Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report
Abstract Background Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing ri...
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Veröffentlicht in: | Surgical neurology 2008-10, Vol.70 (4), p.403-407 |
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creator | Yamaguchi, Shigeru, MD Terasaka, Shunsuke, MD Ando, Sachiko, MD Shinohara, Toshiya, MD Iwasaki, Yoshinobu, MD |
description | Abstract Background Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor. Conclusion We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. The patient has experienced complete remission, and succeeding MRI revealed no evidence of local recurrence. |
doi_str_mv | 10.1016/j.surneu.2007.10.020 |
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These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor. Conclusion We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. The patient has experienced complete remission, and succeeding MRI revealed no evidence of local recurrence.</description><identifier>ISSN: 0090-3019</identifier><identifier>EISSN: 1879-3339</identifier><identifier>DOI: 10.1016/j.surneu.2007.10.020</identifier><identifier>PMID: 18291467</identifier><identifier>CODEN: SGNRAI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Clivus ; Combined Modality Therapy ; Cranial Fossa, Posterior - pathology ; Dexamethasone - therapeutic use ; Doxorubicin - therapeutic use ; Female ; Humans ; Magnetic Resonance Imaging ; Medical sciences ; Multiple myeloma ; Multiple Myeloma - drug therapy ; Multiple Myeloma - pathology ; Multiple Myeloma - surgery ; Neoadjuvant Therapy ; Neurology ; Neurosurgery ; Neurosurgical Procedures ; Plasmacytoma ; Plasmacytoma - drug therapy ; Plasmacytoma - pathology ; Plasmacytoma - surgery ; Salvage Therapy ; Skull base ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Vincristine - therapeutic use</subject><ispartof>Surgical neurology, 2008-10, Vol.70 (4), p.403-407</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-574318e72771cc2c02fc11566131a8bee8c476aeb03d3e4dc68c6e5b2213bafc3</citedby><cites>FETCH-LOGICAL-c445t-574318e72771cc2c02fc11566131a8bee8c476aeb03d3e4dc68c6e5b2213bafc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20696892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18291467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaguchi, Shigeru, MD</creatorcontrib><creatorcontrib>Terasaka, Shunsuke, MD</creatorcontrib><creatorcontrib>Ando, Sachiko, MD</creatorcontrib><creatorcontrib>Shinohara, Toshiya, MD</creatorcontrib><creatorcontrib>Iwasaki, Yoshinobu, MD</creatorcontrib><title>Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report</title><title>Surgical neurology</title><addtitle>Surg Neurol</addtitle><description>Abstract Background Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor. Conclusion We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. The patient has experienced complete remission, and succeeding MRI revealed no evidence of local recurrence.</description><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clivus</subject><subject>Combined Modality Therapy</subject><subject>Cranial Fossa, Posterior - pathology</subject><subject>Dexamethasone - therapeutic use</subject><subject>Doxorubicin - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - drug therapy</subject><subject>Multiple Myeloma - pathology</subject><subject>Multiple Myeloma - surgery</subject><subject>Neoadjuvant Therapy</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Neurosurgical Procedures</subject><subject>Plasmacytoma</subject><subject>Plasmacytoma - drug therapy</subject><subject>Plasmacytoma - pathology</subject><subject>Plasmacytoma - surgery</subject><subject>Salvage Therapy</subject><subject>Skull base</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Vincristine - therapeutic