Immunopathogenesis of Folliculitis Decalvans : Clues in Early Lesions
Folliculitis decalvans (FD) is a rare variant of primary cicatricial alopecia, for which the etiopathogenesis remains unclear. Our purpose was to evaluate whether certain immunologic mechanisms might have a significant role in the pathogenesis of FD. Lesional scalp biopsy specimens from 7 patients w...
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| Veröffentlicht in: | American journal of clinical pathology 2008-10, Vol.130 (4), p.526-534 |
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| container_title | American journal of clinical pathology |
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| creator | CHIARINI, Caterina TORCHIA, Daniele BIANCHI, Beatrice VOLPI, Walter CAPRONI, Marzia FABBRI, Paolo |
| description | Folliculitis decalvans (FD) is a rare variant of primary cicatricial alopecia, for which the etiopathogenesis remains unclear. Our purpose was to evaluate whether certain immunologic mechanisms might have a significant role in the pathogenesis of FD. Lesional scalp biopsy specimens from 7 patients with FD, 7 with lichen planopilaris, and 4 with alopecia areata were studied immunohistochemically by using monoclonal antibodies to CD1a, CD3, CD4, CD8, CD20, CD25, HLA-DR, interleukin (IL)-1beta, IL-4, IL-8, interferon gamma, tumor necrosis factor alpha, basic fibroblast growth factor (b-FGF), transforming growth factor (TGF)-beta, endothelial leukocyte adhesion molecule 1, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule. We showed that early FD lesions are characterized by an infiltration of activated T-helper cells, featuring mixed TH1/TH2 polarization. IL-8 and ICAM-1 may contribute to the infiltration of neutrophils, whereas b-FGF and TGF-beta may represent important mediators of the fibrosis that characterizes late-phase FD. |
| doi_str_mv | 10.1309/NG60Y7V0WNUFH4LA |
| format | Article |
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Our purpose was to evaluate whether certain immunologic mechanisms might have a significant role in the pathogenesis of FD. Lesional scalp biopsy specimens from 7 patients with FD, 7 with lichen planopilaris, and 4 with alopecia areata were studied immunohistochemically by using monoclonal antibodies to CD1a, CD3, CD4, CD8, CD20, CD25, HLA-DR, interleukin (IL)-1beta, IL-4, IL-8, interferon gamma, tumor necrosis factor alpha, basic fibroblast growth factor (b-FGF), transforming growth factor (TGF)-beta, endothelial leukocyte adhesion molecule 1, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule. We showed that early FD lesions are characterized by an infiltration of activated T-helper cells, featuring mixed TH1/TH2 polarization. IL-8 and ICAM-1 may contribute to the infiltration of neutrophils, whereas b-FGF and TGF-beta may represent important mediators of the fibrosis that characterizes late-phase FD.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/NG60Y7V0WNUFH4LA</identifier><identifier>PMID: 18794044</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adult ; Aged ; Alopecia - immunology ; Alopecia - metabolism ; Alopecia - pathology ; Alopecia Areata - immunology ; Alopecia Areata - metabolism ; Alopecia Areata - pathology ; Biological and medical sciences ; Dermatology ; Female ; Fibroblast Growth Factor 2 - metabolism ; Hair and nails disorders ; Humans ; Immunohistochemistry ; Intercellular Adhesion Molecule-1 - metabolism ; Interleukin-8 - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Lichen Planus - immunology ; Lichen Planus - metabolism ; Lichen Planus - pathology ; Male ; Medical sciences ; Middle Aged ; Pathology. 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Miscellaneous investigative techniques ; T-Lymphocytes - immunology ; Transforming Growth Factor beta - metabolism</subject><ispartof>American journal of clinical pathology, 2008-10, Vol.130 (4), p.526-534</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20660484$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18794044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHIARINI, Caterina</creatorcontrib><creatorcontrib>TORCHIA, Daniele</creatorcontrib><creatorcontrib>BIANCHI, Beatrice</creatorcontrib><creatorcontrib>VOLPI, Walter</creatorcontrib><creatorcontrib>CAPRONI, Marzia</creatorcontrib><creatorcontrib>FABBRI, Paolo</creatorcontrib><title>Immunopathogenesis of Folliculitis Decalvans : Clues in Early Lesions</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Folliculitis decalvans (FD) is a rare variant of primary cicatricial alopecia, for which the etiopathogenesis remains unclear. Our purpose was to evaluate whether certain immunologic mechanisms might have a significant role in the pathogenesis of FD. Lesional scalp biopsy specimens from 7 patients with FD, 7 with lichen planopilaris, and 4 with alopecia areata were studied immunohistochemically by using monoclonal antibodies to CD1a, CD3, CD4, CD8, CD20, CD25, HLA-DR, interleukin (IL)-1beta, IL-4, IL-8, interferon gamma, tumor necrosis factor alpha, basic fibroblast growth factor (b-FGF), transforming growth factor (TGF)-beta, endothelial leukocyte adhesion molecule 1, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule. We showed that early FD lesions are characterized by an infiltration of activated T-helper cells, featuring mixed TH1/TH2 polarization. IL-8 and ICAM-1 may contribute to the infiltration of neutrophils, whereas b-FGF and TGF-beta may represent important mediators of the fibrosis that characterizes late-phase FD.