A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alphavbeta3 and alphaIIbbeta3

The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease episodes. Sequence analysis of the speB gene from 200 group A Streptococcus isolates collected worldwi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-01, Vol.96 (1), p.242-247
Hauptverfasser:	Stockbauer, K E, Magoun, L, Liu, M, Burns, Jr, E H, Gubba, S, Renish, S, Pan, X, Bodary, S C, Baker, E, Coburn, J, Leong, J M, Musser, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Bacteria Bacterial Proteins Cell Adhesion - drug effects CHO Cells Cricetinae Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Endothelium, Vascular - cytology Enzymes Genetic Variation Humans Infections Integrins - genetics Integrins - metabolism Microbiology Oligopeptides - genetics Oligopeptides - metabolism Peptide Fragments - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - genetics Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Protein Binding Receptors, Vitronectin - genetics Receptors, Vitronectin - metabolism Recombinant Proteins Streptococcus pyogenes - enzymology Streptococcus pyogenes - pathogenicity
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