Decreased Neuroendocrine Responses to Meta-Chlorophenylpiperazine (m-CPP) but Normal Responses to Ipsapirone in Marathon Runners

Several clinical studies suggest antidepressive and anxiolytic effects of regular aerobic exercise. To study the effects of exercise on central serotonergic receptor sensitivity, we performed neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-CPP, 0.4 mg/kg), ipsapirone (0....

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 1999-02, Vol.20 (2), p.150-161
Hauptverfasser:	Broocks, Andreas, Meyer, Tim, George, Annette, Hillmer-Vogel, Ursula, Meyer, Detlef, Bandelow, Borwin, Hajak, Göran, Bartmann, Uwe, Gleiter, Christoph H, Rüther, Eckart
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anxiety - psychology Behavior - drug effects Body Temperature - drug effects Double-Blind Method Exercise Exercise Test Female Hormones - blood Humans Ipsapirone Male Marathon running Meta-chlorophenylpiperazine (m-CPP) Neurosecretory Systems - drug effects Physical Endurance - physiology Piperazines - pharmacology Pyrimidines - pharmacology Receptor, Serotonin, 5-HT2C Receptors, Serotonin - drug effects Receptors, Serotonin, 5-HT1 Running - physiology Running - psychology Serotonin
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