Identification of a Conserved Universal Th Epitope in HIV-1 Reverse Transcriptase That Is Processed and Presented to HIV-Specific CD4+ T Cells by at Least Four Unrelated HLA-DR Molecules

CD4+ Th cells play an important role in the induction and maintenance of specific T cell immunity. Indications for a protective role of CD4+ T cells against HIV-1 infection were found in subjects who were able to control HIV-1 viremia as well as in highly HIV-1-exposed, yet seronegative, individuals...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-01, Vol.162 (1), p.152-160
Hauptverfasser:	van der Burg, Sjoerd H, Kwappenberg, Kitty M. C, Geluk, Annemieke, van der Kruk, Marjolein, Pontesilli, Oscar, Hovenkamp, Egbert, Franken, Kees L. M. C, van Meijgaarden, Krista E, Drijfhout, Jan-Wouter, Ottenhoff, Tom H. M, Melief, Cornelis J. M, Offringa, Rienk
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Antigen Presentation CD4-Positive T-Lymphocytes - enzymology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology Clone Cells Conserved Sequence Cytokines - biosynthesis Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism HIV Reverse Transcriptase - immunology HIV Reverse Transcriptase - metabolism HIV-1 - immunology HLA-DR Antigens - metabolism Humans Lymphocyte Activation - drug effects Molecular Sequence Data Peptides - immunology Peptides - metabolism Peptides - pharmacology Protein Binding - immunology T-Lymphocyte Subsets - enzymology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology T-Lymphocytes, Helper-Inducer - enzymology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - virology
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