use</subject><issn>0090-3019</issn><issn>1879-3339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2L1TAUhoMoznX0H4h0o7teT5I2bVwIMvgFgy5UcBdO01Mm136ZpFf6703pRcGNq8DLc96EJ4expxyOHLh6eTqGxY-0HAVAlaIjCLjHDryudC6l1PfZAUBDLoHrK_YohBMASF3qh-yK10LzQlUH5j7RhO1pOeMYs3hHHuc1c2OG2YzRUQp_uXiX2d6dsc_mHsOAdo3TgBmGMFmHkdqdGZY-urmnbFipT8CrVGIxUOZpnnx8zB502Ad6cjmv2bd3b7_efMhvP7__ePPmNrdFUca8rArJa6pEVXFrhQXRWc5LpbjkWDdEtS0qhdSAbCUVrVW1VVQ2QnDZYGflNXux985--rlQiGZwwVLf40jTEozSZSmV0gksdtD6KQRPnZm9G9CvhoPZFJuT2RWbTfGWJsVp7Nmlf2kGav8OXZwm4PkFwGCx7zyO1oU_nAClVa1F4l7vHCUbZ0feBJuMW2qdJxtNO7n_veTfgvRNo0t3_qCVwmlKI8m04SYIA-bLtg7bNkAFXJT1d_kbxCuyug</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Yamaguchi, Shigeru, MD</creator><creator>Terasaka, Shunsuke, MD</creator><creator>Ando, Sachiko, MD</creator><creator>Shinohara, Toshiya, MD</creator><creator>Iwasaki, Yoshinobu, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report</title><author>Yamaguchi, Shigeru, MD ; Terasaka, Shunsuke, MD ; Ando, Sachiko, MD ; Shinohara, Toshiya, MD ; Iwasaki, Yoshinobu, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-574318e72771cc2c02fc11566131a8bee8c476aeb03d3e4dc68c6e5b2213bafc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clivus</topic><topic>Combined Modality Therapy</topic><topic>Cranial Fossa, Posterior - pathology</topic><topic>Dexamethasone - therapeutic use</topic><topic>Doxorubicin - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - drug therapy</topic><topic>Multiple Myeloma - pathology</topic><topic>Multiple Myeloma - surgery</topic><topic>Neoadjuvant Therapy</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Neurosurgical Procedures</topic><topic>Plasmacytoma</topic><topic>Plasmacytoma - drug therapy</topic><topic>Plasmacytoma - pathology</topic><topic>Plasmacytoma - surgery</topic><topic>Salvage Therapy</topic><topic>Skull base</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Vincristine - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>Yamaguchi, Shigeru, MD</creatorcontrib><creatorcontrib>Terasaka, Shunsuke, MD</creatorcontrib><creatorcontrib>Ando, Sachiko, MD</creatorcontrib><creatorcontrib>Shinohara, Toshiya, MD</creatorcontrib><creatorcontrib>Iwasaki, Yoshinobu, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaguchi, Shigeru, MD</au><au>Terasaka, Shunsuke, MD</au><au>Ando, Sachiko, MD</au><au>Shinohara, Toshiya, MD</au><au>Iwasaki, Yoshinobu, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report</atitle><jtitle>Surgical neurology</jtitle><addtitle>Surg Neurol</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>70</volume><issue>4</issue><spage>403</spage><epage>407</epage><pages>403-407</pages><issn>0090-3019</issn><eissn>1879-3339</eissn><coden>SGNRAI</coden><abstract>Abstract Background Plasmacytoma is a localized mass of metastatic plasma cells. These lesions rarely involve the petroclival region and carry a high risk of progression to MM and poor prognosis. Case Description We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy. She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor. Conclusion We presented our treatment strategy including neoadjuvant chemoradiotherapy followed by radical resection of the lesion. The patient has experienced complete remission, and succeeding MRI revealed no evidence of local recurrence.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18291467</pmid><doi>10.1016/j.surneu.2007.10.020</doi><tpages>5</tpages></addata></record> |
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subjects | Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Clivus Combined Modality Therapy Cranial Fossa, Posterior - pathology Dexamethasone - therapeutic use Doxorubicin - therapeutic use Female Humans Magnetic Resonance Imaging Medical sciences Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - pathology Multiple Myeloma - surgery Neoadjuvant Therapy Neurology Neurosurgery Neurosurgical Procedures Plasmacytoma Plasmacytoma - drug therapy Plasmacytoma - pathology Plasmacytoma - surgery Salvage Therapy Skull base Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vincristine - therapeutic use |
title | Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report |
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