Secretory Immunity in Defense against Cariogenic Mutans Streptococci
Specific immune defense against cariogenic mutans streptococci is provided largely by salivary secretory IgA antibodies, which are generated by the common mucosal immune system. This system is functional in newborn infants, who develop salivary IgA antibodies as they become colonized by oral microor...
Gespeichert in:
| Veröffentlicht in: | Caries research 1999-01, Vol.33 (1), p.4-15 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 15 |
|---|---|
| container_issue | 1 |
| container_start_page | 4 |
| container_title | Caries research |
| container_volume | 33 |
| creator | Russell, M.W. Hajishengallis, G. Childers, N.K. Michalek, S.M. |
| description | Specific immune defense against cariogenic mutans streptococci is provided largely by salivary secretory IgA antibodies, which are generated by the common mucosal immune system. This system is functional in newborn infants, who develop salivary IgA antibodies as they become colonized by oral microorganisms. The mechanisms of action of salivary IgA antibodies include interference with sucrose–independent and sucrose– dependent attachment of mutans streptococci to tooth surfaces, as well as possible inhibition of metabolic activities. The goal of protecting infants against colonization by mutans streptococci might be accomplished by applying new strategies of mucosal immunization that would induce salivary IgA antibodies without the complications of parenteral immunization. Strategies of mucosal immunization against mutans streptococci currently under development include the use of surface adhesins and glucosyltransferase as key antigens, which are being incorporated into novel mucosal vaccine delivery systems and adjuvants. The oral application of preformed, genetically engineered antibodies to mutans streptococcal antigens also offers new prospects for passive immunization against dental caries. |
| doi_str_mv | 10.1159/000016490 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_karge</sourceid><recordid>TN_cdi_proquest_miscellaneous_69548229</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69548229</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-39f83eeb0457549bfec445bcfbf6ba51f5058eaca88ef3bd44d03272eedcb7c33</originalsourceid><addsrcrecordid>eNqF0M1LwzAYBvAgypzTg2cRigfBQ7VJkzQ5yubHYOJhCt5Kmr4ZmWs7k_Sw_97ohoIXcwnk_eWB90HoFGfXGDN5k8WDOZXZHhpiSnAqC_62j4bxWaSccXGIjrxfRkQ5FwM0kCLHRcGGaDIH7SB0bpNMm6Zvbdgktk0mYKD1kKiFsq0PyVg52y2gtTp56oNqfTIPDtah053W9hgdGLXycLK7R-j1_u5l_JjOnh-m49tZqimhIc2lETlAlVFWMCorA5pSVmlTGV4phg3LmACllRBg8qqmtM5yUhCAWleFzvMRutzmrl330YMPZWO9htVKtdD1vuSSUUGI_BfiIueMSRbhxR-47HrXxiVKQjKCMS9wRFdbpF3nvQNTrp1tlNuUOCu_-i9_-o_2fBfYVw3UP3JXeJyfbefvyi3A_SZ9__4EPPKIhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220211671</pqid></control><display><type>article</type><title>Secretory Immunity in Defense against Cariogenic Mutans Streptococci</title><source>MEDLINE</source><source>Karger Journals Complete</source><creator>Russell, M.W. ; Hajishengallis, G. ; Childers, N.K. ; Michalek, S.M.</creator><creatorcontrib>Russell, M.W. ; Hajishengallis, G. ; Childers, N.K. ; Michalek, S.M.</creatorcontrib><description>Specific immune defense against cariogenic mutans streptococci is provided largely by salivary secretory IgA antibodies, which are generated by the common mucosal immune system. This system is functional in newborn infants, who develop salivary IgA antibodies as they become colonized by oral microorganisms. The mechanisms of action of salivary IgA antibodies include interference with sucrose–independent and sucrose– dependent attachment of mutans streptococci to tooth surfaces, as well as possible inhibition of metabolic activities. The goal of protecting infants against colonization by mutans streptococci might be accomplished by applying new strategies of mucosal immunization that would induce salivary IgA antibodies without the complications of parenteral immunization. Strategies of mucosal immunization against mutans streptococci currently under development include the use of surface adhesins and glucosyltransferase as key antigens, which are being incorporated into novel mucosal vaccine delivery systems and adjuvants. The oral application of preformed, genetically engineered antibodies to mutans streptococcal antigens also offers new prospects for passive immunization against dental caries.