Enantioselectivity in the metabolism of mexiletine by conjugation in female patients with the arrhythmic form of chronic Chagas' heart disease

The phenomenon of enantioselectivity in the metabolism of mexiletine (MEX) conjugation was investigated in eight female patients with the arrhythmic form of chronic Chagas' heart disease treated with racemic mexiletine hydrochloride (two 100 mg capsules every 8 hr). Blood samples were collected...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1999, Vol.11 (1), p.29-32
Hauptverfasser:	Lanchote, Vera Lucia, Cesarino, Evandro José, Santos, Verônica Jorge, Mere Jr, Yussif, Santos, Silvia Regina Cavani Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - pharmacokinetics Area Under Curve Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Biotransformation Chagas Cardiomyopathy - metabolism Chagas Cardiomyopathy - physiopathology Chagas' heart disease Chronic Disease enantioselectivity Female Glucuronates - metabolism Humans Hydroxylation metabolism mexiletine Mexiletine - chemistry Mexiletine - pharmacokinetics Middle Aged N-hydroxymexiletine glucuronide patients pharmacokinetics Stereoisomerism
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