A nutrient-regulated cytosolic calcium oscillator in endocrine pancreatic glucagon-secreting cells

We investigated the influence of nutrients on spontaneous cytosolic calcium oscillations in InR1-G9 glucagonoma cells, a model for pancreatic alpha-cells. The oscillations depended on calcium release from stores and on calcium influx, partly through voltage-dependent calcium channels. Oscillations r...

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Veröffentlicht in:	Pflügers Archiv 1999-02, Vol.437 (3), p.324-334
Hauptverfasser:	Bode, H P, Weber, S, Fehmann, H C, Göke, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine - pharmacology Animals Calcium Calcium - metabolism Carbachol - pharmacology Cells Cricetinae Cytosol - metabolism Energy Metabolism Glucagon - secretion Glucagonoma - physiopathology Glucose - pharmacology Glutamine - pharmacology Homeostasis Islets of Langerhans - metabolism Membrane Potentials - physiology Muscarinic Agonists - pharmacology Pancreatic Neoplasms - physiopathology Periodicity Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism Tumor Cells, Cultured
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