Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report

Abstract Background Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing ri...

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Veröffentlicht in:Surgical neurology 2008-10, Vol.70 (4), p.403-407
Hauptverfasser: Yamaguchi, Shigeru, MD, Terasaka, Shunsuke, MD, Ando, Sachiko, MD, Shinohara, Toshiya, MD, Iwasaki, Yoshinobu, MD
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container_end_page 407
container_issue 4
container_start_page 403
container_title Surgical neurology
container_volume 70
creator Yamaguchi, Shigeru, MD
Terasaka, Shunsuke, MD
Ando, Sachiko, MD
Shinohara, Toshiya, MD
Iwasaki, Yoshinobu, MD
description Abstract Background Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor. Conclusion We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. The patient has experienced complete remission, and succeeding MRI revealed no evidence of local recurrence.
doi_str_mv 10.1016/j.surneu.2007.10.020
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These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor. Conclusion We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. 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These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor. Conclusion We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. 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subjects Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Clivus
Combined Modality Therapy
Cranial Fossa, Posterior - pathology
Dexamethasone - therapeutic use
Doxorubicin - therapeutic use
Female
Humans
Magnetic Resonance Imaging
Medical sciences
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - pathology
Multiple Myeloma - surgery
Neoadjuvant Therapy
Neurology
Neurosurgery
Neurosurgical Procedures
Plasmacytoma
Plasmacytoma - drug therapy
Plasmacytoma - pathology
Plasmacytoma - surgery
Salvage Therapy
Skull base
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Vincristine - therapeutic use
title Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report
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