</description><identifier>ISSN: 0008-6568</identifier><identifier>EISSN: 1421-976X</identifier><identifier>DOI: 10.1159/000016490</identifier><identifier>PMID: 9831775</identifier><identifier>CODEN: CAREBK</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adhesins, Bacterial - immunology ; Adjuvants, Immunologic - chemical synthesis ; Adult ; Antibodies, Bacterial - genetics ; Antibodies, Bacterial - immunology ; Antigens, Bacterial - immunology ; Bacterial Adhesion - immunology ; Bacterial Vaccines - chemical synthesis ; Dental Caries - immunology ; Dental Caries - microbiology ; Dentistry ; glucosyltransferase ; Glycosyltransferases - immunology ; Humans ; Immunity, Mucosal ; Immunization ; Immunization, Passive ; Immunoglobulin A, Secretory - immunology ; Infant ; Infant, Newborn ; Invited Review ; Saliva - immunology ; Salivary Proteins and Peptides - immunology ; Streptococcus mutans ; Streptococcus mutans - immunology ; Streptococcus mutans - metabolism ; Streptococcus sobrinus - immunology ; Streptococcus sobrinus - metabolism ; Sucrose - metabolism</subject><ispartof>Caries research, 1999-01, Vol.33 (1), p.4-15</ispartof><rights>1998 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Jan/Feb 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-39f83eeb0457549bfec445bcfbf6ba51f5058eaca88ef3bd44d03272eedcb7c33</citedby><cites>FETCH-LOGICAL-c424t-39f83eeb0457549bfec445bcfbf6ba51f5058eaca88ef3bd44d03272eedcb7c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9831775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russell, M.W.</creatorcontrib><creatorcontrib>Hajishengallis, G.</creatorcontrib><creatorcontrib>Childers, N.K.</creatorcontrib><creatorcontrib>Michalek, S.M.</creatorcontrib><title>Secretory Immunity in Defense against Cariogenic Mutans Streptococci</title><title>Caries research</title><addtitle>Caries Res</addtitle><description>Specific immune defense against cariogenic mutans streptococci is provided largely by salivary secretory IgA antibodies, which are generated by the common mucosal immune system. This system is functional in newborn infants, who develop salivary IgA antibodies as they become colonized by oral microorganisms. The mechanisms of action of salivary IgA antibodies include interference with sucrose–independent and sucrose– dependent attachment of mutans streptococci to tooth surfaces, as well as possible inhibition of metabolic activities. The goal of protecting infants against colonization by mutans streptococci might be accomplished by applying new strategies of mucosal immunization that would induce salivary IgA antibodies without the complications of parenteral immunization. Strategies of mucosal immunization against mutans streptococci currently under development include the use of surface adhesins and glucosyltransferase as key antigens, which are being incorporated into novel mucosal vaccine delivery systems and adjuvants. The oral application of preformed, genetically engineered antibodies to mutans streptococcal antigens also offers new prospects for passive immunization against dental caries.</description><subject>Adhesins, Bacterial - immunology</subject><subject>Adjuvants, Immunologic - chemical synthesis</subject><subject>Adult</subject><subject>Antibodies, Bacterial - genetics</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial Adhesion - immunology</subject><subject>Bacterial Vaccines - chemical synthesis</subject><subject>Dental Caries - immunology</subject><subject>Dental Caries - microbiology</subject><subject>Dentistry</subject><subject>glucosyltransferase</subject><subject>Glycosyltransferases - immunology</subject><subject>Humans</subject><subject>Immunity, Mucosal</subject><subject>Immunization</subject><subject>Immunization, Passive</subject><subject>Immunoglobulin A, Secretory - immunology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Invited Review</subject><subject>Saliva - immunology</subject><subject>Salivary Proteins and Peptides - immunology</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - immunology</subject><subject>Streptococcus mutans - metabolism</subject><subject>Streptococcus sobrinus - immunology</subject><subject>Streptococcus sobrinus - metabolism</subject><subject>Sucrose - metabolism</subject><issn>0008-6568</issn><issn>1421-976X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0M1LwzAYBvAgypzTg2cRigfBQ7VJkzQ5yubHYOJhCt5Kmr4ZmWs7k_Sw_97ohoIXcwnk_eWB90HoFGfXGDN5k8WDOZXZHhpiSnAqC_62j4bxWaSccXGIjrxfRkQ5FwM0kCLHRcGGaDIH7SB0bpNMm6Zvbdgktk0mYKD1kKiFsq0PyVg52y2gtTp56oNqfTIPDtah053W9hgdGLXycLK7R-j1_u5l_JjOnh-m49tZqimhIc2lETlAlVFWMCorA5pSVmlTGV4phg3LmACllRBg8qqmtM5yUhCAWleFzvMRutzmrl330YMPZWO9htVKtdD1vuSSUUGI_BfiIueMSRbhxR-47HrXxiVKQjKCMS9wRFdbpF3nvQNTrp1tlNuUOCu_-i9_-o_2fBfYVw3UP3JXeJyfbefvyi3A_SZ9__4EPPKIhw</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Russell, M.W.</creator><creator>Hajishengallis, G.</creator><creator>Childers, N.K.</creator><creator>Michalek, S.M.