</description><subject>Adult</subject><subject>Aged</subject><subject>Alopecia - immunology</subject><subject>Alopecia - metabolism</subject><subject>Alopecia - pathology</subject><subject>Alopecia Areata - immunology</subject><subject>Alopecia Areata - metabolism</subject><subject>Alopecia Areata - pathology</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Hair and nails disorders</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Interleukin-8 - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lichen Planus - immunology</subject><subject>Lichen Planus - metabolism</subject><subject>Lichen Planus - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>T-Lymphocytes - immunology</subject><subject>Transforming Growth Factor beta - metabolism</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAURoMozji6dyXd6K6aV5PG3TDOQyjjxlFclSRNtZI2Y9MK8--NTFFw4-py4XzfvRwAzhG8RgSKm_WSwRf-BJ_Xm8WKZtMDMEaCkphzjA_BGEKIY4E4GYET798hRDiF9BiMUMoFhZSOwfy-rvvGbWX35l5NY3zlI1dGC2dtpXtbdWG_M1raT9n46Daa2d74qGqiuWztLspCwDX-FByV0npzNswJ2Czmj7NVnD0s72fTLNYYsy5WCicKp0JzRBTRTBfcEFyIVLNSUikSVZQF5qUwQhvOuDJIKJVKiU1CtCFkAq72vdvWfYRHuryuvDbWysa43udMJAnm9H8QQwYFI0kA4R7UrfO-NWW-batatrscwfzbcf7XcYhcDN29qk3xGxikBuByAKQP5spWNrryP1y4zSBNKfkC-JuF4g</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>CHIARINI, Caterina</creator><creator>TORCHIA, Daniele</creator><creator>BIANCHI, Beatrice</creator><creator>VOLPI, Walter</creator><creator>CAPRONI, Marzia</creator><creator>FABBRI, Paolo</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>Immunopathogenesis of Folliculitis Decalvans : Clues in Early Lesions</title><author>CHIARINI, Caterina ; TORCHIA, Daniele ; BIANCHI, Beatrice ; VOLPI, Walter ; CAPRONI, Marzia ; FABBRI, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-bb25b289c713b3c6cd7e32d98c6fa4a95bdfd27f9e9ce767be19bb8aa2e53ce33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alopecia - immunology</topic><topic>Alopecia - metabolism</topic><topic>Alopecia - pathology</topic><topic>Alopecia Areata - immunology</topic><topic>Alopecia Areata - metabolism</topic><topic>Alopecia Areata - pathology</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Hair and nails disorders</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Interleukin-8 - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lichen Planus - immunology</topic><topic>Lichen Planus - metabolism</topic><topic>Lichen Planus - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>T-Lymphocytes - immunology</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHIARINI, Caterina</creatorcontrib><creatorcontrib>TORCHIA, Daniele</creatorcontrib><creatorcontrib>BIANCHI, Beatrice</creatorcontrib><creatorcontrib>VOLPI, Walter</creatorcontrib><creatorcontrib>CAPRONI, Marzia</creatorcontrib><creatorcontrib>FABBRI, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHIARINI, Caterina</au><au>TORCHIA, Daniele</au><au>BIANCHI, Beatrice</au><au>VOLPI, Walter</au><au>CAPRONI, Marzia</au><au>FABBRI, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunopathogenesis of Folliculitis Decalvans : Clues in Early Lesions</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2008-10</date><risdate>2008</risdate><volume>130</volume><issue>4</issue><spage>526</spage><epage>534</epage><pages>526-534</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Folliculitis decalvans (FD) is a rare variant of primary cicatricial alopecia, for which the etiopathogenesis remains unclear. Our purpose was to evaluate whether certain immunologic mechanisms might have a significant role in the pathogenesis of FD. Lesional scalp biopsy specimens from 7 patients with FD, 7 with lichen planopilaris, and 4 with alopecia areata were studied immunohistochemically by using monoclonal antibodies to CD1a, CD3, CD4, CD8, CD20, CD25, HLA-DR, interleukin (IL)-1beta, IL-4, IL-8, interferon gamma, tumor necrosis factor alpha, basic fibroblast growth factor (b-FGF), transforming growth factor (TGF)-beta, endothelial leukocyte adhesion molecule 1, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule. We showed that early FD lesions are characterized by an infiltration of activated T-helper cells, featuring mixed TH1/TH2 polarization. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged Alopecia - immunology Alopecia - metabolism Alopecia - pathology Alopecia Areata - immunology Alopecia Areata - metabolism Alopecia Areata - pathology Biological and medical sciences Dermatology Female Fibroblast Growth Factor 2 - metabolism Hair and nails disorders Humans Immunohistochemistry Intercellular Adhesion Molecule-1 - metabolism Interleukin-8 - metabolism Investigative techniques, diagnostic techniques (general aspects) Lichen Planus - immunology Lichen Planus - metabolism Lichen Planus - pathology Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques T-Lymphocytes - immunology Transforming Growth Factor beta - metabolism |
| title | Immunopathogenesis of Folliculitis Decalvans : Clues in Early Lesions |
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