P450 2B4

Pressure-induced transitions in the heme domain of cytochrome P450BM3 (P450BMP) were studied versus the concentration of palmitic acid. An increase in hydrostatic pressure causes a high- to low-spin shift and subsequent P450 to P420 transition. Conversion of P450BMP to P420 is associated with import...

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Veröffentlicht in:	Biochemistry (Easton) 1999-01, Vol.38 (2), p.751-761
Hauptverfasser:	Davydov, Dmitri R, Hui Bon Hoa, Gaston, Peterson, Julian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases Bacterial Proteins - chemistry Camphor 5-Monooxygenase - chemistry Cytochrome P-450 Enzyme System - chemistry Heme - chemistry Hydrostatic Pressure Microsomes, Liver - enzymology Mixed Function Oxygenases - chemistry NADPH-Ferrihemoprotein Reductase Protein Structure, Tertiary Pseudomonas putida - enzymology Rabbits Spectrophotometry - methods Steroid Hydroxylases - chemistry Substrate Specificity Thermodynamics
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