Carrier-Mediated Absorption of Salicylic Acid from Hamster Cheek Pouch Mucosa
Previously, we found that monocarboxylic acids undergo carrier‐mediated transport in primary cultures of oral mucosal epithelial cells.1 In this study, we investigated whether carrier‐mediated absorption of a monocarboxylic acid from the oral mucosa occurs in vivo. Salicylic acid was administered to...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1999-01, Vol.88 (1), p.142-146 |
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| creator | Utoguchi, Naoki Watanabe, Yoshiteru Takase, Yuka Suzuki, Takahisa Matsumoto, Mitsuo |
| description | Previously, we found that monocarboxylic acids undergo carrier‐mediated transport in primary cultures of oral mucosal epithelial cells.1 In this study, we investigated whether carrier‐mediated absorption of a monocarboxylic acid from the oral mucosa occurs in vivo. Salicylic acid was administered to hamster cheek pouch. At predetermined intervals, the concentration of salicylic acid in the fluid remaining in the cheek pouch lumen and the blood salicylic acid concentration were determined. The absorption of salicylic acid was saturable at high salicylic acid concentrations. Sodium azide, a metabolic inhibitor, and carbonylcyanide p‐trifluoromethoxyphenylhy‐drazone (FCCP), a protonophore, significantly inhibited the absorption of salicylic acid but not the absorption of salicylamide from the oral mucosa. Various monocarboxylic acids inhibited the absorption of salicylic acid, whereas dicarboxylic acids had no such effect. Transfer of [14C]salicylic acid from the cheek pouch mucosa to the systemic circulation was observed, and the blood [14C]salicylic acid concentration in the case of coadministration with propionic acid was significantly lower than that in the case of no propionic acid coadministration. These results show that monocarboxylic acids undergo carrier‐mediated absorption from the hamster cheek pouch mucosa. |
| doi_str_mv | 10.1021/js970412e |
| format | Article |
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Salicylic acid was administered to hamster cheek pouch. At predetermined intervals, the concentration of salicylic acid in the fluid remaining in the cheek pouch lumen and the blood salicylic acid concentration were determined. The absorption of salicylic acid was saturable at high salicylic acid concentrations. Sodium azide, a metabolic inhibitor, and carbonylcyanide p‐trifluoromethoxyphenylhy‐drazone (FCCP), a protonophore, significantly inhibited the absorption of salicylic acid but not the absorption of salicylamide from the oral mucosa. Various monocarboxylic acids inhibited the absorption of salicylic acid, whereas dicarboxylic acids had no such effect. Transfer of [14C]salicylic acid from the cheek pouch mucosa to the systemic circulation was observed, and the blood [14C]salicylic acid concentration in the case of coadministration with propionic acid was significantly lower than that in the case of no propionic acid coadministration. These results show that monocarboxylic acids undergo carrier‐mediated absorption from the hamster cheek pouch mucosa.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1021/js970412e</identifier><identifier>PMID: 9874716</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Absorption ; Animals ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Carboxylic Acids - chemistry ; Cells, Cultured ; Cheek ; Cricetinae ; Drug Carriers ; Epithelial Cells - metabolism ; Hydrogen-Ion Concentration ; Medical sciences ; Mesocricetus ; Mouth Mucosa - metabolism ; Pharmacology. Drug treatments ; Salicylic Acid - pharmacokinetics ; Temperature</subject><ispartof>Journal of pharmaceutical sciences, 1999-01, Vol.88 (1), p.142-146</ispartof><rights>1999 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1999 Wiley‐Liss, Inc. and the American Pharmaceutical Association</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4942-59cd6cb6a216e1483daddf5ac223a1038712240589499ce56d92b1dbab6333c13</citedby><cites>FETCH-LOGICAL-c4942-59cd6cb6a216e1483daddf5ac223a1038712240589499ce56d92b1dbab6333c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1021%2Fjs970412e$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1021%2Fjs970412e$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1647032$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9874716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Utoguchi, Naoki</creatorcontrib><creatorcontrib>Watanabe, Yoshiteru</creatorcontrib><creatorcontrib>Takase, Yuka</creatorcontrib><creatorcontrib>Suzuki, Takahisa</creatorcontrib><creatorcontrib>Matsumoto, Mitsuo</creatorcontrib><title>Carrier-Mediated Absorption of Salicylic Acid from Hamster Cheek Pouch Mucosa</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Previously, we found that monocarboxylic acids undergo carrier‐mediated transport in primary cultures of oral mucosal epithelial cells.1 In this study, we investigated whether carrier‐mediated absorption of a monocarboxylic acid from the oral mucosa occurs in vivo. Salicylic acid was administered to hamster cheek pouch. At predetermined intervals, the concentration of salicylic acid in the fluid remaining in the cheek pouch lumen and the blood salicylic acid concentration were determined. The absorption of salicylic acid was saturable at high salicylic acid concentrations. Sodium azide, a metabolic inhibitor, and carbonylcyanide p‐trifluoromethoxyphenylhy‐drazone (FCCP), a protonophore, significantly inhibited the absorption of salicylic acid but not the absorption of salicylamide from the oral mucosa. Various monocarboxylic acids inhibited the absorption of salicylic acid, whereas dicarboxylic acids had no such effect. Transfer of [14C]salicylic acid from the cheek pouch mucosa to the systemic circulation was observed, and the blood [14C]salicylic acid concentration in the case of coadministration with propionic acid was significantly lower than that in the case of no propionic acid coadministration. These results show that monocarboxylic acids undergo carrier‐mediated absorption from the hamster cheek pouch mucosa.