</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>Secretory Immunity in Defense against Cariogenic Mutans Streptococci</title><author>Russell, M.W. ; Hajishengallis, G. ; Childers, N.K. ; Michalek, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-39f83eeb0457549bfec445bcfbf6ba51f5058eaca88ef3bd44d03272eedcb7c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adhesins, Bacterial - immunology</topic><topic>Adjuvants, Immunologic - chemical synthesis</topic><topic>Adult</topic><topic>Antibodies, Bacterial - genetics</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacterial Adhesion - immunology</topic><topic>Bacterial Vaccines - chemical synthesis</topic><topic>Dental Caries - immunology</topic><topic>Dental Caries - microbiology</topic><topic>Dentistry</topic><topic>glucosyltransferase</topic><topic>Glycosyltransferases - immunology</topic><topic>Humans</topic><topic>Immunity, Mucosal</topic><topic>Immunization</topic><topic>Immunization, Passive</topic><topic>Immunoglobulin A, Secretory - immunology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Invited Review</topic><topic>Saliva - immunology</topic><topic>Salivary Proteins and Peptides - immunology</topic><topic>Streptococcus mutans</topic><topic>Streptococcus mutans - immunology</topic><topic>Streptococcus mutans - metabolism</topic><topic>Streptococcus sobrinus - immunology</topic><topic>Streptococcus sobrinus - metabolism</topic><topic>Sucrose - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russell, M.W.</creatorcontrib><creatorcontrib>Hajishengallis, G.</creatorcontrib><creatorcontrib>Childers, N.K.</creatorcontrib><creatorcontrib>Michalek, S.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Caries research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russell, M.W.</au><au>Hajishengallis, G.</au><au>Childers, N.K.</au><au>Michalek, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secretory Immunity in Defense against Cariogenic Mutans Streptococci</atitle><jtitle>Caries research</jtitle><addtitle>Caries Res</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>33</volume><issue>1</issue><spage>4</spage><epage>15</epage><pages>4-15</pages><issn>0008-6568</issn><eissn>1421-976X</eissn><coden>CAREBK</coden><abstract>Specific immune defense against cariogenic mutans streptococci is provided largely by salivary secretory IgA antibodies, which are generated by the common mucosal immune system. This system is functional in newborn infants, who develop salivary IgA antibodies as they become colonized by oral microorganisms. The mechanisms of action of salivary IgA antibodies include interference with sucrose–independent and sucrose– dependent attachment of mutans streptococci to tooth surfaces, as well as possible inhibition of metabolic activities. The goal of protecting infants against colonization by mutans streptococci might be accomplished by applying new strategies of mucosal immunization that would induce salivary IgA antibodies without the complications of parenteral immunization. Strategies of mucosal immunization against mutans streptococci currently under development include the use of surface adhesins and glucosyltransferase as key antigens, which are being incorporated into novel mucosal vaccine delivery systems and adjuvants. The oral application of preformed, genetically engineered antibodies to mutans streptococcal antigens also offers new prospects for passive immunization against dental caries.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>9831775</pmid><doi>10.1159/000016490</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-6568 |
| ispartof | Caries research, 1999-01, Vol.33 (1), p.4-15 |
| issn | 0008-6568 1421-976X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69548229 |
| source | MEDLINE; Karger Journals Complete |
| subjects | Adhesins, Bacterial - immunology Adjuvants, Immunologic - chemical synthesis Adult Antibodies, Bacterial - genetics Antibodies, Bacterial - immunology Antigens, Bacterial - immunology Bacterial Adhesion - immunology Bacterial Vaccines - chemical synthesis Dental Caries - immunology Dental Caries - microbiology Dentistry glucosyltransferase Glycosyltransferases - immunology Humans Immunity, Mucosal Immunization Immunization, Passive Immunoglobulin A, Secretory - immunology Infant Infant, Newborn Invited Review Saliva - immunology Salivary Proteins and Peptides - immunology Streptococcus mutans Streptococcus mutans - immunology Streptococcus mutans - metabolism Streptococcus sobrinus - immunology Streptococcus sobrinus - metabolism Sucrose - metabolism |
| title | Secretory Immunity in Defense against Cariogenic Mutans Streptococci |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T21%3A23%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_karge&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Secretory%20Immunity%20in%20Defense%20against%20Cariogenic%20Mutans%20Streptococci&rft.jtitle=Caries%20research&rft.au=Russell,%20M.W.&rft.date=1999-01-01&rft.volume=33&rft.issue=1&rft.spage=4&rft.epage=15&rft.pages=4-15&rft.issn=0008-6568&rft.eissn=1421-976X&rft.coden=CAREBK&rft_id=info:doi/10.1159/000016490&rft_dat=%3Cproquest_karge%3E69548229%3C/proquest_karge%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220211671&rft_id=info:pmid/9831775&rfr_iscdi=true |