Measurement of Resting Cytosolic Ca2+ Concentrations and Ca2+ Store Size in HEK-293 Cells Transfected with Malignant Hyperthermia or Central Core Disease Mutant Ca2+ Release Channels

Malignant hyperthermia (MH) and central core disease (CCD) mutations were introduced into full-length rabbit Ca2+ release channel (RYR1) cDNA, which was then expressed transiently in HEK-293 cells. Resting Ca2+ concentrations were higher in HEK-293 cells expressing homotetrameric CCD mutant RyR1 tha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1999-01, Vol.274 (2), p.693-702
Hauptverfasser:	Tong, Jiefei, McCarthy, Tommie V., MacLennan, David H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caffeine - pharmacology Calcium - metabolism Calcium Channels - genetics Calcium-Transporting ATPases - metabolism Carbachol - pharmacology Cell Line Cytosol - drug effects Cytosol - metabolism Endoplasmic Reticulum - enzymology Humans Malignant Hyperthermia - metabolism Mutation Myopathies, Nemaline - metabolism Rabbits Ryanodine Receptor Calcium Release Channel - genetics Sarcoplasmic Reticulum - enzymology Thapsigargin - pharmacology Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!