</description><subject>Absorption</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Carboxylic Acids - chemistry</subject><subject>Cells, Cultured</subject><subject>Cheek</subject><subject>Cricetinae</subject><subject>Drug Carriers</subject><subject>Epithelial Cells - metabolism</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Mouth Mucosa - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Salicylic Acid - pharmacokinetics</subject><subject>Temperature</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctu1DAUBmALgcpQWPAASFmgSkgN-BLb8XKI6AV1YKQWdWk59onqNhkPdlKYt8dVRsMGFpYX59Nv-T8IvSX4I8GUfLpPSuKKUHiGFoRTXApM5HO0wJjSkvFKvUSvUrrHGAvM-RE6UrWsJBELtGpMjB5iuQLnzQiuWLYpxO3ow6YIXXFtem93-RRL613RxTAUF2ZII8SiuQN4KNZhsnfFarIhmdfoRWf6BG_29zH6cfblprkor76fXzbLq9JWqqIlV9YJ2wpDiQBS1cwZ5zpuLKXMEMxqSSitMK9VpZQFLpyiLXGtaQVjzBJ2jE7m3G0MPydIox58stD3ZgNhSloozklNVIYfZmhjSClCp7fRDybuNMH6qTp9qC7bd_vQqR3AHeS-qzx_v5-bZE3fRbOxPv0NFJXEjGZ2OrNfvofd_9_TX9fX9ImXM_e5098HbuKDFpJJrm-_nevm9vPN2VoqLbNns4fc72PenE7Ww8bm9UWwo3bB_-NvfwAZrKMD</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Utoguchi, Naoki</creator><creator>Watanabe, Yoshiteru</creator><creator>Takase, Yuka</creator><creator>Suzuki, Takahisa</creator><creator>Matsumoto, Mitsuo</creator><general>Elsevier Inc</general><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Carrier-Mediated Absorption of Salicylic Acid from Hamster Cheek Pouch Mucosa</title><author>Utoguchi, Naoki ; Watanabe, Yoshiteru ; Takase, Yuka ; Suzuki, Takahisa ; Matsumoto, Mitsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4942-59cd6cb6a216e1483daddf5ac223a1038712240589499ce56d92b1dbab6333c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Carboxylic Acids - chemistry</topic><topic>Cells, Cultured</topic><topic>Cheek</topic><topic>Cricetinae</topic><topic>Drug Carriers</topic><topic>Epithelial Cells - metabolism</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Mouth Mucosa - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Salicylic Acid - pharmacokinetics</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Utoguchi, Naoki</creatorcontrib><creatorcontrib>Watanabe, Yoshiteru</creatorcontrib><creatorcontrib>Takase, Yuka</creatorcontrib><creatorcontrib>Suzuki, Takahisa</creatorcontrib><creatorcontrib>Matsumoto, Mitsuo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Utoguchi, Naoki</au><au>Watanabe, Yoshiteru</au><au>Takase, Yuka</au><au>Suzuki, Takahisa</au><au>Matsumoto, Mitsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carrier-Mediated Absorption of Salicylic Acid from Hamster Cheek Pouch Mucosa</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1999-01</date><risdate>1999</risdate><volume>88</volume><issue>1</issue><spage>142</spage><epage>146</epage><pages>142-146</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Previously, we found that monocarboxylic acids undergo carrier‐mediated transport in primary cultures of oral mucosal epithelial cells.1 In this study, we investigated whether carrier‐mediated absorption of a monocarboxylic acid from the oral mucosa occurs in vivo. Salicylic acid was administered to hamster cheek pouch. At predetermined intervals, the concentration of salicylic acid in the fluid remaining in the cheek pouch lumen and the blood salicylic acid concentration were determined. The absorption of salicylic acid was saturable at high salicylic acid concentrations. Sodium azide, a metabolic inhibitor, and carbonylcyanide p‐trifluoromethoxyphenylhy‐drazone (FCCP), a protonophore, significantly inhibited the absorption of salicylic acid but not the absorption of salicylamide from the oral mucosa. Various monocarboxylic acids inhibited the absorption of salicylic acid, whereas dicarboxylic acids had no such effect. Transfer of [14C]salicylic acid from the cheek pouch mucosa to the systemic circulation was observed, and the blood [14C]salicylic acid concentration in the case of coadministration with propionic acid was significantly lower than that in the case of no propionic acid coadministration. These results show that monocarboxylic acids undergo carrier‐mediated absorption from the hamster cheek pouch mucosa.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>9874716</pmid><doi>10.1021/js970412e</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1999-01, Vol.88 (1), p.142-146 |
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| subjects | Absorption Animals Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Carboxylic Acids - chemistry Cells, Cultured Cheek Cricetinae Drug Carriers Epithelial Cells - metabolism Hydrogen-Ion Concentration Medical sciences Mesocricetus Mouth Mucosa - metabolism Pharmacology. Drug treatments Salicylic Acid - pharmacokinetics Temperature |
| title | Carrier-Mediated Absorption of Salicylic Acid from Hamster Cheek Pouch Mucosa |
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