Brain-IL-1beta induces local inflammation but systemic anti-inflammatory response through stimulation of both hypothalamic-pituitary-adrenal axis and sympathetic nervous system

It is well established that systemic inflammation induces a counter-regulatory anti-inflammatory response particularly resulting in deactivation of monocytes/macrophages. However, recently we demonstrated a systemic anti-inflammatory response without preceding signs of systemic inflammation in patie...

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Veröffentlicht in:	Brain research 1999-01, Vol.816 (2), p.563-571
Hauptverfasser:	Woiciechowsky, C, Schöning, B, Daberkow, N, Asche, K, Stoltenburg, G, Lanksch, W R, Volk, H D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Brain - drug effects Disease Models, Animal Hypothalamo-Hypophyseal System - drug effects Inflammation - chemically induced Infusion Pumps, Implantable Injections, Intraventricular Interleukin-1 - pharmacology Male Pituitary-Adrenal System - drug effects Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Stimulation, Chemical Sympathetic Nervous System - drug effects
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